Lo mejor en riesgo cardiovascular
Dra. Pilar Mazón Ramos, Complejo Hospitalario Universitario de Santiago de Compostela
Lo mejor del Congreso ESC Barcelona 2017
06/09/2017 20:00
http://esc17.secardiologia.es
#PostESC17
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Lo mejor en riesgo cardiovascular. Lo mejor del Congreso ESC Barcelona 2017
1. Lo mejor del Congreso ESC Barcelona 2017
Lo mejor en
Riesgo Cardiovascular
Pilar Mazón
Hospital Clínico Universitario
Santiago de Compostela
2. Lo mejor del Congreso ESC Barcelona 2017
Lo mejor en Riesgo Cardiovascular
CANTOS
HPS3-TIMI 55 REVEAL
FOURIER (Update)
SPYRAL HTN OFF-MED
PURE
Guías DAPT
….
8. Lo mejor del Congreso ESC Barcelona 2017
In conclusion, these randomized placebo-controlled trial data demonstrate
that targeting the IL-1b to IL-6 pathway of innate immunity with
canakinumab reduces cardiovascular event rates and potentially reduces
rates of incident lung cancer and lung cancer mortality. These data provide
proof that inflammation inhibition, in the absence of lipid lowering, can
improve atherothrombotic outcomes and potentially alter the progression of
some fatal cancers
9. Lo mejor del Congreso ESC Barcelona 2017
→ 30.449 ptes > 50 años con enfermedad vascular establecida
(88% enf coronaria / 22 % cerebrovascular / 8% periférica / 37 % diabetes)
→ Tto basal ATORVASTATINA 20 u 80 mg (China: 10 o 20 mg)
→ ANACETRAPIB vs PLACEBO
→ Objetivo 1ario : Muerte coronaria, IAM o revascularización coronaria
13. Lo mejor del Congreso ESC Barcelona 2017
Among patients with atherosclerotic vascular disease
who were receiving intensive statin therapy, the use of
anacetrapib resulted in a lower incidence of major
coronary events than the use of placebo
17. Lo mejor del Congreso ESC Barcelona 2017
There was a monotonic relationship between achieved LDL cholesterol and
major cardiovascular outcomes down to LDL-cholesterol concentrations of
less than 0·2 mmol/L. Conversely, there were no safety concerns with very
low LDL-cholesterol concentrations over a median of 2·2 years. These data
support further LDL-cholesterol lowering in patients with cardiovascular
disease to well below current recommendations.
18. Lo mejor del Congreso ESC Barcelona 2017
Further Cardiovascular OUtcomes Research With
PCSK9 Inhibition in Subjects With Elevated Risk
(Focus on Cerebrovascular Disease)
→ 5.337 ptes con antecedente de Ictus
MISMOS RESULTADOS DE EFICACIA Y SEGURIDAD
19. Lo mejor del Congreso ESC Barcelona 2017
Expresión de PCSK9 en plaquetas
Rossetti L, 2210
21. Lo mejor del Congreso ESC Barcelona 2017
SPYRAL HTN OFF-MED
22. Lo mejor del Congreso ESC Barcelona 2017
SPYRAL HTN OFF-MED
23. Lo mejor del Congreso ESC Barcelona 2017
Results from SPYRAL HTN-OFF MED provide biological
proof of principle for the blood-pressure lowering
efficacy of renal denervation.
SPYRAL HTN OFF-MED
24. Lo mejor del Congreso ESC Barcelona 2017
High carbohydrate intake was associated with higher risk of total mortality,
whereas total fat and individual types of fat were related to lower total
mortality. Total fat and types of fat were not associated with cardiovascular
disease, myocardial infarction, or cardiovascular disease mortality, whereas
saturated fat had an inverse association with stroke. Global dietary
guidelines should be reconsidered in light of these findings.
25. Lo mejor del Congreso ESC Barcelona 2017
Higher fruit, vegetable, and legume consumption was associated with a
lower risk of non-cardiovascular, and total mortality. Benefits appear to
be maximum for both non-cardiovascular mortality and total mortality
at three to four servings per day (equivalent to 375–500 g/day).