2. 2
IP
no. : 220024
UNIT
: medicine 1
AGE
: 50 yrs
SEX
: male
WEIGHT
: 63 Kgs
Monday, February
17, 2014
3. 3
Monday, February 17,
2014
Reasons for admission :
c/o :
swelling of legs x 1 month (PEDAL EDEMA)
Distention of abdomen x 1 month
(ASCITIS)
constipation x 1 month
4. 4
Monday, February 17,
2014
PMHx :
Admitted
for similar complaints 5 months
back
Was asymptomatic for 4 months
k/c/o hypertension x 6 months was on
tab. Meto-ER (metprolol ) 50 mg
Has been diagnosed with GERD and
GASTRITIS on 8/02/2012
5. 5
Monday, February 17,
2014
SHx :
Chronic
alcoholic x 15 yrs.
Smoker x 15 yrs. Left 1 year back
No Hx of hematuria , yellow discoloration ,
malena and fever
10. 10
Monday, February 17,
2014
Decompensated cirrhosis ?
In
patients with previously stable cirrhosis,
decompensation may occur due to
various causes, such as
constipation
infection (of any source)
increased alcohol intake
medications
bleeding from esophageal varices
dehydration.
11. 11
Monday, February 17,
2014
Patients with decompensated cirrhosis
generally require admission to hospital, with
close monitoring of the fluid balance, mental
status,
emphasis on adequate nutrition and medical
treatment - often with
Diuretics
Antibiotics
laxatives
thiamine
occasionally steroids
Administration of saline is generally avoided.
32. 32
Monday, February 17,
2014
SUBJECTIVE EVIDENCE
Swelling
of legs x 1 month
Distention of abdomen
others
K/C/O liver cirrhosis with portal
hypertension and essential hypertension
SHx : alcoholic x 15 yrs
33. 33
Monday, February
17, 2014
OBJECTIVE EVIDENCE
Hb
: 8.8 g/dl
ESR : 120 mm/Hr
Urea : 80 mg/dl
Decreased total protein and albumin
Elevated bilirubin 0.42 mg/dl ( 0 – 0.2 )
34. 34
Monday, February 17,
2014
FINAL DIAGNOSIS
Based
on subjective and objective
evidence the patients was diagnosed as
ALCOHOLIC LIVER DISEASE with PORTAL
HYPERTENSION and ESSENTIAL
HYPERTENSION
35. 35
Monday, February 17,
2014
cirrhosis
Cirrhosis
is a consequence of chronic liver
disease characterized by replacement of
liver tissue by fibrosis , scar tissue and
regenerative nodules (lumps that occur
as a result of a process in which
damaged tissue is regenerated),leading
to loss of liver function
36. 36
In
Monday, February
17, 2014
alcoholic cirrhosis, the nodules are
usually <3 mm in diameter; this form of
cirrhosis is referred to as micronodular
37. 37
Monday, February 17,
2014
Risk Factor
Comment
Quantity
In men, 40–80 g/d of ethanol produces
fatty liver
160 g/d for 10–20 years causes hepatitis or
cirrhosis.
Only 15% of alcoholics develop alcoholic
liver disease
Gender
Women exhibit increased susceptibility to
alcoholic liver disease at amounts >20 g/d;
two drinks per day probably safe.
43. 43
MELD
Monday, February 17,
2014
score calculation takes into
account a patient’s :
serum creatinine, bilirubin, international
normalized ratio (INR),
etiology of liver disease,
omitting the more subjective reports of
ascites and encephalopathy used in the
Child-Pugh system.
44. 44
Monday, February 17,
2014
GOALS OF TREATMENT
Assess
the risk for variceal bleeding and
begin pharmacologic prophylaxis where
indicated, reserving endoscopic therapy
for high-risk patients or acute bleeding
episodes
The patient should be evaluated for
clinical signs of ascites and managed
with pharmacologic treatment (e.g.,
diuretics) and paracenteses.
45. 45
Prevention
Monday, February 17,
2014
of complications, achieving
adequate lowering of portal pressure with
medical therapy using beta-adrenergic
blocker therapy, or supporting abstinence
from alcohol.
Careful monitoring for spontaneous
bacterial peritonitis should be employed
in patients with ascites who undergo
acute deterioration
Frequent monitoring for signs of hepatorenal syndrome, pulmonary insufficiency,
and endocrine dysfunction is necessary
46. 46
Hepatic
Monday, February 17,
2014
encephalopathy is a common
complication of cirrhosis and requires
clinical vigilance and treatment with
dietary restriction, elimination of central
nervous system depressants, and therapy
to lower ammonia levels
prevent symptoms and maintain
reasonable QOL
To provide adequate nutritional support
47. 47
Monday, February 17,
2014
TREATMENT OPTIONS
Patient
specific :
for portal hypertension
Propranalol
nadolol
for
Ascites:
aldosterone antagonists (spiranolactone)
loop diuretics
49. 49
Monday, February 17,
2014
GOALS ACHIEVED
Paracenteses
was started on day 1(1000
ml fluid was removed ) and patient was
feeling relived from his abdominal
distention
Patient was feeling better by day 8 and
was discharged on request.
50. 50
Monday, February 17,
2014
PROBLEMS IDENTIFIED
Untreated
indication : ANEMIA
PT/INR was not repeated
Patient was not started on antibiotics as a
prophylaxis for spontaneous bacterial
peritonitis
Patient was not started on syrup lactulose
even though patient was on high risk to
develop encephalopathy
51. 51
Monday, February 17,
2014
MONITORING PARAMETERS
Liver
function test
BLOOD SUGAR
Blood Pressure
Electrolytes (Na and K)
body weight
prothrombin time
Complete hemogram
USG Abdomen
53. 53
About the disease
Non curable disease.
Risk factor
Signs and symptoms
Monday, February 17,
2014
54. 54
About medication
Name and purpose
Dose and frequency
Medication adherence
Possible adverse effects
Missed dose
Monday, February
17, 2014