Seminario molecular

“ INCREASED PROTHROMBIN, APOLIPOPROTEIN A-IV, AND HAPTOGLOBIN IN THE CEREBROESPINAL FLUID OF PATIENTS WITH HUNTINGTON´S DISEASE.” Yen-Chu Huang . Maria Camila Montufar Pantoja Heyly Milena Ortega III SEMESTER 2011 UNIVERSIDAD PONTIFICIA BOLIVARIANA

GENERAL OBJETIVE ,[object Object]

INTRODUCTION ,[object Object],[object Object]

PROTHROMBIN ,[object Object],[object Object],[object Object],Tromboplastina Ca++ Xa Va

APOLIPOPROTEIN AIV (APO AIV) ,[object Object],[object Object],[object Object],[object Object]

HAPTOGLOBIN ,[object Object],[object Object],[object Object],[object Object]

HUNITNGTON DISEASE - HD ,[object Object],[object Object]

MATERIALES Y METODOS ,[object Object],[object Object],[object Object],[object Object],[object Object],PREPARACION DE LAS MUESTRAS

ELECTROFORESIS DE DOS DIMENSIONES (2-DE ) ,[object Object],[object Object],[object Object],[object Object]

DIGESTION EL GEL ,[object Object],[object Object],[object Object],[object Object],[object Object]

ESPECTROMETRIA DE MASA ,[object Object],[object Object],[object Object]

WESTERN BLOT ,[object Object],[object Object],[object Object],[object Object]

ELISA ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

DISCUSSION AUTOR OPINION YES NO Bjorkqvist M. The mutant huntingtin may enchance the ability of microglia to produce proinflamatory mediators (IL-6, IL-8 and TNF-a) and contribute to neurodegeneration in HD. Djoussé L. In HD, weigth loss is a characteristic feature in advanced as well early stage. Fang Q, Strand In proteome analyses several the neuronal proteins were found to be reduced Underwood BR A serum metabolic profile indicative of a pro-catabolic phenotype in early HD

CONCLUTIONS ,[object Object],[object Object]

BIBLIOGRAFIA ,[object Object],[object Object],[object Object]

Seminario molecular

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