Given the fact that Information and Communication Technologies (ICT) today are developing in the direction of ubiquitous and pervasive computing, and that linguistic content items are increasingly combined with or embedded in non-linguistic content items (and vice versa), a systemic and generic approach to data modelling and content management has become the order of the day. Content integration and content interoperability are the key concepts in this connection. In many applications, such as in eAccessibility/eInclusion, content often must be totally reliable – therefore, it needs certification and validation for many different kinds of content. Standards-based datamodels and standardized content facilitate such certification and validation, which also should be based on standards. Needless to say that the above-mentioned approach has a big impact on software development, as can be gathered from document MoU/MG/05 N0221 "Semantic Interoperability and the need for a coherent policy for a framework of distributed, possibly federated repositories for all kinds of content items on a world-wide scale", which was adopted in 2005. See: http://isotc.iso.org/livelink/livelink/fetch/2000/2489/Ittf_Home/MoUMG/Moumg221.pdf. It also has an impact on future ICT-related standards as can be seen from MoU/MG/05 N0222 "Statement on eBusiness Standards and Cultural Diversity". See: http://isotc.iso.org/livelink/livelink/fetch/2000/2489/Ittf_Home/MoUMG/Moumg222.pdf. Increasingly required today are modularity and comprehensive interoperability, capability for multilinguality and multimodality, based on open standards. Fulfilling these requirements will make software and database design fit for eAccessibility/eInclusion from the outset. It will also make content – first of all structured content at the level of lexical semantics – fit for different kinds of content integration and content interoperability. Such structured content – especially if standardized and made available in the form of content repositories – enhances the potential for re-use in totally different eApplications. It also increases the reliability of data, thus reducing the risk of all sorts and liability. This contribution attempts to show how standards-based approaches for content standardization, content management, content related services and tools and their certification not only guarantee reliable content integration and content interoperability, but also are of particular benefit to people with special needs in eAccessibility/eInclusion.