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AORTIC
DISEASES
Dr Mohammad
Ali Khalid
 VALVE

 VESSEL

 Stenosis

 Dissection

(AS)
 Regurgitation (AR)
 Mixed(AS+AR)

 Anuerysm
Aortic stenosis
 Normal

valve area 2.4-5.5cm2
 Normal pressure gradient across valve
upto 11 mm hg
 Normal cusp seperation 15-25mm
Essentials of diagnosis










Chest pain
Dysponea
Effort syncope
Arrythmias(tachycardias,VPC‟s,VT,AF)
Pulse parvus et tardus
Heaving apex beat
Ejection systolic murmer left upper sternal
edge radiating to carotids
Thrill?
Severe AS
 Late

peaking murmer
 Fourth heart sound
 Thrill
 Reverse split
General considerations
 Narrowing

of aortic valve leaflets
 Calcification
 Impedence to blood flow
 Increased LV workload
 Relative blood supply insufficiency-Angina
 Finally LVF
 Exertional syncope
 Sudden death
Causes
 Bicuspid

aortic valve(young)
 Degenerative(elderly)
 Rhuematic
 SLE,hyperlidaemia,oochronosis(rare)
SYMPTOMS &SIGNS
 Palpitations

especially on effort
 Angina
 Syncopal attacks
 Breathlessness
 Frank CCF

 charecteristic
 Heaving

pulse

apex

 Murmer
 Fourth

heart sound

 Thrill
 Reverse

split
Aortic Stenosis: Physical Findings

S1

S2

S1

S2
Investigations
 ECG-LVH,Ischaemia,AF,other
 CXR-increased

changes

CTR,CCF
 Echo-valve area,flow rate,cusp
seperation,gradient,LV dimensions
 Cardiac catheterization
Cath studies
 SEVERITY

GRADIENT
 Mild
<25
 Moderate
26-50
 Severe
>50
 Critical
>80

AVA(cm2)
>1.5
1.0-1.5
<1.0
<0.7
Treatment
 Pharmacological(symptomatic/palliative)
 Surgical(definitive)
Medical management






Antibiotic prophylaxis for endocarditis
Treat AF vigorously-amiodarone
Avoid;
CCB
ACEI/ARB‟S
Digoxin
Nitrates
Betablockers cautiously.
Surgical
 Aortic





balloon valvuloplasty
Congenital AS
Palliation in elderly
Bridge to AVR in critically ill
50% restenosis in six months
Rule of „Five‟
 LVEDD>55mm
 EF<55%
 Gradient>50mm

Hg
Surgery
 Heart

failure
 Syncope
 Angina
 Survival drops sharply once these features
develop.75% of patients dead within
three years if surgery refused or could not
be carried out.
 AS +CAD has worse prognosis.
AHA/ACC guidelines
Class I
 Symptomatic

severe AS
 Asymptomatic
severe AS but
undergoing other
cardiac surgery

Class II





Asymptomatic
moderate AS
undergoing other
cardiac surgery
Asymptomatic
severe AS+LVF
Abnormal exercise
response
Valve replacement
 Mechanical(Bileaflet

valves)

 Tissue
 Ross

manouver.
 AV debridement.No appreciable
benefit.Restenosis almost invariable.
AORTIC REGURGITATION
1.
2.
3.
4.

Usually aymptomatic until middle age
Left sided failure or chest pain.
Long list of causes
Charecteristic physical signs
Causes









Rhuematic fever
Infective
endocarditis
Degerative
Calcific(usually with
AS)
Acute MI
Trauma
Aortic root diseae
Aortic dissection









Hypertension
Dilated
cardiomyopathy
Syphilis
Marfans syndrome
Osteogenesis
imperfecta
Other collagen
diorders
Spondyloarhropathy
Physical signs










Pulse(water hammer)
Quinke‟s sign
Lighthouse sign
Corrigan‟s pulse
Demusset‟s sign
Pistol shots over
femoral pulse(traube‟s
sign)
Drouziez murmer
Hill sign









Heaving apex
Early diastolic
murmer at LUSE
Other signs of LV
dysfunction/CCF
S4,S3
Austin flint murmer
Signs related to any
other underlying
cause
Symptoms
 Palpitations
 Symptoms

of heart
failure(Fatigue,weakness)
 Exertional dysponea,orthopnea,PND
Investigations
 CXR-increased

CTR,pulmonary congestion
 ECG-LVH with strain,ischaemia,arrythmias
 Echo-diagnostic
LV dimensions
degree of regurgitation
ejection fraction
 Cath studies,CT,MRI
Management












Acute AR-VD,inotropes,surgery
chronicAR
control HTN
antiarryhmics
diuretics
ACEI/ARB‟s
nitrates
low dose beta blockers
inotropes,digoxin
SBE prophlaxis
Surgery in AR
 Acute

AR
 ChronicAR-NYHA 3-4
 EF>55 but<35
 LVED>55
 Valve replacement only
 Reconstructive surgery not an option
Prognosis


Asymptomatic with normalLV function






Asymptomatic patients with LV dysfunction




progression to ccf
<6%/year
Progression to asymptomatic LV dysfunction
<3.5%/year
Sudden death
0.2%/year

Progression to cardiac symptoms>25%/year

Symptomatic patients


Mortality rate

>10%/year
THANK YOU
“for patient listening”

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