Pharmacology Third Year

1. Pharmacology: First major Exam – dental - 2013
Q-1: Define pharmacokinetics of drug:
……………………………………………………………………………………………………………………………………
Q-2: Define bioavailability:
……………………………………………………………………………………………………………………………………
Q-3: Write the following:
a. Two advantages of intravenous of drug administration:
1. …………………………………………………………………………………
2. …………………………………………………………………………………
b. Two factors that may affect drug absorption:
1. ………………………………………………………………………………
2. ………………………………………………………………………………
Q-4: Mention two of the factors affecting renal excretion:
1. ……………………………………………….
2. ……………………………………………….
Q-5: Define the following:
a. Agonist:
………………………………………………………………………………………………………………………..
b. Drug tolerance:
………………………………………………………………………………………………………………………..
Q-6: Mention two unpredictable drug adverse effects:
1. …………………………………………………………………………..
2. …………………………………………………………………………..
Q-7: Mention two drugs causing cytotoxic reaction and mention their cytotoxic
effects:
1. Drug:………………… ……… Cytotoxic reaction:…………………………….……………….
2. Drug:………………… ……… Cytotoxic reaction:…………………………….……………….

2. Q-8: Name two type of cholinergic receptors:
1. ………………………………………………………………….
2. ………………………………………………………………….
Q-9: Write one therapeutic use for each one of the following cholinergics:
a. Pilocarpine:…………………………………………
b. Neostigamine:……………………………………………
Q-10: Mention two adverse effects of anti-cholinergics (e.g. Atropin)
1. ……………………………………………………………
2. ……………………………………………………………
Q-11: Mention one action of anti-cholinergics on the following:
a. GIT:…………………………………………………………………………………
b. Eye: ………………………………………………………………………………..
Q-12: Write two actions of selective 2 agonists (e.g. salbutamol)
1. ………………………………………………………
2. ………………………………………………………
Q-13: Mention two adverse effects of adrenaline:
1. …………………………………………………………..
2. ……………………………………………………………
Q-14: Name the following:
a. One selective 1 agonists:…………………………………………………
b. One selective 1 agonists:…………………………………………………
Q-15: Name two 1 blockers and their uses:
1. Name:………………………………………….,Use:………………………………..….………………..
2. Name:………………………………………….,Use:………………………………..….………………..
Q-16: List four uses of blockers:
1. ……………………………………………………………………
2. ……………………………………………………………………

3. 3. ……………………………………………………………………
4. ……………………………………………………………………
Q-17:
a. Write names of two cardioselective blockers:
1. ……………………………………………………..
2. ………………………………………………………
b. Write two adverse effects of blockers:
1. ………………………………………………………
2. ……………………………………………………….
Q-18: Give two important examples of benzodiazepines and their one clinical use of
each:
Q-19:
a. Name the drug used to treat benzodiazepines overdose:……………………………….
b. Write the mechanism of action of Zolpidem:
………………………………………………………………………………………………………………………..
Q-20:
a. Write the action of histamine on the following
1. Bronchial smooth muscle:…………………………………………………….
2. Blood pressure:…………………………………………………………………….
b. List two important uses of first generation antihistamines:
1. ………………………………………………………………………..
2. ………………………………………………………………………..
Q-21:
a. Give two examples of less/non sedating (2nd
generation) antihistamines:
1. ……………………………………………..
2. ……………………………………………….
b. Write two important adverse effects of 1st
generation antihistamines:
1. ……………………………………………………
2. …………………………………………………….

4. Q-22:
a. Give two examples of antihypertensive drugs that act centrally:
1. ………………………………………………………….
2. ………………………………………………………….
b. List two adverse effects of calcium channel blockers:
1. ………………………………………………………….
2. …………………………………………………………..
Q-23: Mention two important adverse effects and two contraindications of ACE-
inhibitor:
a. Adverse effects:
1. ………………………………………………………..
2. …………………………………………………………
b. Contraindications:
1. …………………………………………………………
2. ………………………………………………………….
Q-24: Write two therapeutic uses of selective 1 agonists:
1. ……………………………………………..
2. ……………………………………………….
Q-25:
a. In the management of anaphylactic shock, write the action of adrenaline on
the following:
1. 1 adrenergic receptors:………………………………………..……………
2. 1 adrenergic receptors:………..………………………….…………………
3. 2 adrenergic receptors:……………………………………………………….
b. Name one important positive inotropic drug used to treat cardiogenic
shock:………………………………………………