O slideshow foi denunciado.
Utilizamos seu perfil e dados de atividades no LinkedIn para personalizar e exibir anúncios mais relevantes. Altere suas preferências de anúncios quando desejar.

Eventos Adversos

53.843 visualizações

Publicada em

  • DOWNLOAD THE BOOK INTO AVAILABLE FORMAT (New Update) ......................................................................................................................... ......................................................................................................................... Download Full PDF EBOOK here { https://urlzs.com/UABbn } ......................................................................................................................... Download Full EPUB Ebook here { https://urlzs.com/UABbn } ......................................................................................................................... Download Full doc Ebook here { https://urlzs.com/UABbn } ......................................................................................................................... Download PDF EBOOK here { https://urlzs.com/UABbn } ......................................................................................................................... Download EPUB Ebook here { https://urlzs.com/UABbn } ......................................................................................................................... Download doc Ebook here { https://urlzs.com/UABbn } ......................................................................................................................... ......................................................................................................................... ................................................................................................................................... eBook is an electronic version of a traditional print book THE can be read by using a personal computer or by using an eBook reader. (An eBook reader can be a software application for use on a computer such as Microsoft's free Reader application, or a book-sized computer THE is used solely as a reading device such as Nuvomedia's Rocket eBook.) Users can purchase an eBook on diskette or CD, but the most popular method of getting an eBook is to purchase a downloadable file of the eBook (or other reading material) from a Web site (such as Barnes and Noble) to be read from the user's computer or reading device. Generally, an eBook can be downloaded in five minutes or less ......................................................................................................................... .............. Browse by Genre Available eBOOK .............................................................................................................................. Art, Biography, Business, Chick Lit, Children's, Christian, Classics, Comics, Contemporary, CookBOOK, Manga, Memoir, Music, Mystery, Non Fiction, Paranormal, Philosophy, Poetry, Psychology, Religion, Romance, Science, Science Fiction, Self Help, Suspense, Spirituality, Sports, Thriller, Travel, Young Adult, Crime, EBOOK, Fantasy, Fiction, Graphic Novels, Historical Fiction, History, Horror, Humor And Comedy, ......................................................................................................................... ......................................................................................................................... .....BEST SELLER FOR EBOOK RECOMMEND............................................................. ......................................................................................................................... Blowout: Corrupted Democracy, Rogue State Russia, and the Richest, Most Destructive Industry on Earth,-- The Ride of a Lifetime: Lessons Learned from 15 Years as CEO of the Walt Disney Company,-- Call Sign Chaos: Learning to Lead,-- StrengthsFinder 2.0,-- Stillness Is the Key,-- She Said: Breaking the Sexual Harassment Story THE Helped Ignite a Movement,-- Atomic Habits: An Easy & Proven Way to Build Good Habits & Break Bad Ones,-- Everything Is Figureoutable,-- What It Takes: Lessons in the Pursuit of Excellence,-- Rich Dad Poor Dad: What the Rich Teach Their Kids About Money THE the Poor and Middle Class Do Not!,-- The Total Money Makeover: Classic Edition: A Proven Plan for Financial Fitness,-- Shut Up and Listen!: Hard Business Truths THE Will Help You Succeed, ......................................................................................................................... .........................................................................................................................
       Responder 
    Tem certeza que deseja  Sim  Não
    Insira sua mensagem aqui
  • DOWNLOAD THE BOOK INTO AVAILABLE FORMAT (New Update) ......................................................................................................................... ......................................................................................................................... Download Full PDF EBOOK here { https://urlzs.com/UABbn } ......................................................................................................................... Download Full EPUB Ebook here { https://urlzs.com/UABbn } ......................................................................................................................... Download Full doc Ebook here { https://urlzs.com/UABbn } ......................................................................................................................... Download PDF EBOOK here { https://urlzs.com/UABbn } ......................................................................................................................... Download EPUB Ebook here { https://urlzs.com/UABbn } ......................................................................................................................... Download doc Ebook here { https://urlzs.com/UABbn } ......................................................................................................................... ......................................................................................................................... ................................................................................................................................... eBook is an electronic version of a traditional print book THE can be read by using a personal computer or by using an eBook reader. (An eBook reader can be a software application for use on a computer such as Microsoft's free Reader application, or a book-sized computer THE is used solely as a reading device such as Nuvomedia's Rocket eBook.) Users can purchase an eBook on diskette or CD, but the most popular method of getting an eBook is to purchase a downloadable file of the eBook (or other reading material) from a Web site (such as Barnes and Noble) to be read from the user's computer or reading device. Generally, an eBook can be downloaded in five minutes or less ......................................................................................................................... .............. Browse by Genre Available eBOOK .............................................................................................................................. Art, Biography, Business, Chick Lit, Children's, Christian, Classics, Comics, Contemporary, CookBOOK, Manga, Memoir, Music, Mystery, Non Fiction, Paranormal, Philosophy, Poetry, Psychology, Religion, Romance, Science, Science Fiction, Self Help, Suspense, Spirituality, Sports, Thriller, Travel, Young Adult, Crime, EBOOK, Fantasy, Fiction, Graphic Novels, Historical Fiction, History, Horror, Humor And Comedy, ......................................................................................................................... ......................................................................................................................... .....BEST SELLER FOR EBOOK RECOMMEND............................................................. ......................................................................................................................... Blowout: Corrupted Democracy, Rogue State Russia, and the Richest, Most Destructive Industry on Earth,-- The Ride of a Lifetime: Lessons Learned from 15 Years as CEO of the Walt Disney Company,-- Call Sign Chaos: Learning to Lead,-- StrengthsFinder 2.0,-- Stillness Is the Key,-- She Said: Breaking the Sexual Harassment Story THE Helped Ignite a Movement,-- Atomic Habits: An Easy & Proven Way to Build Good Habits & Break Bad Ones,-- Everything Is Figureoutable,-- What It Takes: Lessons in the Pursuit of Excellence,-- Rich Dad Poor Dad: What the Rich Teach Their Kids About Money THE the Poor and Middle Class Do Not!,-- The Total Money Makeover: Classic Edition: A Proven Plan for Financial Fitness,-- Shut Up and Listen!: Hard Business Truths THE Will Help You Succeed, ......................................................................................................................... .........................................................................................................................
       Responder 
    Tem certeza que deseja  Sim  Não
    Insira sua mensagem aqui
  • DOWNLOAD THE BOOK INTO AVAILABLE FORMAT (New Update) ......................................................................................................................... ......................................................................................................................... Download Full PDF EBOOK here { https://soo.gd/irt2 } ......................................................................................................................... Download Full EPUB Ebook here { https://soo.gd/irt2 } ......................................................................................................................... Download Full doc Ebook here { https://soo.gd/irt2 } ......................................................................................................................... Download PDF EBOOK here { https://soo.gd/irt2 } ......................................................................................................................... Download EPUB Ebook here { https://soo.gd/irt2 } ......................................................................................................................... Download doc Ebook here { https://soo.gd/irt2 } ......................................................................................................................... ......................................................................................................................... ................................................................................................................................... eBook is an electronic version of a traditional print book THE can be read by using a personal computer or by using an eBook reader. (An eBook reader can be a software application for use on a computer such as Microsoft's free Reader application, or a book-sized computer THE is used solely as a reading device such as Nuvomedia's Rocket eBook.) Users can purchase an eBook on diskette or CD, but the most popular method of getting an eBook is to purchase a downloadable file of the eBook (or other reading material) from a Web site (such as Barnes and Noble) to be read from the user's computer or reading device. Generally, an eBook can be downloaded in five minutes or less ......................................................................................................................... .............. Browse by Genre Available eBOOK .............................................................................................................................. Art, Biography, Business, Chick Lit, Children's, Christian, Classics, Comics, Contemporary, CookBOOK, Manga, Memoir, Music, Mystery, Non Fiction, Paranormal, Philosophy, Poetry, Psychology, Religion, Romance, Science, Science Fiction, Self Help, Suspense, Spirituality, Sports, Thriller, Travel, Young Adult, Crime, EBOOK, Fantasy, Fiction, Graphic Novels, Historical Fiction, History, Horror, Humor And Comedy, ......................................................................................................................... ......................................................................................................................... .....BEST SELLER FOR EBOOK RECOMMEND............................................................. ......................................................................................................................... Blowout: Corrupted Democracy, Rogue State Russia, and the Richest, Most Destructive Industry on Earth,-- The Ride of a Lifetime: Lessons Learned from 15 Years as CEO of the Walt Disney Company,-- Call Sign Chaos: Learning to Lead,-- StrengthsFinder 2.0,-- Stillness Is the Key,-- She Said: Breaking the Sexual Harassment Story THE Helped Ignite a Movement,-- Atomic Habits: An Easy & Proven Way to Build Good Habits & Break Bad Ones,-- Everything Is Figureoutable,-- What It Takes: Lessons in the Pursuit of Excellence,-- Rich Dad Poor Dad: What the Rich Teach Their Kids About Money THE the Poor and Middle Class Do Not!,-- The Total Money Makeover: Classic Edition: A Proven Plan for Financial Fitness,-- Shut Up and Listen!: Hard Business Truths THE Will Help You Succeed, ......................................................................................................................... .........................................................................................................................
       Responder 
    Tem certeza que deseja  Sim  Não
    Insira sua mensagem aqui
  • DOWNLOAD THE BOOK INTO AVAILABLE FORMAT (New Update) ......................................................................................................................... ......................................................................................................................... Download Full PDF EBOOK here { https://soo.gd/irt2 } ......................................................................................................................... Download Full EPUB Ebook here { https://soo.gd/irt2 } ......................................................................................................................... Download Full doc Ebook here { https://soo.gd/irt2 } ......................................................................................................................... Download PDF EBOOK here { https://soo.gd/irt2 } ......................................................................................................................... Download EPUB Ebook here { https://soo.gd/irt2 } ......................................................................................................................... Download doc Ebook here { https://soo.gd/irt2 } ......................................................................................................................... ......................................................................................................................... ................................................................................................................................... eBook is an electronic version of a traditional print book THE can be read by using a personal computer or by using an eBook reader. (An eBook reader can be a software application for use on a computer such as Microsoft's free Reader application, or a book-sized computer THE is used solely as a reading device such as Nuvomedia's Rocket eBook.) Users can purchase an eBook on diskette or CD, but the most popular method of getting an eBook is to purchase a downloadable file of the eBook (or other reading material) from a Web site (such as Barnes and Noble) to be read from the user's computer or reading device. Generally, an eBook can be downloaded in five minutes or less ......................................................................................................................... .............. Browse by Genre Available eBOOK .............................................................................................................................. Art, Biography, Business, Chick Lit, Children's, Christian, Classics, Comics, Contemporary, CookBOOK, Manga, Memoir, Music, Mystery, Non Fiction, Paranormal, Philosophy, Poetry, Psychology, Religion, Romance, Science, Science Fiction, Self Help, Suspense, Spirituality, Sports, Thriller, Travel, Young Adult, Crime, EBOOK, Fantasy, Fiction, Graphic Novels, Historical Fiction, History, Horror, Humor And Comedy, ......................................................................................................................... ......................................................................................................................... .....BEST SELLER FOR EBOOK RECOMMEND............................................................. ......................................................................................................................... Blowout: Corrupted Democracy, Rogue State Russia, and the Richest, Most Destructive Industry on Earth,-- The Ride of a Lifetime: Lessons Learned from 15 Years as CEO of the Walt Disney Company,-- Call Sign Chaos: Learning to Lead,-- StrengthsFinder 2.0,-- Stillness Is the Key,-- She Said: Breaking the Sexual Harassment Story THE Helped Ignite a Movement,-- Atomic Habits: An Easy & Proven Way to Build Good Habits & Break Bad Ones,-- Everything Is Figureoutable,-- What It Takes: Lessons in the Pursuit of Excellence,-- Rich Dad Poor Dad: What the Rich Teach Their Kids About Money THE the Poor and Middle Class Do Not!,-- The Total Money Makeover: Classic Edition: A Proven Plan for Financial Fitness,-- Shut Up and Listen!: Hard Business Truths THE Will Help You Succeed, ......................................................................................................................... .........................................................................................................................
       Responder 
    Tem certeza que deseja  Sim  Não
    Insira sua mensagem aqui
  • DOWNLOAD THE BOOK INTO AVAILABLE FORMAT (New Update) ......................................................................................................................... ......................................................................................................................... Download Full PDF EBOOK here { https://soo.gd/irt2 } ......................................................................................................................... Download Full EPUB Ebook here { https://soo.gd/irt2 } ......................................................................................................................... Download Full doc Ebook here { https://soo.gd/irt2 } ......................................................................................................................... Download PDF EBOOK here { https://soo.gd/irt2 } ......................................................................................................................... Download EPUB Ebook here { https://soo.gd/irt2 } ......................................................................................................................... Download doc Ebook here { https://soo.gd/irt2 } ......................................................................................................................... ......................................................................................................................... ................................................................................................................................... eBook is an electronic version of a traditional print book THE can be read by using a personal computer or by using an eBook reader. (An eBook reader can be a software application for use on a computer such as Microsoft's free Reader application, or a book-sized computer THE is used solely as a reading device such as Nuvomedia's Rocket eBook.) Users can purchase an eBook on diskette or CD, but the most popular method of getting an eBook is to purchase a downloadable file of the eBook (or other reading material) from a Web site (such as Barnes and Noble) to be read from the user's computer or reading device. Generally, an eBook can be downloaded in five minutes or less ......................................................................................................................... .............. Browse by Genre Available eBOOK .............................................................................................................................. Art, Biography, Business, Chick Lit, Children's, Christian, Classics, Comics, Contemporary, CookBOOK, Manga, Memoir, Music, Mystery, Non Fiction, Paranormal, Philosophy, Poetry, Psychology, Religion, Romance, Science, Science Fiction, Self Help, Suspense, Spirituality, Sports, Thriller, Travel, Young Adult, Crime, EBOOK, Fantasy, Fiction, Graphic Novels, Historical Fiction, History, Horror, Humor And Comedy, ......................................................................................................................... ......................................................................................................................... .....BEST SELLER FOR EBOOK RECOMMEND............................................................. ......................................................................................................................... Blowout: Corrupted Democracy, Rogue State Russia, and the Richest, Most Destructive Industry on Earth,-- The Ride of a Lifetime: Lessons Learned from 15 Years as CEO of the Walt Disney Company,-- Call Sign Chaos: Learning to Lead,-- StrengthsFinder 2.0,-- Stillness Is the Key,-- She Said: Breaking the Sexual Harassment Story THE Helped Ignite a Movement,-- Atomic Habits: An Easy & Proven Way to Build Good Habits & Break Bad Ones,-- Everything Is Figureoutable,-- What It Takes: Lessons in the Pursuit of Excellence,-- Rich Dad Poor Dad: What the Rich Teach Their Kids About Money THE the Poor and Middle Class Do Not!,-- The Total Money Makeover: Classic Edition: A Proven Plan for Financial Fitness,-- Shut Up and Listen!: Hard Business Truths THE Will Help You Succeed, ......................................................................................................................... .........................................................................................................................
       Responder 
    Tem certeza que deseja  Sim  Não
    Insira sua mensagem aqui

Eventos Adversos

  1. 1. EVENTOS ADVERSOS REACCIONES ADVERSAS DR. ALFONSO VALENCIA EPIDEMIOLOGIA UNIVERSIDAD EL BOSQUE
  2. 4. EVENTOS ADVERSOS <ul><li>LOS EVENTOS ADVERSOS SE DEFINEN SIGNOS Y SINTOMAS FISICOS Y PSICOLOGICOS QUE PUEDEN O NO RELACIONARSE CON EL ENSAYO DE UNA MEDICINA </li></ul><ul><li>LAS REACCIONES ADVERSAS SON UN MOMENTO DONDE EXISTE UNA RELACION </li></ul>
  3. 5. EVENTOS ADVERSOS <ul><li>L AS REACIONES ADVERSAS PUEDEN SER DEBIDOS A LA TOXICIDAD INTRENSECA DEL MEDICAMENTO O SER IDIOSINCRATICOS. SI ESTAN RELACIONADOS CON LA TOXICIDAD INTRINSECA, LAS REACCIONES ADVERSAS SE PRESENTAN DE MANERA TEMPRANA DURANTE EL DESARROLLO DE LOS FARMACOS </li></ul>
  4. 6. <ul><li>SE PUEDEN CLASIFICAR EN CINCO TIPOS </li></ul><ul><ul><li>RESULTADO DE UNA DOSIS EXCESIVA </li></ul></ul><ul><ul><li>RESULTADO DE UN EFECTO EXCESIVO </li></ul></ul><ul><ul><li>RESULTADO DE INTERACION CON OTRAS MEDICINAS U OTROS FACTORES </li></ul></ul><ul><ul><li>EFECTOS IDIOSINCRATICOS </li></ul></ul><ul><ul><li>DE ADMINISTRACION O SUGESTION </li></ul></ul>
  5. 7. <ul><li>LAS EXPERIENCIAS ADVERSAS SE DEFINIEN COMO UN GRUPO DE REACCIONES ADVERSAS MAS TODOS LOS EVENTOS MEDICOS QUE PUEDAN OCURRIRDURANTE EL ENSAYO </li></ul>
  6. 8. <ul><li>S E DEBEN REALIZAR DEFINICIONES OPERACIONALES DE LOS EFECTOS ESPERADOS ANTES DEL INICIO DEL ENSAYO CLINICO, ESTO PERMITE CLARIFICAR LAS DIFERENCIAS EN DEFINICION PARA REACIIONES ADVERSAS QUE PUDIERAN SON SIMILARES EN NATURALEZA. </li></ul>
  7. 10. INTENSIDAD DE LA REACCION <ul><li>LEVE: LA REACCION NO INTERFIERE CON EL FUNCIONAMIENTO NORMAL DEL SUJETO </li></ul><ul><li>MODERADO: LA REACION PRODUCE ALGUN GRADO DE LIMITACION FUNCIONALPERO NO ES PELIGROSO PARA LA VIDA </li></ul><ul><li>SEVERO: LA REACCION PRODUCE LIMITACION FUNCIONAL O INCAPACIDAD SIGNIFICATIVA Y COSNDTITUYE UN PELIGRO PARA LA SALUD DEL SUJETO </li></ul>
  8. 11. <ul><li>ESTAS CATEGORIAS SE BASAN EN EL JUICIO CLINICO DEL INVESTIGADOR </li></ul>
  9. 12. CATEGORIZACION <ul><li>DEFINITIVA: AQUELLA QUE SIGUE UNA SECUENCIA TEMPORAL RAZONABLE DESDE LA ADMISTRACION DEL FARMACO EN LA CUAL LOS NIVELES DE MEDICAMENTO SE HAN ESTABLECIDO EN LIQUIDOS CORPORALES O TEJIDOS; ESTA SIGUE UN PATRON DE RESPUESTA CONOCIDO O ESPERADO PARA ESA MEDICINA; ESTO ES CONFIRMADO POR LA MEJORIA AL RETIRAR O DISMINUIR LA DOSIS. </li></ul>
  10. 14. <ul><li>PROBABLE: AQUELLA QUE SIGUE UNA SECUENCIA TEMPORAL RAZONABLE DESDE LA ADMISTRACION DEL FARMACO; ESTA SIGUE UN PATRON DE RESPUESTA CONOCIDO O ESPERADO PARA ESA MEDICINA; ESTO ES CONFIRMADO POR LA MEJORIA AL RETIRAR O DISMINUIR LA DOSIS, Y QUE NO PUEDE EXPLICADA RAZONABLEMENTE POR LAS CARACTERISTICAS DEL ESTADO CLINICO DEL PACIENTE </li></ul>
  11. 15. <ul><li>POSIBLE: AQUELLA QUE SIGUE UNA SECUENCIA TEMPORAL RAZONABLE DESDE LA ADMISTRACION DEL FARMACO; ESTA SIGUE UN PATRON DE RESPUESTA CONOCIDO O ESPERADO PARA ESA MEDICINA; PERO QUE PODRIA SER PRODUCIDA POR OTROS FACTORES </li></ul>
  12. 16. <ul><li>DESCONOCIDA: DONDE O SE PUEDE ESTABLECER UNA EVALUACION NI RELACION </li></ul><ul><li>NO RELACIONADA: UNA REACCION PARA LA CUAL EXISTE SUFICIENTE INFORMACION QUE INDICA QUE LA ETIOLOGIA NO ESTA RELACIONADA CON LA MEDICINA EN ENSAYO </li></ul>
  13. 18. INTERPRETACION DE LAS REACIONES ADVERSAS
  14. 19. <ul><li>NIVELES DE REACCIONES ADVERSAS </li></ul><ul><ul><li>UN SOLO PACIENTE </li></ul></ul><ul><ul><li>UN ENSAYO CLINICO AISLADO </li></ul></ul><ul><ul><li>MULTIPLES ENSAYOS EN UNA SOLA MEDICACION </li></ul></ul>
  15. 20. <ul><li>DEFINICION OPERACIONAL Y CLASIFICACION DE LA REACION DE MANERA INDIVIDUAL </li></ul><ul><li>TIPOS DE TOXICIDAD </li></ul><ul><li>INDICE TERAPEUTICO </li></ul><ul><li>RECOLECCION Y MONITOREO DE REACCIONES ADVERSAS </li></ul><ul><li>PROBABILIDAD DE APARICION DE UNA REACCION ADVERSA </li></ul><ul><li>MEDIDA DE LA REACCION ADVERSA Y DETERMINACION DE SU SIGNIFICANCIA CLINICA </li></ul><ul><li>ASOCIACION DE UNA REACION ADVERSA A UN MEDICAMENTO O TRATAMIENTO EN PARTICULAR </li></ul><ul><li>CLASIFICACION DE LA ASOCIACION ENTRE REACCIONES ADVERSAS Y ENSAYO O EVENTOS NO MEDICOS </li></ul><ul><li>MEJORAR LA CONFIANZA ENTRE E INTRA TASAS DE REACIONES ADVERSAS </li></ul><ul><li>COMO UNA REACION ADVERSA PUEDE RELACIONARSE CON EL DISEÑO DEL ENSAYO CLINICO O SU CONDUCION </li></ul><ul><li>COMO TRATAR REACIONES ADVERSAS </li></ul><ul><li>INFLUENCIA DE MEDICINAS CONCOMITANTES O LA LINES DE BASE EN LAS REACIONES ADVERSAS </li></ul><ul><li>IMPACTO DE LAS REACCIONES ADVERSAS DE UN ENSAYO EN OTROS DESARROLLADOS CON LA MISMA MEDICINA </li></ul><ul><li>OBTENCION DE INFORMACION DE UNA REACION ADVERSA DURANTE UN ENSAYO </li></ul><ul><li>CUALES SON LAS IMPLICACIONES SA POCAS O NINGUNA REACION SE REPORTAN </li></ul><ul><li>CUALES SON LAS IMPLICACIONES SI SON DEMASIADAS O SOLAMENTE REACIONES SEVERAS LAS REPORTADAS </li></ul>
  16. 21. <ul><ul><li>TIPOS DE TOXICIDAD </li></ul></ul><ul><ul><li>TIPO I: RESULTADO DE UN EXCESO DEL EFECTO FARMACOLOGICO </li></ul></ul><ul><ul><li>TIPO II: RESULTADO DE UN EFECTO NO FARMACOLÓGICO </li></ul></ul><ul><ul><li>TIPO III: RESULTADOS POR EFECTOS NO OBSERVADOS A DOSIS TERAPEUTICAS </li></ul></ul><ul><ul><li>TIPO IV: EFECTOS IDIOSINCRATICOS OCURREN EN TASAS EXTREMADAMENTE BAJAS </li></ul></ul>
  17. 23. <ul><li>REACCIONES ADVERSAS ENTRE MEDICAMENTOS INNOVADORES Vs GENERICOS </li></ul><ul><li>REPORTE DE REACIONES ADVERSAS POR REPRESENTANTES DE VENTAS </li></ul><ul><li>COMO SE DEBEN CARACTERIZAR COMO PARTE DE UN PROCEDIMIENTO MEDICO O QUIRURGICO </li></ul><ul><li>TIEMPO DE OCURRENCIA DEL EVENTO EN RELACIONA LA ADMINISTRACION DE LA MEDICINA </li></ul><ul><li>ANALISIS ESTADISTICO DE LAS REACCIONES ADVERSAS </li></ul><ul><li>PROCESO PARA DETERMINAR LA SIGNIFICANCIA CLINICA DE LAS REACCIONES ADVERSAS </li></ul><ul><li>SIGNIFICANCIA CLINICA DE LAS REACCIONES ADVERSAS </li></ul><ul><li>DESCUBRIMIENTO DE NUEVAS INDICACIONES BASADAS EN REACCIONES ADVERSAS </li></ul><ul><li>PRESENTACIONDE DATOS SUFICIENTES SOBRE LAS REACCIONES </li></ul><ul><li>CAMBIO EN LAS REACCIONES ATRAVES DEL TIEMPO </li></ul><ul><li>FORMACION DE HIPOTESIS ACERCA DE LAS REACCIONES ADVERSAS </li></ul><ul><li>VIGILANCIA POST MARKETING DE LAS REACCIONES </li></ul><ul><li>SEGUIMIENTO DEL PATRON DE UNA REACCION ADVERSA DURANTE LA VIDAD DE UN MEDICAMENTO </li></ul><ul><li>METODOS PARA DISMIUIR LA INCIDENCIA O MINIMIZAR LA SEVERIDAD DE LAS REACCIONES </li></ul><ul><li>ALCANZAR UNA IMPRESIÓN GENERAL DE LA SIGNIFICANCIA CLINICA DE LAS REACCIONES ADVERSAS </li></ul><ul><li>PERFIL DE LAS REACIONES ADVERSAS DE UNA MEDICACION DURANTE SU INVESTIGACION INICIAL Vs LE PERIODO DE MERCADEO </li></ul><ul><li>PLANEAR ENSAYOS CLINICOS FUTUROS PARA EVALUAR REACCIONES ADVERSAS </li></ul>
  18. 25. ANALISIS CLINICO DE LOS DATOS <ul><li>USO DE INFORMACION DE LABORATORIO </li></ul><ul><ul><li>SCRENING DE RUTINA </li></ul></ul><ul><ul><li>EVALUACION DIAGNOSTICA DEL PACIENTE </li></ul></ul><ul><ul><li>IDENTIFICACION DE FACTORES DE RIESGO </li></ul></ul><ul><ul><li>DETECION DE REACIONES ADVERSAS </li></ul></ul><ul><ul><li>DETERMINACION DE DOSIS APROPIADA DE MEDICAMENTOS </li></ul></ul><ul><ul><li>ASEGURAR NIVELES TERAPEUTICOS ADECUADOS </li></ul></ul><ul><ul><li>CONFIRMAR RESULTADOS INESPERADOS </li></ul></ul>
  19. 27. <ul><li>VALORES DE REFERENCIA </li></ul><ul><li>SE REFIEREN AL VALOR PROMEDIO Y DOS DESVIACIONES ESTANDAR A CADA LADO DEL PROMEDIO </li></ul>
  20. 29. FACTORES QUE AFECTAN LA INTERPRETACION DE RESULTADOS DE LABORATORIO <ul><li>VALORES PRESENTES </li></ul><ul><li>VALORES PREVIOS </li></ul><ul><li>LINEAS DE BASE </li></ul><ul><li>TENDENCIAS </li></ul><ul><li>VALIDES </li></ul><ul><li>NIVELES DE DECISION </li></ul><ul><li>POBLACION DE REFERENCIA </li></ul><ul><li>HISTORIA MEDICA </li></ul><ul><li>DURACION DEL TRATAMIENTO </li></ul><ul><li>PROPOSITO </li></ul><ul><li>TAMAÑO DE LA ANORMALIDAD </li></ul><ul><li>TRATAMIENTOS Y MEDICAMENTOS CONCOMITANTES </li></ul><ul><li>ENFERMEDADES PRESENTES </li></ul><ul><li>ERRORES DE LABORATORIOPROGRESION DE LA ENFERMEDAD </li></ul><ul><li>PATRONES DE OCURRENCIA Y ANORMALIDAD </li></ul><ul><li>OTRAS ANORMALIDADES </li></ul><ul><li>FUENTES DE INFORMACION </li></ul>

×