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Learner Research - 3D Printing for Personalized Medicine

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Learner Research - 3D Printing for Personalized Medicine

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Learner Research - 3D Printing for Personalized Medicine

  1. 1. 3D Printing for Personalized Medicine In the New Healthcare Era Ryan Klatte, BSBME Principal Research Engineer Lerner Research Institute Jeff Yanof, Ph.D. Senior Principal Research Engineer Lerner Research Institute
  2. 2. September 8, 2016 Tri-C R3D 2016 2 Introduction
  3. 3. September 8, 2016 Tri-C R3D 2016 3 Introduction http://mds.clevelandclinic.org
  4. 4. September 8, 2016 Tri-C R3D 2016 4 Introduction
  5. 5. September 8, 2016 Tri-C R3D 2016 5 Background Medical Imaging Additive Manufacturing Patient-Based Anatomical Model
  6. 6. September 8, 2016 Tri-C R3D 2016 6 Background 3D Printing Technologies Mainstream Additive Manufacturing Technologies Stereolithography Fused Deposition Modeling (Fused Filament Fabrication) Binder Jetting Selective Laser Sintering Polyjet (multi-material jetting) Selective Laser Melting (Electron Beam, Direct Metal Laser Sintering) Continuous Light Interface Production MultiJet Fusion
  7. 7. September 8, 2016 Tri-C R3D 2016 7 Background  3D Printing Features (nearly) Unlimited Geometry
  8. 8. September 8, 2016 Tri-C R3D 2016 8 Background Medical Imaging , Ultrasound, PET, SPECTCT, MRI,
  9. 9. September 8, 2016 Tri-C R3D 2016 9 Background Medical Imaging CT & MRI Visualization
  10. 10. September 8, 2016 Tri-C R3D 2016 10 Medical Education Surgical Planning Medical Device Development Background Medical Imaging Applications
  11. 11. September 8, 2016 Tri-C R3D 2016 11 Background Applications Medical Education Textbook Graphics Video Catalog Model Cadaver Labs
  12. 12. September 8, 2016 Tri-C R3D 2016 12 Background Applications Medical Education
  13. 13. September 8, 2016 Tri-C R3D 2016 13 Background Applications Surgical Planning Tumor Resection Remnant
  14. 14. September 8, 2016 Tri-C R3D 2016 14 Background Applications Medical Devices Endoscope Catheter | Guidewire Pancreatic Duct Bile Duct
  15. 15. September 8, 2016 Tri-C R3D 2016 15 Medical Applications  Patient Specific Models CT/MR Imaging 3D Reconstruction Digital Preparation 3D Printing Post Processing
  16. 16. September 8, 2016 Tri-C R3D 2016 16 3D Printed Model Post Processing Medical Applications  Anatomical Models Training & Education
  17. 17. September 8, 2016 Tri-C R3D 2016 17 3D Printed Model Real Anatomy Viewed through airway endoscope Medical Applications  Anatomical Models Training & Education
  18. 18. September 8, 2016 Tri-C R3D 2016 18 3D Reconstruction Digital Preparation 3D Printed Model Descending Aorta Medical Applications  Anatomical Models Intrasvascular Device Testing Common Iliac External Iliac
  19. 19. September 8, 2016 Tri-C R3D 2016 19 Medical Applications  Anatomical Models Device Testing easy Tortuous Calcifications Diameter changes
  20. 20. September 8, 2016 Tri-C R3D 2016 20 Medical Applications  Surgical Planning Case Study Aortic Arch Aneurysm Case History: • Previous open heart surgery Aortic Arch Aneurysm graft Aortic value replacement Present: Kink in existing Aortic Graft
  21. 21. September 8, 2016 Tri-C R3D 2016 21 Medical Applications  Surgical Planning Case Study Aortic Arch Aneurysm Open Repair vs. Endovascular Approach ?
  22. 22. September 8, 2016 Tri-C R3D 2016 22 Step 1 - Imaging Medical Applications  Arch Aneurysm Surgical Planning
  23. 23. September 8, 2016 Tri-C R3D 2016 23 Step 2 – Image Segmentation Medical Applications  Arch Aneurysm Surgical Planning
  24. 24. September 8, 2016 Tri-C R3D 2016 24 Step 2 – Segmentation Preview Medical Applications  Arch Aneurysm Surgical Planning
  25. 25. September 8, 2016 Tri-C R3D 2016 25 Step 2 – Mesh Preview Medical Applications  Arch Aneurysm Surgical Planning
  26. 26. September 8, 2016 Tri-C R3D 2016 26 Step 2 – Mesh Preview Medical Applications  Arch Aneurysm Surgical Planning
  27. 27. September 8, 2016 Tri-C R3D 2016 27 Step 2 – Segmentation Refinement Medical Applications  Arch Aneurysm Surgical Planning aortic valve graft kink aneurysm Rt. coronary focal calcifi’n
  28. 28. September 8, 2016 Tri-C R3D 2016 28 Step 3 – Digital Preparation Medical Applications  Arch Aneurysm Surgical Planning
  29. 29. September 8, 2016 Tri-C R3D 2016 29 Step 4 – 3D Printing Medical Applications  Arch Aneurysm Surgical Planning
  30. 30. September 8, 2016 Tri-C R3D 2016 30 Step 5 – Post Processing (Cleaning) Medical Applications  Arch Aneurysm Surgical Planning
  31. 31. September 8, 2016 Tri-C R3D 2016 31 Clinical Review Medical Applications  Arch Aneurysm Surgical Planning Open Repair vs. Intravascular (minimally invasive) ?
  32. 32. September 8, 2016 Tri-C R3D 2016 32 Total Shoulder Arthroplasty Medical Applications  Patient Specific Devices Surgical Planning & Intraoperative Tools
  33. 33. September 8, 2016 Tri-C R3D 2016 33 Joseph P Iannotti et al, “ Comparison of Patient-Specific Instruments with Standard Surgical Instruments in Determining Glenoid Component Position”, 2012 Journal of Bone and Joint Surgery Vol 94-A Digital Surgical Planning Medical Applications  Patient Specific Devices Surgical Planning & Intraoperative Tools
  34. 34. September 8, 2016 Tri-C R3D 2016 34 Joseph P Iannotti et al, “ Comparison of Patient-Specific Instruments with Standard Surgical Instruments in Determining Glenoid Component Position”, 2012 Journal of Bone and Joint Surgery Vol 94-A Published Trial Results Outcomes measured Standard Surgical Group (n=16) Glenoid Positioning System Group (n=15) P Value Nonoptimal implant type used during surgery 10 (63%) 1 (7%) < 0.001 Malposition occurrences (version and/or inclination) 14 (44%) 4 (13%) <0.001 Malpositioned Implants 12 (75%) 4 (27%) < 0.01 Medical Applications  Patient Specific Devices Surgical Planning & Intraoperative Tools
  35. 35. September 8, 2016 Tri-C R3D 2016 35 Medical Applications  Surgical Planning Live Donor Liver Transplant Live Donor Liver Transplant Sahani D et al. Radiographics 2004;24:957-967
  36. 36. September 8, 2016 Tri-C R3D 2016 36 Medical Applications  LDLT Surgical Planning Digital Preparation Planned Resection Line Left Lobe Right Lobe Vena Cava
  37. 37. September 8, 2016 Tri-C R3D 2016 37 Medical Applications  LDLT Surgical Planning Surgical Planning & Intraoperative Reference 3D Printed Donor Liver
  38. 38. September 8, 2016 Tri-C R3D 2016 38 Dr. Ingeborg van Kroonenburgh et. al., "Doctor and engineer creating the future for 3D printed custom made implants", Digital Dental News, April 2012 pp. 60-65 Steinert AF1, Sefrin L, Hoberg M, Arnholdt J, Rudert M. “Individualized total knee arthroplasty”, 2015 Apr Orthopade Vol 44(4)290-2, 294-301. doi: 10.1007/s00132-015-3104-1 (published in German) Medical Applications  Future Patient Specific Implants 3D Printed Jaw Implant ConforMIS
  39. 39. September 8, 2016 Tri-C R3D 2016 39 Conclusion Questions? Ryan Klatte • klatter@ccf.org • 216.445.0289 Jeff Yanof • yanofj@ccf.org • 216.445.1944

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