Hemophilia A is an inherited blood disorder where the blood does not clot normally due to a lack of clotting factor VIII. Symptoms include spontaneous bleeding, bruising, joint pain and swelling, and internal bleeding. The disease is passed down from mothers to sons on the X chromosome. Treatment involves replacing the missing clotting factor through intravenous injections or nasal spray medication. There is no cure for hemophilia, but genetic counseling can help determine risk for children.

1. Hemophilia A Inherited blood disease where your blood doesn’t clot normally.

9. How It Normally Works Blood vessels are cut or damaged Clotting factor recruits collagen http://www.3dchem.com/molecules.asp?ID=195 8 7 Blood reacts to clotting factors Platelets form plug at the injury site Bleeding stops!! 11 10 9 How Disease Affects Homeostasis No clotting factor to recruit collagen No clotting factor for blood to react to Platelets don’t form a plug Bleeding Does Not Stop! 12