2. Safe Harbor
This presentation may contain forward-looking statements, which reflect the Company's current
expectation regarding future events. These forward-looking statements involve risks and uncertainties that
may cause actual results, events or developments to be materially different from any future results, events
or developments expressed or implied by such forward-looking statements. Such factors include, but are
not limited to, changing market conditions, the successful and timely completion of clinical studies, the
establishment of corporate alliances, the impact of competitive products and pricing, new product
development, uncertainties related to the regulatory approval process or the ability to obtain drug product
in sufficient quantity or at standards acceptable to health regulatory authorities to complete clinical trials or
to meet commercial demand, and other risks detailed from time to time in the Company's ongoing
quarterly and annual reporting. Certain of the assumptions made in preparing forward-looking statements
include but are not limited to the following: that our JAK1/JAK2 inhibitor CYT387, nimotuzumab and our
VDA small molecule CYT997 will generate positive efficacy and safety data in future clinical trials, and that
YM and its various partners will complete their respective clinical trials within the timelines communicated.
Except as required by applicable securities laws, we undertake no obligation to publicly update or revise
any forward-looking statements, whether as a result of new information, future events or otherwise.
2 YM Corporate Presentation | Calendar Q2/2012
3. Corporate Information
Net Cash (Mar 31, 2012) $137.2mm
Cash used in last 12 months (Dec 31, 2011) $26.7mm
Market cap (May 8, 2012) $282mm
Volume (3-month average) ~1.1mm shares/day
Total shares outstanding (Mar 31, 2012) 157.4mm
Warrants @ $1.60 (to Mar 10, 2015) 7.4mm
Options1 (Mar 31, 2012) 8.2mm
No debt or preferred shares
1 Weighted average exercise price $1.92
3 YM Corporate Presentation | Calendar Q2/2012
4. YM BioSciences
Product Preclinical Phase I Phase II Phase III
CYT387
JAK1/JAK2 inhibitor
Positive interim Phase I/II myelofibrosis data
presented at ASH 2011
Nimotuzumab
EGFR targeting antibody
Multiple Phase II and Phase III trials
CYT997
Tubulin inhibitor
IV + oral formulation development
Kinase Inhibitor Library
~4000 molecules including JAK RA candidates
1 Weighted average exercise price $1.99
4 YM Corporate Presentation | Calendar Q2/2012
5. Target Markets for JAK Inhibitors
Autoimmune Myeloproliferative Cancer /
Diseases Neoplasms Hematology
– Rheumatoid – Myelofibrosis – Leukemia and
Arthritis Lymphoa
– Polycythemia Vera
– Psoriasis – Solid Tumors
– Essential
– Graft vs. Host Thrombocythemia – Other Hematologic
Disease Disorders
Chronic Disorders Clinical Proof of Concept Acute Diseases
5 YM Corporate Presentation | Calendar Q2/2012
6. Our Significant Expertise in JAK Research
YM acquired original intellectual assets Intellectual Property
in JAK field
CYT387 Composition of Matter
– Lead product CYT387
US: Pending, 2028 expiry
– Wholly-owned and un-partnered EU: Pending, 2028 expiry
– First group to publish crystal JAK2 Crystal Structure
structures of JAK2 and JAK1
US: Issued, 2025 expiry
– Medicinal chemistry and molecular EU: Pending, 2026 expiry
modeling expertise
JAK2 Enzyme
– Novartis collaboration for selective US: Issued, 2015 expiry
JAK3 inhibitors
EU: Issued, 2011 expiry
6 YM Corporate Presentation | Calendar Q2/2012
7. CYT387: A Potent, Selective JAK1/JAK2 Inhibitor
– Highly specific, small molecule, ATP
competitive, JAK1/JAK2 inhibitor
– Rationally designed for optimal JAK binding
– Inhibits cellular proliferation driven by JAK2
or JAK1, but not JAK3 or other mechanisms
– Inhibits STAT phosphorylation downstream
of constitutively active JAK2 or cytokine
stimulated JAK1 or JAK2
– Orally active
– Very favourable preclinical profile
7 YM Corporate Presentation | Calendar Q2/2012
8. Clinical Presentations of Myelofibrosis
– Decreased erythropoiesis or thrombopoiesis
– Proliferation of dysfunctional megakaryocytes
– Hypercellular bone marrow leading to fibrosis
– Extramedullary hematopoiesis
– Elevated cytokine levels
– Anemia – often requiring transfusions
– Thrombocytopenia
– Splenomegaly
– Constitutional symptoms
Fatigue, night sweats, pruritus, bone pain,
weight loss, fever
8 YM Corporate Presentation | Calendar Q2/2012
9. Anemia Impacts Survival in Myelofibrosis
Anemia at diagnosis Anemia at any time
– ~70% of myelofibrosis patients are Intermediate-II or High risk †
– Estimated that 30-50% of all myelofibrosis patient are transfusion dependent‡,
majority of which are Intermediate-II and High risk patients
† DIPSS-Plus; Gangat et al. JCO 2011; 29(4), 392
‡ Elena et al. Haematologica 2011 96(1) 167
9 YM Corporate Presentation | Calendar Q2/2012
10. CYT387: Target Product Profile
CYT387 is able to provide a clinically meaningful benefit to myelofibrosis
patients by:
1. Converting 2. Reducing spleen 3. Improving
transfusion dependent volume in patients constitutional
patients to transfusion with enlarged symptoms and
independent status spleens quality of life
… while having a significantly lower risk of causing
or worsening hematological adverse events such as
thrombocytopenia, anemia and neutropenia.
10 YM Corporate Presentation | Calendar Q2/2012
11. Safety and Efficacy of CYT387
Updated Phase I/II Data – ASH 2011
11 YM Corporate Presentation | Calendar Q2/2012
12. Current Study Status
166 Patient Phase I/II Study
Dose Dose Dose
Dose
Escalation Confirmation Expansion
Extension
Phase Phase Phase
Study
(n = 21) (n = 39) (n = 106) (n = 104)
Initiated Nov 2009 Initiated Aug 2010 Initiated Dec 2010 Enrollment complete
100 mg QD (n=3) Data collection and
150 mg QD (n=3) 150 mg QD (n=18) 150 mg QD (n = 31) analysis ongoing
200 mg QD (n=3) 300 mg QD (n=21) 300 mg QD (n = 33)
300 mg QD (n=6) 150 mg BID (n = 42) 97% of patients
400 mg QD (n=6) entered the Extension
phase as at ASH 2011
DLT level: 400 mg QD Mayo Clinic (Rochester, Minnesota)
MTD: 300 mg QD Dana Farber Cancer Institute (Boston)
Stanford Cancer Center (Stanford)
Mayo Clinic Mayo Clinic Royal Melbourne Hospital (Melbourne)
Princess Margaret Hospital (Toronto)
Jewish General Hospital (Montreal)
12 YM Corporate Presentation | Calendar Q2/2012
13. CYT387 Evaluated in an Advanced Population
CYT387 Ruxolitinib Ruxolitinib Ruxolitinib
Baseline Characteristics Phase I/II Phase III Phase III Phase II
(ASH 2011) (Comfort-1) (Comfort-2) (NEJM)
Primary Myelofibrosis (%) 65% 45% 53% 53%
Post-PV Myelofibrosis (%) 22% 31% 31% 31%
Post-ET Myelofibrosis (%) 13% 24% 16% 16%
Median Hemoglobin (g/dL) 9.5 10.5 10.4 10.4
9
Median Platelets (10 /L) 187.5 262 236 (all pts) 263
9
Median ANC (10 /L) 8.3 Not reported Not reported 12.1
Spleen length (cm) 17 16 15 19
3
Spleen volume (cm ) 3667 2595 2381
< 21% (estd*) < 21% (estd*)
(unspecified
Transfusion dependent (IWG) (%) 44% (Unspecified (Unspecified
criteria)
criteria) criteria)
* Product label cited that 21% of patients had RBC transfusion within 8 weeks of enrollment in the study. Maximum estimation of potential transfusion
dependent patients
13 YM Corporate Presentation | Calendar Q2/2012
14. Subject Disposition
– Median follow-up (range) for Core and Extension: 10.4 months (0.8 – 25.6)
– Median follow-up (range) for Core: 9.0 months (0.8 – 9.0)
– Study discontinuation during Core: n=32 (19%); 81% retention rate
– Reasons for discontinuation during Core (n=32)
> Unrelated comorbid conditions (n=11)
> Subject withdrew consent (n=5)
> Possibly or probably related adverse events (n=5)
– Neuropathy (n=2)
– Cough (n=1)
– Transaminitis (n=1)
– Thrombocytopenia (n=1)
> Disease progression (n=4)
> Investigator’s decision (n=4)
> Stem cell transplant (n=2)
> Intercurrent illness (n=1)
– Deaths during Core n=12 (7%)
– Study discontinuation during Extension n= 16 (21%); 79% retention rate
14 YM Corporate Presentation | Calendar Q2/2012
15. Transfusion Independence Response
150 mg QD 300 mg QD 150 mg BID Total1
Response by Dose
(n=52) (n=60) (n=42) (n=166)
Transfusion dependent at baseline (evaluable; n) 25 26 14 68
Median time on study (days) 251 245 141 250
Transfusion independence rate (12 weeks)* 48% 65% 43%2 54%
Transfusion independence rate (12 weeks & Hgb≥8g/dL)* 40% 62% 29%2 46%
– >25% of subjects not receiving transfusions while on study experienced at least a 1 g/dL increase in Hgb
for ≥ 8 weeks
Time to Response Median Min-Max
Time to confirmed response (12 wks & Hgb≥8 g/dL) (days) 84 84-293
Duration of transfusion-free period (12 wks & Hgb≥8 g/dL) (days) not yet reached 82-506*
1 Includes 100 mg QD (n=3), 200 mg QD (n=3), and 400 mg QD (n=6) doses
2 Not statistically significant vs. 300 mg QD
* Ongoing
15 YM Corporate Presentation | Calendar Q2/2012
16. Maximum Duration of Transfusion-Free Period*
Responders
0 100 200 300 400 500
Time (days)
* To date
16 YM Corporate Presentation | Calendar Q2/2012
17. Spleen Response
150 mg QD 300 mg QD 150 mg BID Total1
Response by Dose
(n=52) (n=60) (n=42) (n=166)
Spleen evaluable (n) 47 51 33 142
Median time on study* (days) 252 225 144 225
Spleen response* (IWG-MRT) 30% 33% 27% 31%
≥50% decrease in palpable spleen length at six months 28% 33% 39% 33%
Median spleen decrease at six months -35% -35% -39% -35%
Primary MF Post-PV MF Post-ET MF
Response by Diagnosis
(n=106) (n=36) (n=24)
Spleen evaluable (n) 88 34 20
Spleen response* (IWG-MRT) 28% 38% 30%
Time to Response Median Min-Max
Time to IWG-MRT response (days) 15 6-260
Duration of response (days) not yet reached 55-574*
1 Includes 100 mg QD (n=3), 200 mg QD (n=3), and 400 mg QD (n=6) doses
* Ongoing
17 YM Corporate Presentation | Calendar Q2/2012
18. Maximal Change in Palpable Spleen Size*
(Core Study; n=142)
80%
≥ 25% decrease from baseline: 87%
60% ≥ 50% decrease from baseline: 49%
≥ 75% decrease from baseline: 25%
100% decrease from baseline: 16%
40%
% Change From Baseline
20%
0%
-20%
-40%
-60%
-80%
-100%
* Ongoing
18 YM Corporate Presentation | Calendar Q2/2012
19. Spleen Response: MRI vs. Palpation
MRI1 (n=11) Palpation (n=11)
Response at three months 64%2 45%3
Median decrease from baseline at three months -41% -45%
– Median spleen volume at baseline 3667 cm3
Spleen Response: Change from Baseline at Three Months
20% Spleen Volume (n=11) Spleen Length (n=11)
0%
% Change from Baseline
-20%
-40% -41%
-45%
-60%
-80%
-100%
1 Includes 1 subject with CT assessment
2 Spleen response defined as a 35% reduction in spleen volume from baseline
3 Spleen response defined as a 50% reduction in spleen length from baseline
19 YM Corporate Presentation | Calendar Q2/2012
20. Constitutional Symptoms Response at Six Months
100%
Complete Resolution
Marked Improvement
90%
80%
Percentage of Patients
70%
60%
89%
50% 57%
52%
44%
40%
30%
30%
20%
10% 23% 22% 23%
19%
11%
0%
Night Sweats Pruritis Bone Pain Cough Fever
(n=62) (n=46) (n=43) (n=27) (n=9)
20 YM Corporate Presentation | Calendar Q2/2012
21. Related Hematologic Adverse Events
Adverse Event (n=166) All Grades Grade 3 Grade 4
Thrombocytopenia 33% 11% 6%
Baseline platelets > 100 x 109/L 26% 6% 2%
Baseline platelets > 200 x 109/L 12% 4% 0
Neutropenia 6% 1% 2%
Anemia 4% 1% 0
Leukopenia 2% <1% <1%
Leukocytosis 1% <1% 0
At least possibly related to study drug
Common Terminology Criteria for Adverse Events v3.0
21 YM Corporate Presentation | Calendar Q2/2012
22. Related Non-Hematologic Laboratory Adverse Events
Adverse Event (n=166) Incidence ≥ 10% All Grades Grade 3 Grade 4
Dizziness1 20% 0 0
Neuropathy peripheral 20% 0 0
Diarrhea 18% 0 0
Nausea 17% 0 <1%
Headache 12% 1% 0
Adverse Event (n=166) All Grades Grade 3 Grade 4
First Dose Effect2 20% 0 0
Dizziness 11% 0 0
Flushing 5% 0 0
Hypotension 6% 0 0
1 Includes First Dose Effect At least possibly related to study drug
2 Only events occurring on first dose date Common Terminology Criteria for Adverse Events v3.0
22 YM Corporate Presentation | Calendar Q2/2012
23. Related Non-Hematologic Laboratory Adverse Events
Adverse Event (n=166) Incidence ≥ 5% All Grades Grade 3 Grade 4
ALT increased 8% 2% 0
Lipase increased 8% 4% 0
AST increased 7% 1% <1%
Amylase increased 6% 0 0
Bilirubin increased 6% 0 0
Creatinine increased 6% 0 0
At least possibly related to study drug
Common Terminology Criteria for Adverse Events v3.0
23 YM Corporate Presentation | Calendar Q2/2012
24. CYT387 – Safe, Effective, Differentiated
CYT387 treatment results in significant, durable responses in anemia,
splenomegaly and constitutional symptoms at 150 mg QD, 300 mg QD and
150 mg BID dose levels
– Therapeutic benefit and safety established in a population with multiple risk
factors, including anemia and thrombocytopenia
– CYT387 anemia benefit appears unique among the current class of JAK1 and
JAK2 inhibitors
– Clinically relevant maintenance of transfusion independence period
– MRI performed in a subset of subjects confirms the meaningful improvement in
splenomegaly measured by palpation
– Complete resolution or marked improvement of common constitutional
symptoms is achieved in the majority of subjects
24 YM Corporate Presentation | Calendar Q2/2012
25. CYT387 – Safe, Effective, Differentiated
CYT387 is well tolerated in myelofibrosis patients for dosing periods up to and
exceeding two years
– Reported adverse effects include thrombocytopenia; transient, mild dizziness;
mild peripheral neuropathy; and abnormalities in liver/pancreas-related laboratory
tests
– Treatment-emergent anemia and neutropenia are rare
Although additional assessments and analyses are ongoing, 300 mg QD
appears to be a safe and effective dosing regimen that warrants further clinical
development
25 YM Corporate Presentation | Calendar Q2/2012
26. CYT387 Has the Best Fit in Myelofibrosis
Variable Diagnosis* >1 year* CYT387
Anemia 38% 64% Benefit
Transfusion dependency 25% 45% Benefit
Thrombocytopenia 18% 31% Minimal
Palpable spleen >10cm 21% 46% Benefit
Constitutional symptoms 29% 34% Benefit
– CYT387 has a superior profile to other JAK inhibitors in relation to clinical needs
and overarching risk factors
> Superior benefit on anemia and transfusion dependency
> Comparable activity for spleen and symptoms
> Less myelosuppression
* Mayo Clin Proc 2012;87(1): 25-33
26 YM Corporate Presentation | Calendar Q2/2012
27. CYT387
Next Steps
27 YM Corporate Presentation | Calendar Q2/2012
28. CYT387 BID Study Design
Dose Starting at 200mg BID, increasing by 50mg BID
escalation Recruiting approximately 60 patients
study Initiated in calendar Q3 2011
– Designed to explore BID schedule to complement QD MTD
– Spleen response measured by palpation and MRI
– Constitutional symptoms assessed using the Myelofibrosis Symptom Assessment
Form (MFSAF)
– To assess anemia response, a minimum three months of transfusion history will be
collected
– Comprehensive blood work and biomarkers being recorded for
correlative/mechanistic studies
Mayo Clinic MD Anderson Huntsman Cancer Princess Margaret Jewish General
(Arizona) (Texas) Institute (Utah) (Ontario) (Quebec)
* Mayo Clin Proc 2012;87(1): 25-33
28 YM Corporate Presentation | Calendar Q2/2012
29. CYT387 Myelofibrosis Development Pathway
Extension
study
166-patient
Phase I/II
Dec 2010 Q2 2011 Q3 2011 Q4 2011 Q4 2012
Interim data Interim data Completed Multicenter Report final core
at ASH at ASCO enrollment data at ASH study data &
extension study
data
~60 patient Phase II BID
Q3 2011 Q4 2012
Initiated enrollment Report data
Pivotal program
H2 2012
Initiate enrollment
29 YM Corporate Presentation | Calendar Q2/2012
30. CYT387 Development and Commercial Opportunities
Myeloproliferative Hematological Solid
Neoplasms Disorders Tumors
– Myelofibrosis – Myelodysplastic – Prostate cancer
First line Syndromes (MDS) – Hepatocellular
Ruxolitinib failures – Multiple Myeloma – NSCLC
Combinations – AML, CML, ALL – Gastric
– NHL, Lymphoma – Colorectal
– PV/ET – Etc.
– Orphan MPNs
Clinical proof-of-concept Expand hematological Market expansion
Speed to market strategy indications/franchise Lifecycle management
30 YM Corporate Presentation | Calendar Q2/2012
31. Promising Pipeline – Exciting Future
CYT387 Nimotuzumab CYT997
JAK1/JAK2 inhibitor anti-EGFR mAb Tubulin inhibitor
Oral, small molecule Prospect for enhanced safety Small molecule vascular
in “billion dollar” class disrupting agent (VDA)
Wholly owned, unpartnered
and differentiated De-risked, over 10,000 Phase I clinical proof of
patients dosed concept demonstrated
Potentially very broad utility
(hematology, liquid tumors, Partners advancing Phase Phase II (iv) in glioblastoma
solid tumors) II’s and III’s globally multiforme
Multicenter Phase I/II data YM retains North American Reformulating as an oral
in myelofibrosis reported rights drug
at ASH 2011
Kinase Inhibitor Preclinical Research Programs
31 YM Corporate Presentation | Calendar Q2/2012
32. 32 YM Corporate Presentation | Calendar Q2/2012