In the pharmaceutical inorganic chemistry as per PCI topic is Dental product

1. Mr. Harangule Y. R.
Assistant professor
M.Sc. Organic chemistry B.Ed
Latur College of Pharmacy,Hasegaon

2. DENTAL PRODUCTS

3. TOOTH DECAY
 It is a destructive process causing decalcification of tooth &
leading to continue destruction of enamel, dentine & cavity of tooth.

4. TOOTH DECAY
Causes :
1. It is mainly due to action of acids, mostly lactic acid produced from
oral bacterial metabolism of dietary carbohydrate.
2. It is mainly due to accumulation of food particles in tooth.

6. DENTAL PRODUCTS
1. Anticaries agents
2. Cleaning agents / Abrasive
3. Polishing agents / Dentifrices
4. Desensitizing agents

7. 1. ANTICARIES AGENTS
 The agents used to prevent caries or decay and used in the
treatment of same.
e.g. Fluorides.

8. Role of Fluorides
I. Mechanism of Fluoride acts as anticaries .
1. Role of fluoride in preventing dental caries is well
accepted .
2. Administration of small quantity of Fluoride in dental
products may produces good results.
3. It acts by two mechanisms :
A. Fluoride decreases solubility of enamel in lactic acid
(Lactic acid is formed during the partial digestion of
carbohydrates. This acid has ability to dissolve the
enamel)
B. Fluoride act by inhibiting growth of bacteria.

9. Role of Fluorides
II. Fluoride having toxicity when they are taken in large
quantity.
III. Dental fluorosis: When more quantity of fluoride is
ingested , it is carried to bones and teeth to produces
mottled enamel `which is known as dental fluorosis.
IV. Fluoride are carcinogenic when deposited on teeth.

10. 2. Cleaning agents/ Abrasive
1. These are preparation used in cleaning & polishing of teeth.
2. Cleaning agents must remove stains from teeth.
3. A good cleaning agents generally have coarse to fine particle
size.
e.g. Dicalcium Phosphate .

11. 3. Polishing agents / DENTIFRICES:
 DENTIFRICES:
The substance used for purpose of cleaning accessible surface of
teeth. Available in paste and powder form.
E.g. Calcium carbonate, Magnesium carbonate.

12. 4. DESENSITIZER
i. The agent decrease hypersensitivity of teeth when applied to
their outer surfaces.
ii. Some time teeth becomes sensitive to heat and cold.
iii. Some desensitizing agents are incarporated in dental
products to reduces sensitivity of teeth to heat and cold.
e.g. Zinc chloride solution, Strontium chloride.

13. 1. SODIUM FLOURIDE[NaF]
 PROPERTIES
1. It is colourless, odourless crystals which is soluble in water
and insoluble in alcohol.
2. Acidification of solution produce hydrofluoric acid.
3. Aq. Solution of salt leads to corrode common or ordinary
glass bottle & hence stored in pyrex glass.
4. Solution used for dental use made with distilled water.

14. STORAGE:
1. Stored in dark air tight pyrex bottle.
2. Storage not exceed 6 months.
 DOSE:
2.2 mg/day
 APPLICATION:
1.5-3 ppm in water, topically as 2% solution to teeth.

15.  USES:
1. Used for tooth decay.
2. Its 2% solution in water is applied to children teeth.
3. Paste containing 75% NaF & 25% glycerol applied to teeth,
rubbed for 1 min. & remove by mouthwash.
4. It is constituent of some insecticides & rodenticides.

16. 2. STANNOUS FLOURIDE [Snf2]
 PROPERTIES:
1. It is colourless crystalline powder, bitter salty taste.
2. Freely soluble in water & insoluble in alcohol.
3. Aq. Solution are acidic & on standing slowly develop white
ppt. & hence never made up into stock solution.
4. Excess exposure to air is avoided because its tendancy to
oxidised into stannic flouride.

17. STORAGE:
Stored in air tight containers.
Handling in excessive humid condition is avoided.
USES:
1. Used in prevention of caries.
2. Stannous ions increase anticarcinogenic activity of flouride
ions.
 DOSE:
2.2 mg/day
 APPLICATION:
1.5-3 ppm in water, topically as 2% solution to teeth.

18. 3. Dibasic Calcium Phosphate
 Synonym: Calcium monohydrogen phosphate.
 Formula: CaHPO4
 Properties:
1. White odourless powder with slight saline taste.
2. Insoluble in water and in alcohol.
3. Easily soluble in dil.HCl and HNO3.
 Storage: it is stored in well-closed containers.
 Uses:
1. Electrolyte replenisher.
2. As a cleansing agent in toothpaste and powder.
3. As a source of calcium and phosphate.
4. Additive in tablet formulation

19. 4. Zinc Chloride
 Synonym: Buffer of zinc.
 Formula: ZnCl2
 Properties
1. White crystalline powder.
2. Odorless, tasteless,
3. Soluble in water, alcohol and glycerin.
4. It is deliquescent.
 Storage: it absorbs CO2, therefore, should be stored in tightly
closed containers.
 Uses:
1. Desensitizing agent.
2. Mild astringent, mild antiseptic.
3. Used in mouthwash and gargles.
4. Used in deodorant and talcum powders.

20. 5. StrontiumChloride
Formula: SrCl2. 6 H2O
Properties:
1. It occurs as colorless crystals or white
granules.
2. Tasteless, odorless.
3. Soluble in water and alcohol.
4. It effloresces in dry air.
Storage: It should be stored in well closed
containers.
Uses:
1. Desensitizing agent.
2. Used in toothpaste and tooth powder.