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Innovative Science
Affordable Medicine
www.biocon.com
Investor Presentation
July 2014
Certain statements in this release concerning our future growth prospects are forward-looking
statements, which are subject to a number of risks, uncertainties and assumptions that could cause
actual results to differ materially from those contemplated in such forward-looking statements.
Important factors that could cause actual results to differ materially from our expectations include,
amongst others general economic and business conditions in India, our ability to successfully
implement our strategy, our research and development efforts, our growth and expansion plans and
technological changes, changes in the value of the Rupee and other currencies, changes in the Indian
and international interest rates, change in laws and regulations that apply to the Indian and global
biotechnology and pharmaceuticals industries, increasing competition in and the conditions of the
Indian biotechnology and pharmaceuticals industries, changes in political conditions in India and
changes in the foreign exchange control regulations in India. Neither the company, nor its directors and
any of the affiliates have any obligation to update or otherwise revise any statements reflecting
circumstances arising after this date or to reflect the occurrence of underlying events, even if the
underlying assumptions do not come to fruition.
Safe Harbor
2
Biocon: Who are we?
• Small Molecules
• Biosimilars
• Branded Formulations
• Research Services
• Novel Molecules
Growth Segments
Financials
Outlook
Agenda
3
Biocon: Who are We?
Biocon: Global Ambitions with Indian Roots
Mission: “To be an integrated biotechnology enterprise of global distinction”
Value Creation along 3 axes:
Leveraging the India advantage to deliver high value, licensable R&D assets
Strategic Research and marketing partnerships that provide global access
Reducing therapy costs of chronic diseases. (diabetes, cancer & auto-immune diseases)
5
Evolving with the Times
1978 -
1999
1999 -
2004
2004 -
2009
2009 –
2014
2014 &
Beyond
An Enzymes Company
Revenue: ₹ 320 Million
Building the India Business
and expertise in biologics
Revenue: ₹ 11,940 Million
People: 3,500+
Investment intensive phase with
focus on R&D, capacity
enhancement & partnership
execution
Revenue (FY 14): ₹ 29,332 Million
People: 7,000+
Transforming into a
Biopharma company
Revenues: ₹ 5,490 Million
People: 700+
Unwavering focus through the years on Innovation & Difficult to make, niche
products to create tangible differentiators for sustainable growth
6
Poised for a global
platform with launch of
finished formulations &
biosimilars in regulated
markets
Group Revenue at ₹ 7,420 Million (3% YoY growth)
YoY Growth* across verticals:
EBITDA at ₹ 1,907 Million (EBITDA Margin: 26% )
R&D Expense: ₹ 311 Million (6% of Biopharmaceuticals Revenue)
PAT at ₹ 1,030 Million (PAT Margin: 14% )
Financial
Performance
Q1 FY15 Highlights
7*YoY comparison of Q1 FY15 Sales vs. Q1 FY14 Sales
Business Vertical Absolute Growth (%)
Biopharma (1)
Branded Formulations 10
Biopharmaceuticals 1
Research Services 12
Total Sales 3
Syngene and Bristol Myers Squibb extend research collaboration
Corporate
Milestone
Novel
Molecules
Unlock
Value
through
Licensing
Growth
Verticals
APIs and generic formulations
Small
Molecules
Research
Services
Integrated
offerings
Insulins, MAbs
& Other
Biologics
Biosimilars
(Biologics &
g. Insulins)
Rapidly growing-
India-centric
business
Branded
Formulations
EMERGING MARKETS FOCUS
Growth Verticals: Aligned with Shifting Paradigms
8
Amongst the Top 20 Global Biotech Employers Worldwide
9
*
* Partial List represented here| Source- http://sciencecareers.sciencemag.org/career_magazine/previous_issues/articles/2013_10_25/science.opms.r1300137
Only Asian Company to
appear in the list
– 2 years in a row now
Debuted at # 19 last year
Business Segments: Snapshot
Product Portfolio which leverage our core fermentation capabilities and have a high degree of
complexity.
Early mover in niche products coupled with economies of scale.
Portfolio based Approach.
Making investments' to forward integrate from APIs to generic formulations, including ANDAs.
Small Molecules: APIs & Generics
APIs
(Generic & Novel)
Generic Formulations
(Including ANDAs)
Current Portfolio Constituents
Statins Simvastatin, Atorvastatin, Lovastatin, Rosuvastatin, Fluvastatin & Pravastatin
Immuno suppressants Tacrolimus, Sirolimus, MMF & MPA
Other Biopharma Orlistat, Fidaxomicin, 50+ other molecules
11
Biosimilars: Demystifying
“a biological product that is highly similar to the reference product notwithstanding
minor differences in clinically inactive components, and.. no clinically meaningful
differences against the reference product in terms of the safety, purity and potency.”
Large Molecules (proteins): greater complexity
Extensive development process
Process development and Capacity constraints
g. rh-Insulin & g. Insulin Analogs (insulin glargine, insulin lispro & insulin aspart)
Monoclonal Antibodies (Trastuzumab, Bevacizumab, Adalimumab)
Other Biologics (Etanercept, Peg-filgrastim)
A
biosimilar
is…
Unlike a
small
molecule…
Current
Portfolio
Biosimilar Definition: Biologics Price Competition and Innovation Act of 2009 12
Biosimilars: Opportunity
Total Insulins
Market:
~ USD 21 Bn*
The Insulin Pie Biosimilar MAbs & Other Biologics
Opportunity :
~ USD 37 Bn*
*Market Size of innovator products MAT March 2014, All figures rounded off to nearest USD Billion, %ages on absolute numbers 13
rh-Insulin
~ 3 Bn, 16%
glargine
~8 Bn, 37%
lispro
~3 Bn, 12%
Aspart
~5 Bn, 22%
detemir
~ 2 Bn, 10%
glulisine
~0.4 Bn, 2%
trastuzumab
~7 Bn, 18%
bevacizumab
~7 Bn, 18%
etanercept
~8 Bn, 22%
peg-
filgrastim ~4
Bn, 12%
adalimumab
~11 Bn, 30%
Portfolio Biosimilar Molecule
Global Trials
Generic Insulins
rh- Insulin
Glargine
Lispro & Aspart
Biosimilar MAbs
and other
biologics
Trastuzumab
Bevacizumab, Adalimumab
Etanercept, Peg-filgrastim
Process Development /
Scale-up / Preclinical
Phase
1/II b
Market
Phase
III
Emerging Markets First strategy coupled with a regional partnership commercialization approach
Launched the world’s most affordable trastuzumab, CANMAb™ in India, in Q4 of fiscal 2014
Generic rh Insulin registered in 55+ countries; generic insulin glargine registered in 10+ nations
14
Biosimilars: Pipeline
6%
11%
84%
Biosimilars: Key Emerging Market Footprint
Sept’ 2013
Innovators
Biocon
Others
86%
4%
9%
Mar’ 2009
*IMS MAT for respective years in Key emerging markets where we have a presence
rh-Insulin Volume Market Share: Evolution
2009 – 2013 Key Emerging Markets Innovators Biocon Others
CAGR over 5 year 11% 10% 32% -
15
Combines Biocon's R&D and manufacturing prowess of
biologics with Mylan’s regulatory & commercialization
capabilities in the US and Europe
*Market Size of innovator products in the current portfolio: Innovator Sales MAT March 2014
Generic Insulin Analogs Biosimilar MAbs & other Biologics
Global Market Size * ~ USD 18 Bn ~ USD 37 Bn
Portfolio Constituents Glargine, Lispro & Aspart
Trastuzumab, Bevacizumab, Adalimumab,
Eternacept, Peg-filgrastim
Mylan’s Exclusive
Commercialization Regions
US, Canada, Europe, Australia
& New Zealand
Developed markets
Upfront Received $ 20 Mn $ 18 Mn
Structure: Upfront Payment + Cost Sharing + Supplies + Profit Sharing#
Mylan and Biocon to share development and capital costs
#Profit Sharing Arrangement in regions where Mylan has exclusive commercialization rights
Biocon and Mylan have co-exclusive commercialization rights in other markets.
Co-Development & Commercialization Partnership
16
Biosimilars: Collaboration
Biocon’s First Manufacturing expansion overseas : Iskandar, Johor
Asia’s largest integrated Insulins manufacturing facility
Investment to the tune of ~$ 200 Mn in the first phase
Expected Commissioning: FY15
Key Highlights
Malaysia Insulin Facility
17
 An India Centric Business with Global Ambitions
 Organized into 5 verticals around key therapy areas
 Portfolio highlights:
 Insugen® & Basalog®: India’s largest selling
generic insulin & long acting analog
 BioMAb EGFR®: India’s 1st indigenous novel MAb
for head & neck cancer
 Alzumab™: India’s 2nd indigenous novel MAb for
Psoriasis
 CANMAb™: World’s most affordable trastuzumab
to be commercialized
 Cytosorb®: First-in-class Cytokine Filter
Branded Formulations: Introduction
18
CV-Met Cancer Therapies Autoimmune
Hospital: Critical CareRenal Therapies
Branded Formulations: Key Brands
19
Branded Formulations: Sustained Growth
20
Revenues in ₹ Million
Q1
9
4
6
7
10
17
8
15
12
10
Q1 FY14 Q2 FY14 Q3 FY14 Q4 FY14 Q1 FY15
IPM Biocon
Revenue over the years Revenue Growth benchmarking
650
860 1,007
1,944
2,614
2,907
2,594
3,474
3,914
1,106
FY12 FY13 FY14 FY15
Branded Formulations: Alzumab™
First-in-Class Therapy :Novel MOA with an excellent safety profile
Excellent clinical remission & safety data in phase III for Psoriasis
Very low Infection rates vis-à-vis other approved therapies
Modulates TH17 Pathway: Frontrunner in the hot bed of research in auto
immune space
Commercialised in India post a successful Phase III trial in Psoriasis (200+
patients);
Promising preclinical and clinical efficacy data in other auto immune diseases
(Rheumatoid Arthritis, Psoriatic Arthritis etc)
Key Differentiators
21
Branded Formulations: CANMAb™
Key Differentiators
Approved after a Phase 3 (130 + patient) trial in India
Available in India from February 2014
C: Convenience -- Available in unique combination of multi-dose vial of 150 mg & 440 mg
A: Affordability
• MRP – Rs 57,500 for 440mg vial, Rs 19,500 for 150mg vial
• Availability of 150 mg multi-dose vial allows patients to save money by buying smaller
quantities, and storing unused product for their next dose rather than wasting it
N: New from India-- World’s most affordable trastuzumab to be commercialized
22
Novel Molecules: Pipeline
Therapeutic Area Molecule
Oncology Nimotuzumab
Autoimmune Itolizumab
Ophthalmology QPI-1007
Oncology ADXS–HPV
Diabetes IN-105
Oncology Anti CD – 20
Oncology Fusion Proteins
Pre-
Clinical
Phase
II
Phase
1
Market
Phase
III
Discovery
#
23
Currently on hold
Commercialized in India
Commercialized in India
Biocon will continue global development of the molecule through Phase II
via redesigned trials.
Partnership encompasses Financial, Strategic and Clinical Support
throughout the development phase
BMS will have an exclusive option post phase II to further develop &
commercialise the asset worldwide (excl. India)
Biocon will receive licensing fee in addition to potential regulatory &
commercialization milestones, when BMS exercises its option
Combines Biocon's novel asset and development
experience with BMS’ novel drug development,
regulatory & commercialization capabilities.
Novel Molecules: Collaboration
IN-105 Option Agreement: BMS (First-in-Class Oral Prandial Insulin)
24
Research Services: Snapshot
2000
Today
India’s largest CRO with 2,000 + scientists,
working with 16 of the Top 20 pharma
companies in the world.
Capital Investment of ~$130 Mn
An investment of ~$20 Mn supported
by 100+ scientists focused on building
a world class CRO
25
Customized
models
Evolving
Services
Niche
Offerings
Integrated
Platforms
o Bioanalytical testing of small and large molecules
o Antibody Drug Conjugate (ADC) development
o Unique In-Vivo Models- Human tumour tissue Xenograft
o Early and rapid toxicology evaluation (Cardiomyocytes )
o Commercial scale production of NCEs
o High potency (cytotoxic) API manufacturing
o Formulation development
o Dedicated/customized infrastructure
o End-to-end services
o Risk sharing: Milestone based
o Incubation: IP sharing
o Integrated Drug Discovery and Development
o Biologics Discovery and Development
o Syngene- Clinigene axis
Research Services: Capabilities & Collaboration Models
26
Research Services: Key Customers
Largest R&D Centre by a Big Pharma
in Asia (started in 2009, contract
extended to 2020)
Dedicated centre of research
excellence with world class facilities
Over 400 scientists supporting Novel
Molecule research in small and large
molecules
Integrated drug discovery &
development across various
therapeutic areas
Baxter’s 1st research centre in India
in partnership with Syngene (2014)
State of the art facility supporting
R&D of medical products and devices
Engages a multidisciplinary team of
over 100 scientists
R&D activities centred on product
and analytical development,
preclinical evaluation in parenteral
nutrition and renal therapy
Abbott Nutrition’s 1st R&D centre in
India set up in collaboration with
Syngene (2012)
Dedicated centre supporting
development of nutrition products
Over 30 multi-disciplinary scientists
engaged in product development
lifecycle
Focus on maternal, paediatric, neo-
natal nutrition and diabetes care in
line with emerging market needs
27
Research Services: Performance
o PE Investment of ₹ 1,250 Million
for a 7.69% stake, assigning
Syngene a post money valuation
of ₹16,250 Million
o Investment earmarked for
enhancing Syngene’s service
offerings, capacities & fund future
growth
o GE brings in corporate best
practices along with avenues for
capability enhancement and new
offerings
28
Revenues in ₹ Million
720 874
1,224 1,542
3,177
4,101
5,572
7,146
1,723
FY11 FY12 FY13 FY14 FY15
Q1
Financials
Revenue 14,930 318 18,579 407 21,483 445 25,380 467 29,332 487
R&D Spend 785 17 1,183 26 1,366 28 1,640 30 1,310 22
EBITDA 4,551 97 5,733 125 5,791 120 5,957 110 7,429 123
Net profit* 2,729 58 3,399 74 3,384 70 3,241 60 4,137 69
EPS (FV: ₹ 5) 13.6 17.0 16.9 25.4 20.7
FY10 FY11 FY12 FY13
FY10-14: Avg.exch.rate in that fiscal ; Q1 FY14: USD 1 = ₹ 55.87; Q1 FY15: USD 1= ₹ 59.88
# Biopharmaceutical Sales including Branded Formulations |* Net Profit Pre exceptional items
Financial Performance
Q1 FY15 Q1 FY14
Revenue 7,420 | 124 7,234 | 129
R&D Spends 311 | 5 431 | 8
% of Biopharmaceutical Sales # 6% 8%
EBITDA 1,907| 32 1,753| 31
EBITDA Margin 26% 24%
Net Profit 1,030| 17 942| 17
PAT Margin 14% 13%
EPS 5.2 4.7
All Figures in ₹ Millions /USD Mn except EPS
FY14
30
Core Business Margins: Detailed
FY 10 FY 11 FY 12 FY 13 FY 14 Q1 FY15
Revenue 14,930 18,579 21,483 25,380 29,332 7,420
Less: Other Income 324 516 993 1,103 804 234
Less: Licensing Income 507 1,525 1,266 246 149 190
Core Revenues 14,099 16,538 19,224 24,031 28,379 6,996
EBITDA 4,551 5,733 5,791 5,957 7,429 1,907
Add: R&D Expense 785 1,183 1,366 1,640 1,310 311
Less: Other Income 324 516 993 1,103 804 234
Less: Licensing Income 507 1,525 1,266 246 149 190
Net EBITDA 4,505 4,875 4,899 6,248 7,786 1,794
Net EBITDA Margin 32% 29% 25% 26% 27% 26%
31
India
39%
Ex India
61%
12%
4,317 4,167
80 190
1,007 1,106
1,542 1,723
288
234
7,234
7,420
Q1 FY14 Q1 FY15
Revenue: Detailed
32
All Figures in ₹ Millions unless otherwise specified
Core
Biopharma
Licensing
Branded
Formulations
Research
Services
Other
Income
Geography Wise
Sales Breakup:
₹ 7,186
(3)%
3%
10%
Outlook
o Small Molecules - Improved product Mix
o Biosimilars - Geographical Expansion in semi regulated
and regulated markets
o Branded Formulations - Differentiated Value offerings
o Research Services - Sustained Growth Momentum
o Novel Molecules - Out-licensing and Global Development
Growth drivers supplemented by addition of new offerings (products, services & partnerships)
Key Focus Areas
34
Aspiring for $1 Billion in Revenues in 2018
Exchange Rate: 1 USD =₹ 50
30%
20%
20%
25%
5%
2018 E
$1 Billion +
~61% | Promoters
~ 8 % | Employees & ESOP trust
~31 % | Public
Biocon
Business Structure & Holdings
Syngene International, India | ~88%
Custom research, drug discovery
Clinigene International, India | 100%
Clinical development
Biocon Research , India | 100%
R&D- Novel Molecules & Biosimilars
Biocon Sdn. Bhd, Malaysia | 100%
Overseas subsidiary
Biocon SA, Switzerland | 100%
Overseas subsidiary
NeoBiocon, UAE | 50%
Overseas subsidiary
BIOPHARMA SUBSIDIARIES
RESEARCH SERVICES
Spanning the entire Value Chain with capabilities ranging from
discovery to manufacturing
35
36
Saurabh Paliwal
Tel : +91 80 2808 2808, Ext 2040
Tel Direct : +91 80 2808 2040
saurabh.paliwal@biocon.com
Sweta Pachlangiya
Tel : +91 80 2808 2808, Ext 5481
Tel Direct : +91 80 2808 5481
sweta.pachlangiya@syngeneintl.com
Investor Contacts
For updates and specific queries, please visit www.biocon.com
or contact
Appendix
37
The Biologics Opportunity: Top Selling products 2013
# Drug Name Nature 2013 Sales 2009 Sales CAGR (%)
1 Humira MAb 11.0 5.6 19
2 Enbrel Recombinant product 8.8 6.5 8
3 Remicade MAb 8.4 5.9 9
4 Advair Small Molecules 8.3 8.0 1
5 Lantus Recombinant product 7.6 4.3 15
6 Rituxan MAb 7.5 5.6 7
7 Avastin MAb 6.8 5.7 4
8 Herceptin MAb 6.6 4.9 8
9 Januvia Small Molecule 6.2 1.9 34
10 Crestor Small Molecule 6.1 4.8 6
38
5/9 molecules in our biosimilar portfolio are part the global top-10 selling drugs list

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Biocon Investor's Presentation July 2014

  • 2. Certain statements in this release concerning our future growth prospects are forward-looking statements, which are subject to a number of risks, uncertainties and assumptions that could cause actual results to differ materially from those contemplated in such forward-looking statements. Important factors that could cause actual results to differ materially from our expectations include, amongst others general economic and business conditions in India, our ability to successfully implement our strategy, our research and development efforts, our growth and expansion plans and technological changes, changes in the value of the Rupee and other currencies, changes in the Indian and international interest rates, change in laws and regulations that apply to the Indian and global biotechnology and pharmaceuticals industries, increasing competition in and the conditions of the Indian biotechnology and pharmaceuticals industries, changes in political conditions in India and changes in the foreign exchange control regulations in India. Neither the company, nor its directors and any of the affiliates have any obligation to update or otherwise revise any statements reflecting circumstances arising after this date or to reflect the occurrence of underlying events, even if the underlying assumptions do not come to fruition. Safe Harbor 2
  • 3. Biocon: Who are we? • Small Molecules • Biosimilars • Branded Formulations • Research Services • Novel Molecules Growth Segments Financials Outlook Agenda 3
  • 5. Biocon: Global Ambitions with Indian Roots Mission: “To be an integrated biotechnology enterprise of global distinction” Value Creation along 3 axes: Leveraging the India advantage to deliver high value, licensable R&D assets Strategic Research and marketing partnerships that provide global access Reducing therapy costs of chronic diseases. (diabetes, cancer & auto-immune diseases) 5
  • 6. Evolving with the Times 1978 - 1999 1999 - 2004 2004 - 2009 2009 – 2014 2014 & Beyond An Enzymes Company Revenue: ₹ 320 Million Building the India Business and expertise in biologics Revenue: ₹ 11,940 Million People: 3,500+ Investment intensive phase with focus on R&D, capacity enhancement & partnership execution Revenue (FY 14): ₹ 29,332 Million People: 7,000+ Transforming into a Biopharma company Revenues: ₹ 5,490 Million People: 700+ Unwavering focus through the years on Innovation & Difficult to make, niche products to create tangible differentiators for sustainable growth 6 Poised for a global platform with launch of finished formulations & biosimilars in regulated markets
  • 7. Group Revenue at ₹ 7,420 Million (3% YoY growth) YoY Growth* across verticals: EBITDA at ₹ 1,907 Million (EBITDA Margin: 26% ) R&D Expense: ₹ 311 Million (6% of Biopharmaceuticals Revenue) PAT at ₹ 1,030 Million (PAT Margin: 14% ) Financial Performance Q1 FY15 Highlights 7*YoY comparison of Q1 FY15 Sales vs. Q1 FY14 Sales Business Vertical Absolute Growth (%) Biopharma (1) Branded Formulations 10 Biopharmaceuticals 1 Research Services 12 Total Sales 3 Syngene and Bristol Myers Squibb extend research collaboration Corporate Milestone
  • 8. Novel Molecules Unlock Value through Licensing Growth Verticals APIs and generic formulations Small Molecules Research Services Integrated offerings Insulins, MAbs & Other Biologics Biosimilars (Biologics & g. Insulins) Rapidly growing- India-centric business Branded Formulations EMERGING MARKETS FOCUS Growth Verticals: Aligned with Shifting Paradigms 8
  • 9. Amongst the Top 20 Global Biotech Employers Worldwide 9 * * Partial List represented here| Source- http://sciencecareers.sciencemag.org/career_magazine/previous_issues/articles/2013_10_25/science.opms.r1300137 Only Asian Company to appear in the list – 2 years in a row now Debuted at # 19 last year
  • 11. Product Portfolio which leverage our core fermentation capabilities and have a high degree of complexity. Early mover in niche products coupled with economies of scale. Portfolio based Approach. Making investments' to forward integrate from APIs to generic formulations, including ANDAs. Small Molecules: APIs & Generics APIs (Generic & Novel) Generic Formulations (Including ANDAs) Current Portfolio Constituents Statins Simvastatin, Atorvastatin, Lovastatin, Rosuvastatin, Fluvastatin & Pravastatin Immuno suppressants Tacrolimus, Sirolimus, MMF & MPA Other Biopharma Orlistat, Fidaxomicin, 50+ other molecules 11
  • 12. Biosimilars: Demystifying “a biological product that is highly similar to the reference product notwithstanding minor differences in clinically inactive components, and.. no clinically meaningful differences against the reference product in terms of the safety, purity and potency.” Large Molecules (proteins): greater complexity Extensive development process Process development and Capacity constraints g. rh-Insulin & g. Insulin Analogs (insulin glargine, insulin lispro & insulin aspart) Monoclonal Antibodies (Trastuzumab, Bevacizumab, Adalimumab) Other Biologics (Etanercept, Peg-filgrastim) A biosimilar is… Unlike a small molecule… Current Portfolio Biosimilar Definition: Biologics Price Competition and Innovation Act of 2009 12
  • 13. Biosimilars: Opportunity Total Insulins Market: ~ USD 21 Bn* The Insulin Pie Biosimilar MAbs & Other Biologics Opportunity : ~ USD 37 Bn* *Market Size of innovator products MAT March 2014, All figures rounded off to nearest USD Billion, %ages on absolute numbers 13 rh-Insulin ~ 3 Bn, 16% glargine ~8 Bn, 37% lispro ~3 Bn, 12% Aspart ~5 Bn, 22% detemir ~ 2 Bn, 10% glulisine ~0.4 Bn, 2% trastuzumab ~7 Bn, 18% bevacizumab ~7 Bn, 18% etanercept ~8 Bn, 22% peg- filgrastim ~4 Bn, 12% adalimumab ~11 Bn, 30%
  • 14. Portfolio Biosimilar Molecule Global Trials Generic Insulins rh- Insulin Glargine Lispro & Aspart Biosimilar MAbs and other biologics Trastuzumab Bevacizumab, Adalimumab Etanercept, Peg-filgrastim Process Development / Scale-up / Preclinical Phase 1/II b Market Phase III Emerging Markets First strategy coupled with a regional partnership commercialization approach Launched the world’s most affordable trastuzumab, CANMAb™ in India, in Q4 of fiscal 2014 Generic rh Insulin registered in 55+ countries; generic insulin glargine registered in 10+ nations 14 Biosimilars: Pipeline
  • 15. 6% 11% 84% Biosimilars: Key Emerging Market Footprint Sept’ 2013 Innovators Biocon Others 86% 4% 9% Mar’ 2009 *IMS MAT for respective years in Key emerging markets where we have a presence rh-Insulin Volume Market Share: Evolution 2009 – 2013 Key Emerging Markets Innovators Biocon Others CAGR over 5 year 11% 10% 32% - 15
  • 16. Combines Biocon's R&D and manufacturing prowess of biologics with Mylan’s regulatory & commercialization capabilities in the US and Europe *Market Size of innovator products in the current portfolio: Innovator Sales MAT March 2014 Generic Insulin Analogs Biosimilar MAbs & other Biologics Global Market Size * ~ USD 18 Bn ~ USD 37 Bn Portfolio Constituents Glargine, Lispro & Aspart Trastuzumab, Bevacizumab, Adalimumab, Eternacept, Peg-filgrastim Mylan’s Exclusive Commercialization Regions US, Canada, Europe, Australia & New Zealand Developed markets Upfront Received $ 20 Mn $ 18 Mn Structure: Upfront Payment + Cost Sharing + Supplies + Profit Sharing# Mylan and Biocon to share development and capital costs #Profit Sharing Arrangement in regions where Mylan has exclusive commercialization rights Biocon and Mylan have co-exclusive commercialization rights in other markets. Co-Development & Commercialization Partnership 16 Biosimilars: Collaboration
  • 17. Biocon’s First Manufacturing expansion overseas : Iskandar, Johor Asia’s largest integrated Insulins manufacturing facility Investment to the tune of ~$ 200 Mn in the first phase Expected Commissioning: FY15 Key Highlights Malaysia Insulin Facility 17
  • 18.  An India Centric Business with Global Ambitions  Organized into 5 verticals around key therapy areas  Portfolio highlights:  Insugen® & Basalog®: India’s largest selling generic insulin & long acting analog  BioMAb EGFR®: India’s 1st indigenous novel MAb for head & neck cancer  Alzumab™: India’s 2nd indigenous novel MAb for Psoriasis  CANMAb™: World’s most affordable trastuzumab to be commercialized  Cytosorb®: First-in-class Cytokine Filter Branded Formulations: Introduction 18
  • 19. CV-Met Cancer Therapies Autoimmune Hospital: Critical CareRenal Therapies Branded Formulations: Key Brands 19
  • 20. Branded Formulations: Sustained Growth 20 Revenues in ₹ Million Q1 9 4 6 7 10 17 8 15 12 10 Q1 FY14 Q2 FY14 Q3 FY14 Q4 FY14 Q1 FY15 IPM Biocon Revenue over the years Revenue Growth benchmarking 650 860 1,007 1,944 2,614 2,907 2,594 3,474 3,914 1,106 FY12 FY13 FY14 FY15
  • 21. Branded Formulations: Alzumab™ First-in-Class Therapy :Novel MOA with an excellent safety profile Excellent clinical remission & safety data in phase III for Psoriasis Very low Infection rates vis-à-vis other approved therapies Modulates TH17 Pathway: Frontrunner in the hot bed of research in auto immune space Commercialised in India post a successful Phase III trial in Psoriasis (200+ patients); Promising preclinical and clinical efficacy data in other auto immune diseases (Rheumatoid Arthritis, Psoriatic Arthritis etc) Key Differentiators 21
  • 22. Branded Formulations: CANMAb™ Key Differentiators Approved after a Phase 3 (130 + patient) trial in India Available in India from February 2014 C: Convenience -- Available in unique combination of multi-dose vial of 150 mg & 440 mg A: Affordability • MRP – Rs 57,500 for 440mg vial, Rs 19,500 for 150mg vial • Availability of 150 mg multi-dose vial allows patients to save money by buying smaller quantities, and storing unused product for their next dose rather than wasting it N: New from India-- World’s most affordable trastuzumab to be commercialized 22
  • 23. Novel Molecules: Pipeline Therapeutic Area Molecule Oncology Nimotuzumab Autoimmune Itolizumab Ophthalmology QPI-1007 Oncology ADXS–HPV Diabetes IN-105 Oncology Anti CD – 20 Oncology Fusion Proteins Pre- Clinical Phase II Phase 1 Market Phase III Discovery # 23 Currently on hold Commercialized in India Commercialized in India
  • 24. Biocon will continue global development of the molecule through Phase II via redesigned trials. Partnership encompasses Financial, Strategic and Clinical Support throughout the development phase BMS will have an exclusive option post phase II to further develop & commercialise the asset worldwide (excl. India) Biocon will receive licensing fee in addition to potential regulatory & commercialization milestones, when BMS exercises its option Combines Biocon's novel asset and development experience with BMS’ novel drug development, regulatory & commercialization capabilities. Novel Molecules: Collaboration IN-105 Option Agreement: BMS (First-in-Class Oral Prandial Insulin) 24
  • 25. Research Services: Snapshot 2000 Today India’s largest CRO with 2,000 + scientists, working with 16 of the Top 20 pharma companies in the world. Capital Investment of ~$130 Mn An investment of ~$20 Mn supported by 100+ scientists focused on building a world class CRO 25
  • 26. Customized models Evolving Services Niche Offerings Integrated Platforms o Bioanalytical testing of small and large molecules o Antibody Drug Conjugate (ADC) development o Unique In-Vivo Models- Human tumour tissue Xenograft o Early and rapid toxicology evaluation (Cardiomyocytes ) o Commercial scale production of NCEs o High potency (cytotoxic) API manufacturing o Formulation development o Dedicated/customized infrastructure o End-to-end services o Risk sharing: Milestone based o Incubation: IP sharing o Integrated Drug Discovery and Development o Biologics Discovery and Development o Syngene- Clinigene axis Research Services: Capabilities & Collaboration Models 26
  • 27. Research Services: Key Customers Largest R&D Centre by a Big Pharma in Asia (started in 2009, contract extended to 2020) Dedicated centre of research excellence with world class facilities Over 400 scientists supporting Novel Molecule research in small and large molecules Integrated drug discovery & development across various therapeutic areas Baxter’s 1st research centre in India in partnership with Syngene (2014) State of the art facility supporting R&D of medical products and devices Engages a multidisciplinary team of over 100 scientists R&D activities centred on product and analytical development, preclinical evaluation in parenteral nutrition and renal therapy Abbott Nutrition’s 1st R&D centre in India set up in collaboration with Syngene (2012) Dedicated centre supporting development of nutrition products Over 30 multi-disciplinary scientists engaged in product development lifecycle Focus on maternal, paediatric, neo- natal nutrition and diabetes care in line with emerging market needs 27
  • 28. Research Services: Performance o PE Investment of ₹ 1,250 Million for a 7.69% stake, assigning Syngene a post money valuation of ₹16,250 Million o Investment earmarked for enhancing Syngene’s service offerings, capacities & fund future growth o GE brings in corporate best practices along with avenues for capability enhancement and new offerings 28 Revenues in ₹ Million 720 874 1,224 1,542 3,177 4,101 5,572 7,146 1,723 FY11 FY12 FY13 FY14 FY15 Q1
  • 30. Revenue 14,930 318 18,579 407 21,483 445 25,380 467 29,332 487 R&D Spend 785 17 1,183 26 1,366 28 1,640 30 1,310 22 EBITDA 4,551 97 5,733 125 5,791 120 5,957 110 7,429 123 Net profit* 2,729 58 3,399 74 3,384 70 3,241 60 4,137 69 EPS (FV: ₹ 5) 13.6 17.0 16.9 25.4 20.7 FY10 FY11 FY12 FY13 FY10-14: Avg.exch.rate in that fiscal ; Q1 FY14: USD 1 = ₹ 55.87; Q1 FY15: USD 1= ₹ 59.88 # Biopharmaceutical Sales including Branded Formulations |* Net Profit Pre exceptional items Financial Performance Q1 FY15 Q1 FY14 Revenue 7,420 | 124 7,234 | 129 R&D Spends 311 | 5 431 | 8 % of Biopharmaceutical Sales # 6% 8% EBITDA 1,907| 32 1,753| 31 EBITDA Margin 26% 24% Net Profit 1,030| 17 942| 17 PAT Margin 14% 13% EPS 5.2 4.7 All Figures in ₹ Millions /USD Mn except EPS FY14 30
  • 31. Core Business Margins: Detailed FY 10 FY 11 FY 12 FY 13 FY 14 Q1 FY15 Revenue 14,930 18,579 21,483 25,380 29,332 7,420 Less: Other Income 324 516 993 1,103 804 234 Less: Licensing Income 507 1,525 1,266 246 149 190 Core Revenues 14,099 16,538 19,224 24,031 28,379 6,996 EBITDA 4,551 5,733 5,791 5,957 7,429 1,907 Add: R&D Expense 785 1,183 1,366 1,640 1,310 311 Less: Other Income 324 516 993 1,103 804 234 Less: Licensing Income 507 1,525 1,266 246 149 190 Net EBITDA 4,505 4,875 4,899 6,248 7,786 1,794 Net EBITDA Margin 32% 29% 25% 26% 27% 26% 31
  • 32. India 39% Ex India 61% 12% 4,317 4,167 80 190 1,007 1,106 1,542 1,723 288 234 7,234 7,420 Q1 FY14 Q1 FY15 Revenue: Detailed 32 All Figures in ₹ Millions unless otherwise specified Core Biopharma Licensing Branded Formulations Research Services Other Income Geography Wise Sales Breakup: ₹ 7,186 (3)% 3% 10%
  • 34. o Small Molecules - Improved product Mix o Biosimilars - Geographical Expansion in semi regulated and regulated markets o Branded Formulations - Differentiated Value offerings o Research Services - Sustained Growth Momentum o Novel Molecules - Out-licensing and Global Development Growth drivers supplemented by addition of new offerings (products, services & partnerships) Key Focus Areas 34 Aspiring for $1 Billion in Revenues in 2018 Exchange Rate: 1 USD =₹ 50 30% 20% 20% 25% 5% 2018 E $1 Billion +
  • 35. ~61% | Promoters ~ 8 % | Employees & ESOP trust ~31 % | Public Biocon Business Structure & Holdings Syngene International, India | ~88% Custom research, drug discovery Clinigene International, India | 100% Clinical development Biocon Research , India | 100% R&D- Novel Molecules & Biosimilars Biocon Sdn. Bhd, Malaysia | 100% Overseas subsidiary Biocon SA, Switzerland | 100% Overseas subsidiary NeoBiocon, UAE | 50% Overseas subsidiary BIOPHARMA SUBSIDIARIES RESEARCH SERVICES Spanning the entire Value Chain with capabilities ranging from discovery to manufacturing 35
  • 36. 36 Saurabh Paliwal Tel : +91 80 2808 2808, Ext 2040 Tel Direct : +91 80 2808 2040 saurabh.paliwal@biocon.com Sweta Pachlangiya Tel : +91 80 2808 2808, Ext 5481 Tel Direct : +91 80 2808 5481 sweta.pachlangiya@syngeneintl.com Investor Contacts For updates and specific queries, please visit www.biocon.com or contact
  • 38. The Biologics Opportunity: Top Selling products 2013 # Drug Name Nature 2013 Sales 2009 Sales CAGR (%) 1 Humira MAb 11.0 5.6 19 2 Enbrel Recombinant product 8.8 6.5 8 3 Remicade MAb 8.4 5.9 9 4 Advair Small Molecules 8.3 8.0 1 5 Lantus Recombinant product 7.6 4.3 15 6 Rituxan MAb 7.5 5.6 7 7 Avastin MAb 6.8 5.7 4 8 Herceptin MAb 6.6 4.9 8 9 Januvia Small Molecule 6.2 1.9 34 10 Crestor Small Molecule 6.1 4.8 6 38 5/9 molecules in our biosimilar portfolio are part the global top-10 selling drugs list