Active constituent of Turmeric as Anticancer

1. Active constituent of Curcuma
longa Linn (Turmeric) Used as
Antitumor

2. Synonyms
Saffron Indian; Haldi ; Curcuma; Rhizoma
curcumae.
Biological Source
Turmeric is the dried rhizome of Curcuma
longa Linn. belonging to family
Zingiberaceae.
Geographical Source
The plant is a native to southern Asia and is
cultivated extensively in temperate regions.
It is grown on a larger scale in India, China,
East Indies and Pakistan.

3. Extraction
1. Pieces of
dried
rhizomes
2. Transferred
into glass bottle
3. Gradually shaken
to mix the material
4. Placed in
dark at Room
Temperature
5. Extract fiter by muslin
cloth followed by
whatmann filter paper
6. Clear solution
collect in amber
reagent bottle
Add Ethanol
100%
Solvent Extraction Method :

4. ChemicalConstituents • Curcumin, demethoxycurcumin (DMC),
bisdemethoxycurcumin (BDMC)
• Eugenol, dihydrocurcumin, azulene, borneol,
d-camphene, caprylic acid, cineol, turmerone.

6. • Chemically it is 1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione
or diferuloylmethane
• It is a member of the diarylheptanoid
• This class is comprised of two aromatic rings linked by 1,6-heptadiene-3,5-
dione moiety
• Curcumin exists in multiple tautomeric states in which the diketone is stable in
the enol state while being easily deprotonated to the keto state
Curcumin

7. Chemical structures of keto and enol forms of curcumin

8. MedicinalActivity
 Antitumor activity
 Antioxidant activity
 Antidiabetic activity
 Hepatoprotective activity
 Antialzhiemer activity
 Anti-HIV activity
 Antivenom activity
 Anti-inflammatory activity
 Antibacterial activity
 Digestive Agent

9. Mechanism of Action
 Inhibition of constitutively activated targets of PI3'-kinase
(AKT,FOXOandGSK3) in T-cell acute lymphoblastic leukemia cells,
leading to the inhibition of proliferation and induction of caspase-
dependent apoptosis
 Inhibition of MDM2 oncogen through the transcription factor ETS2
by modulation of the PI3K/mTOR signaling pathway.
 Induction of an increase in the protein levels of the pro apoptotic
Bcl-2 family members Bax and Bak, which was essential for
maximum apoptotic activity

10. Structure Activity Relationship

11. Synthesis