Future of white biotechnology in china 2nd edition

CCM Data & Primary Intelligence

Future of White Biotechnology in China

The Second Edition

Researched & Prepared by:

Guangzhou CCM Information Science and Technology Co., Ltd
Guangzhou, P. R. China

Sep. 2009

Copyright by Guangzhou CCM Information Science & Technology Co., Ltd. (P. R.
China)
Any publication, distribution or copying of the content in this report is prohibited.
Website: http://www.cnchemicals.com
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Email: econtact@cnchemicals.com

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Description:

Description of Future of White Biotechnology in China

The first edition of this report was finished in April 2008, with 310 pages length in Word Form. The
second edition, with content improved and more insightful views, will come out soon this year. The
report is the only one and the latest one available in the world to provide good understanding about the
white biotechnology in China and to find out the business opportunities in this field.

- 4 reasons to carry out thisν research

White biotechnology developing fast in China
Short supply of energy and fossil materials
Government supports WB industry
Huge opportunities

Major achievements in White Technology inν China in recent years
Fuel ethanol produced from non-food renewable materials
Super yeast with higher ethanol tolerance (15%~17% ethanol concentration), used in fuel ethanol
production
Pilot production of fuel ethanol using cellulosic materials
Biomaterials, such as PHA and PLA, were introduced into the market
Some bio-based chemicals, such as di-acids, 1,3-PDO, acrylamide and xanthan gum have been
developed.
Technology of some bio-based chemicals was greatly improved, especially that of vitamins.

- What is covered?

Policies and regulations on renewable feedstock, WB products, environmental protection, subsidies,
incentives, etc.

Renewable feedstock planting and supply situation in China. Over 15 major renewable feedstock
essential to white biotechnology including the categories of main-food materials, non-food materials,
vegetable oils and cellulosic materials are summarized.

Market info of key WB products. The market data, major players, technical suppliers, technologies or
R&D situations are included. Over 30 WB-related products are summarized falling into the categories
of bio-fuels, bio-materials, bio-products and bio-based chemicals.

Overview of white biotechnology. Latest market value estimation breakdown by category, cutting-edge
technology developments, development environments analysis, SWOT analysis.

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Future prospects of white biotechnology, supply and demand forecasts on major products or categories,
prospects on potential WB products, key drivers, bottlenecks, and opportunities.

Driven forces and key factors for the development of white biotechnology.

Opportunities in white biotechnology and recommendations.

Profiles of the major players, researching institutes, top scientists.

Supporting materials like water, energy, labor cost in different locations in China.

What are the benefits of the report?

Gain a clear understanding of the industry landscape and the latest developments in R&D, production,
technology advances and future trends in industrial biotechnology in China
Know the development stages and international status of key WB products of China based on basic
data and latest info
Get reasonable and constructive suggestions on the market opportunities in WB fields in China
Understand the overall situation of renewable materials supply situation in China based on
comprehensive and integrated data
Get a thorough analysis of the market place for industrial biotechnology in China, the current trend and
future growth prospects
Learn more about the latest advances in commercialization of WB products within China and how
policies and incentives that can encourage growth
Know more about how innovative players and research groups are driving innovation, collaboration and
achieving commercial success in China

- What’s new in this edition?

The updated edition will be strengthened over the last edition mainly from the aspects of:
● Volume and value of market size, production, etc. will be presented.
● Estimates on the market size of white biotechnology in China will be provided, and breakdown by
major categories.
● Forecasts will be more detailed.
● Overview of the cutting-edge technology developments, SWOT analysis, and development
environments of China’s white biotechnology will be provided.

Besides, some other significant differences from the previous version are listed as follows:

Table 1 Differences between new edition and the previous edition
Items New edition Previous edition
Methodology: questionnaire survey Yes No
Chapter III: Overview … Yes No
Products: Di-acid, PHA Existing commercial Emerging commercial

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Products: Acrylamide, PLA Existing commercial No
Products: antibiotics No (*) Existing commercial

* It will be described in the coming planned reports Red Biotechnology in China and Green
Biotechnology in China provided by CCM

- Methodologies and approaches
Scientific methodologies and varieties of data sources are adopted to ensure the credibility.
Major steps adopted to formulize this report:
Desk research
Telephone interviews with WB players and researchers through telephone
Questionnaires were sent to many WB players to ask for their opinions
Import and Export analysis to demonstrate the trade situation and also help analyse the production and
consumption situation
Series of internal discussions in order to analyse the data and draw conclusions from it
Forecasting
Report generation

The data collected and compiled were sourced from:
Published articles from periodicals, magazines, journals, the third database
Government statistics
Primary info obtained by Tel-interviews, on-line chats, emails, questionnaires, etc.
Comments from industrial experts
Import and export data from customs
CCM’s database
Third-parties’ database
Information from the Internet

Data from various channels has been combined and cross-checked to make this report as precise and
credible as possible.

Who needs to subscribe this report?

Biotechnology companies
Update your knowledge and notice the latest developments of theω market, R&D and applications in
China
Discover the potentialω opportunities for white biotechnology in China
Benefit from a thoroughω review of new applications for bio-based products and assess the potential
for the further growth of your company
Chemicals and plastic companies
Learn how white biotechnologies and renewable raw materials willω change the status quo of this
industry and its future
Keep informed ofω recent developments of white biotechnology in China
End users of bio-based products

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Know what superior and novel WB products you can get from Chinaω and then create more value to
your customers and present commercial opportunities for you
Research organizations and academies
Know theω latest technical developments and the newest scientific breakthroughs
Identify the most significant commercial opportunities toω steer future research

Main content:

No. Content Page
Executive summary 1
Introduction and methodology 4
I Governmental regulations on white biotechnology 7
I-1 Regulations on white biotechnology, feedstock and products 7
I-2 Environmental regulations 16
I-3 Subsidies and incentives 20
I-4 Other regulations (industry standards, etc.) 25
I-5 Entry barriers/regulations 27
II Renewable feedstock supply in China 29
II-1 Overview of renewable feedstock planting and supply 29
II-2 Introduction to each renewable feedstock 32
II-2.1 Food feedstock 32
II-2.1.1 Corn 32
II-2.1.2 Sugar 41
II-2.1.3 Wheat 47
II-2.1.4 Rice 52
II-2.2 Non-food feedstock 56
II-2.2.1 Cassava 56
II-2.2.2 Molasses 61
II-2.2.3 Sweet potato 66
II-2.2.4 Sweet sorghum 67
II-2.3 Vegetable & animal oils 69
II-2.3.1 Soybean oil 69
II-2.3.2 Rapeseed oil 75
II-2.3.3 Animal oil 79
II-2.4 Lignocellulosic raw materials 80
II-2.4.1 Corn cob 80
II-2.4.2 Corn stover 87
II-2.4.3 Wheat/rice straw 89
II-2.4.4 Wood wastes 90
III Overview of white biotechnology industry in China 91

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III-1 Market value estimation brokendown by category 91
III-2 Cutting-edge technology development 92
III-3 Development environment analysis 93
III-4 SWOT analysis of China’s white biotechnology 94
IV Key WB products 96
IV-1 Existing commercial products 96
IV-1.1 Bio-products 96
IV-1.1.1 Yeast 96
IV-1.1.2 Enzymes 102
IV-1.1.2.1 α-Amylase 102
IV-1.1.2.2 Gluco-amylase 107
IV-1.1.2.3 Lipase 111
IV-1.1.2.4 Pectinase 115
IV-1.2 Bio-fuels 119
IV-1.2.1 Fuel ethanol 119
IV-1.2.2 Bio-diesel 123
IV-1.3 Bio-based fine chemicals 131
IV-1.3.1 Lactic acid 131
IV-1.3.2 Amino acids 139
IV-1.3.2.1 MSG 139
IV-1.3.2.2 Lysine 145
IV-1.3.3 Nucleic acid 149
IV-1.3.4 Polysaccharides 153
IV-1.3.5 Vitamins 157
IV-1.3.5.1 Inositol 157
IV-1.3.5.2 Vitamin C 162
IV-1.3.5.3 Vitamin B 169
IV-1.4 Bio-based chemicals 173
IV-1.4.1 Acrylamide 173
IV-1.4.2 Di-acids 177
IV-1.4.3 Itaconic acid 183
IV-1.4.4 Butanol 189
IV-1.4.5 Acetone 192
IV-1.5 Bio-materials 195
IV-1.5.1 PHA 195
IV-1.5.2 PLA 202
IV-2 Emerging commercial products 206
IV-2.1 Bio-products 206
IV-2.1.1 C5/C6 yeast 206
IV-2.1.2 Lignocellulosic enzyme 210

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IV-2.2 Bio-based chemicals 214
IV-2.2.1 1,3-PDO 214
IV-2.2.2 Succinic acid 219
IV-3 Potential products 226
IV-3.1 C3 platform 226
IV-3.1.1 Acrylic acid 226
IV-3.1.2 3-HPA 235
IV-3.2 Caprolactam 241
V Key WB players and researchers 251
V-1 Top 5 SOC players 251
V-2 Top 5 private companies 262
V-3 Top 5 MNC players 268
V-4 Startup players 275
V-5 Key WB research groups, technical suppliers and top researchers 282
VI Future prospects 293
VI-1 Drivers and barriers 293
VI-1.1 Drivers 293
VI-1.2 Barriers 295
VI-2 Future prospects 297
VI-2.1 Supply & demand forecast breakdown by category to next 5~10 years 298
VI-2.2 Prospects on the potential products to be commercialized in future 307
VII Conclusion and recommendation (SWOT analysis for each recommendation) 308
VII-1 Conclusion 308
VII-2 Recommendation 310
VIII Appendix 313
VIII-1 Water, energy and labor cost in different areas of China 313
VIII-1.1 Water cost in different areas of China 314
VIII-1.2 Energy cost in different areas of China 315
VIII-1.3 Labor cost in different areas of China 316

Executive summary:

White biotechnology (WB) industry, which is often referred to the third wave in biotechnology, is one of
the most promising new approaches to pollution prevention, resource conservation, and cost reduction
around the world. Eying the huge economic benefit, environmental benefit and social benefit from WB
industry, China has paid great attention to WB industry development. In the last two decades, WB
industry in China has developed at a rapid clip.

Chinese government has paid a crucial influence on WB industry by providing various supports,
including monetary incentives and preferential taxation policies on feedstock, supply and demand of
WB products, etc. Great achievement has been made in WB industry, especially in bio-energy and

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chemical industries. For instance, China has enhanced its global status to the third largest ethanol
producer and the second largest producer of chemicals across the world.

The great achievement in China has generated huge profit. In XX, the market value of China’s WB
industry reached USDXX billion, including market value of USDXX billion accounting for around XX% of
the total from bio-based fine products, the largest WB category in China.

As for WB technology development, China has accomplished the breakthrough in major technologies
including strain engineering, optimization of fermentation technology, immobilized enzyme and cell
technology, separation and extraction technology, and optimization of bioreactors in China. Application
of fermentation and bio-catalysis technology in high-value and low-volume products in China has seen
great success in the past few decades.

Thanks to the technoogy development, the number of biotechnology industrial products has increased
significantly and their production scales have been enlarged a lot. Major WB products in China are
traditional fermentation products, such as enzymes, vitamins, amino acids, organic acids, starch
derivatives, etc. For brand-new WB products, such as PHA, 1,3-PDO, di-acids and bio-energy, are all
at introduction stage. Based on the previous experiences of successful technology application, more
WB products are likely to be commercialized in the future in China.

Feedstock supply has been one of the focuses of Chinese government’s efforts to boost WB industry
development. Renewable feedstock supply in China can basically meet domestic demand from WB
insustry at present. Food feedstock, such as corn, sugar, wheat and rice, is the most widely adopted in
WB industry as the supply of food feedstock is abundant and the production technology of their
downstream products have been mature. But China’s huge population and limited arable land
determines that the use of food feedstock will not be encouraged for food security concern. Hence,
China has issued many relevant policies on the use of food feedstock for industrial purpose. And the
use of non-food feedstocks such as cassava, Jatropha curcas L., etc, have been actively promoted in
China now.

Character of CCM' Report:

The aim of this report is to provide powerful assistance to the strategy group and the management
team in making correct decision as how to penetrate the ever-increasing China market and how to
catch the maximum commercial opportunities. The report is formulated independently by CCM’s
professional market researchers, based on the first-hand and primary data which are analyzed by
scientific methodology, confirmed with both manufacturers/end users/traders and legal authorities, and
presented in a logic way.

Sample pages:

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………...

- Industry standards
…………

Most of the WB products in China have their own industry standard. The industry standards for
main WB products mentioned in this report are shown as Table I-4.1

Table I-4.1 Industry standards for main WB products
No. Product Industry standard
1 MSG XX

2 Vitamin C XX

3 Vitamin B1 XX

4 α-Amylase XX

5 Gluco-amylase XX

6 Pectinase XX

7 Lipase XX

8 Itaconic acid XX

9 Acetone XX

10 Butanol XX

11 Lactic acid XX

12 Denatured fuel ethanol XX

13 Ethanol Gasoline XX

Source: CCM International

……………

III Overview of White Biotechnology industry in China

III-1 Market value estimation breakdown by category
…………..
WB industry has been one of the emerging biotechnology industries in China. WB industry
took up XX% of the market size of biotechnology industry in China in 2008, from XX% in 2004.

Table III-1.1 Market value of WB industry broken down by categories in China, million USD,
2004-2008
White biotechnology
Year Bio-based Biotechnology
Bio-fuel Bio-based fine product Biomaterial Bio products Total
chemicals

2004 XX XX XX XX XX XX XX






…………

III-4 SWOT analysis of China’s white biotechnology
…………
By analyzing strength, weakness, opportunity and threat of WB industry in China, a clear
picture of the future prospect for WB industry can be gained.

Figure III-4.1 SWOT analysis of China’s white biotechnology

Opportunity
Strength

Threat

WB

Weakness


………….

Table VII-1.1 Situation of major WB products in China
Environment Status in the
Industrial stage Products Market Technology barrier
protection requirement world
XX Domestic Low Modest Equal
Maturity

XX Domestic High High Equal


XX Oversea Modest Modest Leading

XX Oversea High Modest Leading

XX Oversea High Modest Leading
Growth XX Domestic High Modest Leading

XX Oversea Modest Low Equal

XX Domestic Modest Low Equal


XX Domestic High Low Draggled

XX Oversea Low Low Leading

XX Domestic High Modest Equal

XX Domestic Low Low Draggled

XX Domestic Modest Low Draggled

XX Domestic Modest Modest Equal
Introduction XX Domestic Modest Modest Equal

XX Oversea High Modest Equal

XX Oversea High Modest Equal

XX Oversea High Low Equal

XX Oversea High Low Leading

XX - High - Draggled
Developing XX - High - Draggled

XX Domestic Modest Modest Draggled

Little research XX - High - Draggled

No research XX Domestic High Modest Draggled


Future of white biotechnology in china 2nd edition

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