This ppt is a lengthy overview of what goes in to creating pdfs, and what sometimes makes them difficult for printing. There is some good information on how to create high quality pdfs that are up to ISO standards.
51. For making PDFs to print c onsider using a standard like ISO PDF/X-3:2002
52. PDF /X-3:2002 - doesn’t allow trans parencies - fonts must be embedded - pdf version is set to 1.3 - properly configures color - resolves any pagebox issues