Atherosclerotic plaque: Radionuclide Imaging

Atherosclerotic plaque: Radionuclide Imaging Human Adams

Introduction Genomics Proteomics (complex) molecular pathways Atherosclerotic plaque Molecular ‘events’ Stenosis

Introduction – Role of molecular imaging Genomics Proteomics (complex) molecular pathways Molecular ‘events’ Stenosis (unstable) plaque Reperfusion ,[object Object],[object Object],[object Object],[object Object],Angiography Therapy

The “Vulnerable plaque” ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Introduction – non-invasive molecular imaging Molecular Imaging? Selection of target Synthesizable probe Labelling for Imaging modality ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],T/S resolution Signal sensitivity Practical limitations

Introduction – Radionuclide imaging ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Positron emission (Beta+) Cosmic background radiation / year: 1,5-2 mSv Flight crew: 2-5 mSv Radiolabeling

Radionuclide imaging of the plaque

Radionuclide imaging of the plaque ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Radionuclide imaging of the plaque: 18 F-FDG PET -CT JNM 16-3-’09

Radionuclide imaging of the plaque: 18 F-FCH PET -CT JNM 16-3-’09 Matter et al

Radionuclide imaging of the plaque ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Radionuclide imaging of the plaque: 125 I-MCP-1

Radionuclide imaging of the plaque ,[object Object],[object Object],[object Object],[object Object],[object Object]

Radionuclide imaging of the plaque: 124 I-CD68-Fc ,[object Object]

Radionuclide imaging of the plaque: Annexin V ,[object Object]

Conclusions: Radionuclide imaging of the plaque ,[object Object],[object Object],[object Object],[object Object],Clinical perspective Langer et al. JACC Vol. 52, No. 1, 2008 radionuclide Imaging in Atherosclerosis

Atherosclerotic plaque: Radionuclide Imaging

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