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1. 1/15/2021 Could Cannabis Heighten a Protein's Ability to Fight Viruses and Inflammation?
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2. 1/15/2021 Could Cannabis Heighten a Protein's Ability to Fight Viruses and Inflammation?
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CANNABIS TO ENHANCE VIRUS FIGHTING
Could Cannabis Heighten a Protein's Ability
to Fight Viruses and In ammation?
ZBP1 is a unique protein that could be enhanced by cannabis in order to ght viruses
Posted by:
HighChi on Friday Jan 15, 2021
Could Cannabis Heighten a Protein’s Ability to Fight Viruses
and In ammation?

3. 1/15/2021 Could Cannabis Heighten a Protein's Ability to Fight Viruses and Inflammation?
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The year 2020 was largely dominated by the events of the COVID-19 pandemic. This has driven many cannabis
companies to make di erent claims about the e ectiveness of cannabis in helping to deal with viral infections. Cannabis
is already known to be a natural herb with numerous medicinal applications so it is important to know the true scope of
these claims. This article will shed light on the role of marijuana with viral infections and the possibility of cannabis
heightening a protein’s ability to ght viruses and in ammation.
Cannabis and in ammation
Cannabis has a very unique relationship with the immune system of the body. There are numerous components in the
full spectrum plant matrix of cannabis. CBD is one of the cannabinoids present in the matrix and research has shown
the relationship between CBD and the immune system. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828614/)By
indirectly acting through the endocannabinoid system, CBD helps to regulate the immune system. Through this activity
of regulating the immune system, CBD reduces the in ammatory response. This is the concept of the use of CBD for
dealing with muscle in ammation and other in ammatory diseases such as arthritis.
The immune system is very complex and plays host to di erent organs and cell types that help to ght foreign
molecules. The skin acts as a physical barrier to keep such foreign agents away but when they make their way into the
system, the immune system deals with them. When a virus makes its way into the body system, the immune system has

4. 1/15/2021 Could Cannabis Heighten a Protein's Ability to Fight Viruses and Inflammation?
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special antibodies that attack this viral agent. This special activity by the immune system and the special relationship
CBD has with the immune system has been purported for the anti-viral activity of cannabis. However, there are no
su cient studies yet to validate the antiviral activity of cannabis.
The body produces special endocannabinoids such as anandamide and 2-Arachidonyl Glycerol.
(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3997295/)The endocannabinoid system was initially thought to contain
two receptors majorly CB1 and CB2. However, research has shown that the system consists of over 50 enzymes,
receptors, and endocannabinoids. These endocannabinoids and the cannabinoids in cannabis work directly and
indirectly to a ect the immune system. This is the basis for the topical creams and transdermal patches used for pain
relief and to deal with in ammation.
Special protein that ghts viruses and proteins
Researchers in di erent centers are looking into the e ectiveness of a special protein with a unique ability to ght
viruses and in ammation. This special protein is known as ZBP1 and researchers from far and wide are already working
on it. Some of the top centers working on this protein include the Cluster of Excellence in Aging Research of the
University of Cologne, the University of Texas Health Science Center, and the Francis Crick Institute in London.
(https://www.crick.ac.uk/about-us/our-history/about-dr-francis-crick)
ZBP1 is a unique protein that has a special ability to defend against viruses. The protein is activated when it senses Z-
nucleic acids which is an unusual form of genetic material. The activation of this protein leads to the death of cells and
in ammation. Z-nucleic acid is a special cellular genetic material with double-stranded DAN and RBA molecules. It also
has a special left-handed double helix structure.
The protein has been discovered over 40 years ago and since then, scientists have been working to explore its potential.
The protein upon activation senses the genetic makeup of the virus and after identifying the threat, it activates a kill-
sequence. This is somewhat similar to the activity of some of the killer cells in the immune system against such foreign
invaders. The protein also activates this special kill-sequence when it senses RIPK1. RIPK1 is a special protein that stops
the activity of ZBP1.

5. 1/15/2021 Could Cannabis Heighten a Protein's Ability to Fight Viruses and Inflammation?
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This activity of ZBP1 also applies to the immune system and the regulation of in ammation. This is why it is also being
researched for in ammatory diseases such as arthritis. Di erent studies have been put forward to fully understand this
protein. Professor Manolis Pasparakis is one of the lead scientists in a study on ZBP1. Using mouse models to elicit the
action of the protein, it has been identi ed that the protein binds to double-stranded RNA. This binding action of the
protein helps it in the regulation of the immune system and in ammation.
Can cannabis heighten ZBP1?
The search into the complementary action of cannabis with ZBPI was birthed based on the similar
(https://www.drugabuse.gov/publications/research-reports/marijuana/how-does-marijuana-produce-its-e ects)ity in
their actions. The existence of such activity will help open up another mode of the e ectiveness of cannabis and CBD
against in ammation. It will also help to provide positive headway for alternative therapies for dealing with
in ammatory diseases such as arthritis.
With the similarities in their activities, some studies are con dently looking into the use of cannabis to heighten the
activity of ZBP1. In vivo and in vitro studies already show the activity of CBD in the regulation of the immune system.
Scientists are looking into the possibility of this activity of CBD contributing to that of ZBP1. It will serve as the basis for
novel therapies for diseases involving viral infections and in ammation.
Although, it is still very early to say, early signs point to the e ectiveness of cannabis to heighten ZBP1. Both have
similar e ects, chances are that the use of cannabis will o er synergistic action. Scientists are already looking into ways
to solidify the e ects of THC on the body and its genomes. This protein o ers a chance to fully study that and o er a
new therapy model heading into the future.
Bottom line
The uniqueness of ZBP1 and its activity makes it a gem in the medical world. It is not a matter of IF but a matter of
WHEN scientists utilize it for the betterment of health. With a combination of cannabis and the bene cial cannabinoids,
ZBP1 can be a huge bene t in the ght against viruses and in ammatory diseases. Although there is still a need for
more clinical researches to be carried out on the protein; early indications show promise which is why scientists are
pressing on.

6. 1/15/2021 Could Cannabis Heighten a Protein's Ability to Fight Viruses and Inflammation?
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VIRUS FIGHTING WEED, READ MORE..
(https://cannabis.net/blog/opinion/do-the-antiviral-properties-of-
cannabis-translate-to-the-coronavirus-covid19)
CAN CANNABIS HELP FIGHT THE BODY FIGHT COVID-19? (https://cannabis.net/blog/opinion/do-the-antiviral-
properties-of-cannabis-translate-to-the-coronavirus-covid19)
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of your actions and emotions. It is the main reason why you feel distressed, annoyed, and uncomfortable with your surroundings. But with the help of the aroma
of essential oils, you will be able to let your brain relax and give your mind a positive response, relieving your body from stress and tension.
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