2. DISEASE Occurrence of Disease

4. Wild Animals Involved in MPXV Transmission (USA, 2003) Gambian Giant Rat (Crycetomys sp.) Prairie Dog (Cynomis sp.)

5. Ghana TX WI IL * IA 15/4 09/04 Entry and Distribution Route of Crycetomys sp . and Cynomys sp. Involved in MPXV Outbreak (USA, 2003) Source: MMWR 52 (23), CDC, 2003. 15/4

6. Index case in Marshfield, 26 May 2003: Disseminated lesions.

7. Distribution of MPXV Cases in the USA WI IL IN OH KS MO Number of cases = 87 WI = 38 IN = 24 IL = 19 OH = 4 KS = 1 MO = 1 Source: MMWR 52 (23), CDC, 2003.

27. Antigen Presentation

37. 2005 - Rubella declared no longer endemic in the US

42. Whole Cell Vaccines

45. Acellular Vaccines

52. Vibrionaceae

53. Vibrio – isolated in 1884

64. Transmission

69. Cholera Cot – Cholera Facies

80. Tetanus cases reported worldwide 1990-2004. Ranging from strongly prevalent (dark red) to very few cases (in light yellow) (grey data).

81. Tetanus

93. Diptheria

98. Capsules

115. Haemophilus influenzae B

116. Act-HIB Haemophilus influenzae type b (Hib) Act-HIB ® (Haemophilus b conjugate vaccine, tetanus protein - conjugate) 01959034 5 x 0.5 mL

117. Haemophilus influenzae produces beta-lactamases, and it is also able to modify iHaemophilus influenzae produces beta-lactamases, and it is also able to modify its penicillin-binding proteins, so it has gained resistance to the penicillin family of antibiotics.

118. In severe cases, cefotaxime and ceftriaxone delivered directly into the bloodstream are the elected antibiotics, and, for the less severe cases, an association of ampicillin and sulbactam, cephalosporins of the second and thirdgeneration, or fluoroquinolones are preferred. (Fluoroquinolone-resistant Haemophilus influenzae has been observed.)