1. WELCOME

2. GREEN CHEMISTRY IN
PHARMACEUTICALS

3. PRESENTED BY,
NIKHIL MOHAN.P.M
AYISHA
MUBEENA.A
SREELAKSHMI.K
SAREENA
NASRIN.K.P
AKHILA
ATHIRA HARIDAS

4. WHAT IS GREEN CHEMISTRY?

5. Green chemistry is a pro-active
approach to pollution prevention
It targets pollution at the design
stage, before it even begins.
It is designing chemical produts
and processes that reduce or
eliminate the use and the
generation of hazardous
substances.

6. PRINCIPLES OF GREEN
CHEMISTRY
 Waste reduction in chemical synthesis
 Using rawmaterials and feedstocks
from renewable sources
 Employing catalysts.
 Avoiding chemical derivatives.
 Maximising atom economy

7. Replacing or reducing solvents.
Increasing energy efficiency of
chemical reactions
Using in-process or real time
monitoring.
Other process safety and
environmental consideration.

9. GREEN CHEMISTRY IN
PHARMACEUTICAL
 Currently,the pharma industry is trying
to curb spending in the industry.
 Green chemistry offers significant cost
advantages.
 Compared with other sectors in its
green practices,the pharma ranks low
 The E-factor

11. AMERICAN CHEMICAL SOCIETY GREEN
CHEMISTRY INSTITUTE [ACSGCI]
 In 2005,several firms along with
ACSGCI established the GCI
Phrmaceutical Round table
[ACSGCIPR].
 The major companies included in this
are
Pfizer,Johnson&Johnson, Astrazeneca,
GalaxoSmithKline etc.
 They reviewed work in 14 areas.

12. THE AREAS REVIEWED BY
ACSGCIPR
Solvent reduction or replacement.
Oxidation
Amide formation
Assymetric hydrogenations
Flourination
Carbon-hydrogen activation
Bio catalysis
Chemistry in water
Alcohol activation for nucleophilic displacem’t
Friedel-crafts chemistry
Continous processing intensification
Supercritical fluid chromatography separation

13. GSK’S ECO-DESIGN TOOL KIT
 A Green chemistry &technological guide
 A material guide to solvents & bases with
related environmental health &safety data
 A fast lifecycle assesment for synthetic
chemistry that streamlines evaluations of
environmental lifecycle & measures green
metrics
 A green packaging guide
 A guide that identifies legislation phasing out
hazardous substances

14. SOME HIGH PROFILE SUCCESSES IN
PHARMACEUTICAL INDUSTRY
 Rochebetters route for Pyridinylimadazole –
based drug.
 Merck’s green process for Raltegravir
 Pfizer’s green synthesis of Pregabalin
 Eli
Lilly optimizes production of neurokinin-1
antagonist