Sifiliz

SİFİLİZ Prof. Dr. Aysel Gürler

Sifiliz (Frengi) ETKEN Treponema pallidum (Spiroketa pallida)

Sifilizde bulaşma ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

SINIFLANDIRMA ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

EDİNSEL SİFİLİZ İNKUBASYON SÜRESİ 15-110 GÜN ORTALAMA 3 HAFTA

BİRİNCİ DEVİR SİFİLİZ BELİRTİLERİ ,[object Object],[object Object],[object Object],[object Object],Ağrı yakınması (-)

ŞANKR ÇEŞİTLERİ ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

ŞANKR LOKALİZASYONLARI ( GENİTAL BÖLGE) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

ŞANKR LOKALİZASYONLARI (EKSTRAGENİTAL) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

BİRİNCİ DEVİR SİFİLİZ BELİRTİLERİ ŞANKR ÇIKIŞINDAN 4-6 HAFTA SONRA KAYBOLUR

İKİNCİ DEVİR SİFİLİZ BELİRTİLERİ ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

SİFİLİZ MAKULOZA (ROSEOLA SİFİLİTİKA)

SİFİLİZ PAPULOZA ,[object Object],[object Object],[object Object]

SİFİLİZ PAPULOZA MİLİARİS ,[object Object],[object Object],[object Object],[object Object],[object Object]

SİFİLİZ PAPULOZA LENTİKÜLARİS ,[object Object],[object Object],[object Object],[object Object]

PARMAK ARASINDA PAPÜL EROZİVLER

SİFİLİZ PAPULOZA NUMULARİS ,[object Object],[object Object],[object Object],[object Object]

SİFİLİZ PÜSTÜLOZA ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

KÜÇÜK PÜSTÜLLÜ SİFİLİZ (AKNE SİFİLİTİKA) ,[object Object],[object Object],[object Object]

BÜYÜK PÜSTÜLLÜ SİFİLİZ (VARİOLA SİFİLİTİKA) ,[object Object],[object Object],[object Object],[object Object]

SİFİLİZ ÜLSEROZA ,[object Object],[object Object],[object Object]

SİFİLİZ ÜLSEROZA (RUPİA SİFİLİTİKA)

BELİRLİ YERLERDE LOKALİZASYON GÖSTEREN 2.DEVİR BELİRTİLERİ ,[object Object],[object Object],[object Object],[object Object],[object Object]

MUKOZA LOKALİZASYONU GÖSTEREN İKİNCİ DEVİR BELİRTİLERİ ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

MUKOZA LOKALİZASYONU GÖSTEREN PAPÜLLER (PLAK MÜKÖZ) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

MUKOZA LEZYONLARINDA AYIRICI TANI ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

EL İÇİ AYAK TABANI LOKALİZASYONUNDA YERLEŞEN SİFİLİZ BELİRTİLERİ ,[object Object],[object Object]

ELDE LOKALİZE SİFİLİZ PAPÜLLERİ

SİFİLİZ 2.DEVİR TIRNAK BELİRTİLERİ ,[object Object],[object Object]

SİFİLİZ 2.DEVİRDE GÖRÜLEN SAÇ DÖKÜLMELERİ (ALOPESİA SİFİLİTİKA) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

ALOPESİA AREOLARİS SPESİFİKA Güve yemiş kürk manzarasında görünüm

2.DEVİR SİFİLİZDE PİGMENT BOZUKLUKLARI ,[object Object],[object Object],[object Object],[object Object]

SİFİLİZ 2.DEVİRDE GÖRÜLEN SİSTEMİK BELİRTİLER ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

SİFİLİZ MALİGNA PREKOKS ,[object Object],[object Object],[object Object],[object Object]

İKİNCİ DEVİR SİFİLİZ YAKLAŞIK İKİ YIL DEVAM EDER

LATENT SİFİLİZ ,[object Object],[object Object],[object Object]

LATENT SİFİLİZ YAKLAŞIK ON YIL DEVAM EDER

GEÇ SİFİLİZ (3.DEVİR SİFİLİZ) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

ERİTEM TERSİYER ,[object Object],[object Object],[object Object],[object Object],[object Object]

SİFİLİZ GOMU ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

GOMLARIN OLUŞUM VE SEYİRLERİ ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

GOMLARA BAĞLI KOMPLİKASYONLAR ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

SİFİLİZ TUBEROZA ,[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],SİFİLİZ TUBEROZA-SINIFLANDIRMA

ÜÇÜNCÜ DEVİR SİFİLİZDE DİĞER TUTULUM BÖLGELERİ ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

KEMİK TUTULUMU ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

ORAL MUKOZA BELİRTİLERİ ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

ÜREME ORGANLARINA AİT BELİRTİLER ,[object Object],[object Object],[object Object]

GÖZ TUTULUMU ,[object Object],[object Object],[object Object],[object Object],[object Object]

SİNİR SİSTEMİ TUTULUMU ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

DİĞER ORGAN TUTULUMLARI ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

KONJENİTAL SİFİLİZ ,[object Object]

SİFİLİZ KONJENİTA KLİNİK TABLOLARI ,[object Object],[object Object],[object Object]

SİFİLİZ FÖTALİS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

SİFİLİZ KONJENİTA PREKOKS (SÜT ÇOCUĞU FRENGİSİ) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

PEMFİGUS SİFİLİTİKUS ,[object Object],[object Object]

RİNİTİS SİFİLİTİKA (KORİZA SİFİLİTİKA) ,[object Object],[object Object],[object Object],[object Object]

PSEUDOPARALİZİ-PARROT (OSTEOKONDRİTİS SİFİLİTİKA) ,[object Object],[object Object],[object Object]

DERİ VE MUKOZA BELİRTİLERİ ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

DALAK BÜYÜMESİ ,[object Object],[object Object],[object Object]

SİFİLİZ KONJENİTA TARDA ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

HUTCHİNSON DİŞLERİ En fazla üst kesicilerde olmak üzere kesici dişlerin serbest kenarlarının yarım ay şeklinde çentiklenmesi ile karakterizedir. Bu belirti süt dişlerinin dökülmesinden sonra çıkan sabit dişlerde görülür

SİFİLİZ KONJENİTA TARDA’DA DİĞER BELİRTİLER ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

SİFİLİZDE SEROLOJİK TESTLER ,[object Object],[object Object],[object Object],[object Object],[object Object],Fofolipid yapısındaki antijenlere karşı gelişen IgM ve IgG antikorlarının saptanmasına yönelik testler Treponema palliduma karşı gelişen IgM ve IgG antikorlarının saptanmasına yönelik test

SEROLOJİK TESTLERİN POZİTİFLEŞMESİ ,[object Object],[object Object],[object Object],[object Object]

SEROLOJİK TESTLERİN SPESİFİKLİĞİ ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

1.VE 2.DEVİR SİFİLİZ OLGULARINDA SPİROKET ARANMASI Karanlık alan mikroskopisi yöntemi kullanılarak yapılır

SİFİLİZ TEDAVİSİ-1 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

SİFİLİZ TEDAVİSİ-2 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

SİFİLİZ TEDAVİSİ-3 ,[object Object],[object Object],[object Object],[object Object],[object Object]

SİFİLİZLİ HASTALARIN İZLENMESİ ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

AİDS Acquired immunodeficiency syndrome

AIDS ,[object Object],[object Object],[object Object],[object Object],[object Object]

AIDS’DE BULAŞMA ,[object Object],[object Object],[object Object]

AIDS’DE RİSK GRUPLARI ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

AIDS’DE İNKUBASYON SÜRESİ VÜCUT DİRENCİNE GÖRE AYLARCA VEYA YILLARCA SÜRER

AIDS’IN EVRELERİ ,[object Object],[object Object],[object Object],[object Object]

LATENT DÖNEM Virüs CD4(+) Lenfosit (Th) makrofaj Tetikleyici faktörler Hücre ölümü

AIDS’TE GÖRÜLEN LABORATUAR BULGULARI ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],ANTİJENLERE KARŞI ANTİKOR CEVABI OLUŞAMAZ

LATENT DÖNEM BULGULARI ,[object Object],[object Object],[object Object]

PERSİSTAN GENERALİZE LAP EVRESİ Ekstra inguinal, En az iki anatomik bölgede yerleşmiş, En az 1cm çapında , En az 3 aydır olan LAP’lar

AIDS RELATED COMPLEX EVRESİ ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

AIDS RELATED COMPLEX EVRESİ ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

TERMİNAL DÖNEM ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

TERMİNAL DÖNEM ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

AIDS’TE TANI VE TEDAVİ ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Ulcus Molle ( Şankroid) ,[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object]

Klinik Belirtiler ,[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object]

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