This presentation on "Gout" was presented on course "Clinical Biotechnology" and awarded best presentation of the "7 Minute Presentation" contest.

1. INTRO SYMPTOMS TYPES CAUSES DIAGNOSIS TREATMENT PREVENTON PREVALENCE THANKS
GOUT
PRESENTED BY:
Syeda Kishuara
Begum
Rimi Chowdhury
Fabiha Muniyat
Proma
Syed Lokman

2. INTRO SYMPTOMS TYPES CAUSES DIAGNOSIS TREATMENT PREVENTON PREVALENCE THANKS
FEATURES GOUT RHEUMATOID ARTHRITIS OSTEOARTHRITIS
NATURE Metabolic Disease Inflammatory Disease Degenerative Disease
CAUSE Deposition of uric acid Abnormality in immunity Aging of the joint
MORNING
STIFFNESS
NA 1 Hour 15 Minutes
PAIN Mild Extreme Mild
Gout is a form of inflammatory arthritis characterized by recurrent attacked of a red,
tender, hot and swollen joint caused by defective metabolism of uric acid. Pain
typically comes on rapidly in less than twelve hours.
GOUT - THE DISEASE OF KINGs

3. INTRO SYMPTOMS TYPES CAUSES DIAGNOSIS TREATMENT PREVENTON PREVALENCE THANKS

4. INTRO SYMPTOMS TYPES CAUSES DIAGNOSIS TREATMENT PREVENTON PREVALENCE THANKS
GOUT
Based on Cause
Primary
Enzyme defects
Secondary
Increased nucleic acid
turnover
Chronic renal disease.
Based on Severity
Acute
Warmth, pain, swelling,
reddish discoloration in a
joints
Bed sheet touching the
toe causes severe pain
Chronic
Urate crystals may
appear
Occurs kidney stones

5. INTRO SYMPTOMS TYPES CAUSES DIAGNOSIS TREATMENT PREVENTON PREVALENCE THANKS
Impairment
ofUricAcid
Transpor-
tationin
Renal
Proximal
Tube
Uric acid enters through
OAT1, OAT3, OAT2,
OAT4, URAT1 and
SLC2A9v2 transporters.
Uric acid releases
through SLC2A9v1,
ABCC4, NPT4 and NPT1
transporters.

6. INTRO SYMPTOMS TYPES CAUSES DIAGNOSIS TREATMENT PREVENTON PREVALENCE THANKS
Over
Production
ofUric
Aciddue
todefectin
Enzyme

7. INTRO SYMPTOMS TYPES CAUSES DIAGNOSIS TREATMENT PREVENTON PREVALENCE THANKS
Synovial fluid testing from the joint to looking for uric acid crystals.
Blood test to measure the level of uric acid in blood.
Test for white blood cell count and erythrocytocis sedimentation rate
(ESR) as both may be elevated due to gout in the absence of infection.
Asking question to patient about the symptoms.

8. INTRO SYMPTOMS TYPES CAUSES DIAGNOSIS TREATMENT PREVENTON PREVALENCE THANKS
Medication:
Medications that reduce serum uric acid level like “allopurinol”
that blocks uric acid production, and can be used in people with
renal impairment or urate stones.
“Pegloticase” is administrated as an intravenous infusion which
reduces uric acid level.
“Probencid” may be used if under secretion of uric acid is
present.
Others:
Taking anti-inflammatory medicine for better feeling.
Resting of the joint that hurts.
Don’t taking “aspirine” as it increases the uric acid level in the
blood.

9. INTRO SYMPTOMS TYPES CAUSES DIAGNOSIS TREATMENT PREVENTON PREVALENCE THANKS
Controlling of
body weight.
Consumption of
coffee, Vit-C and
dairy products.
Maintain physical
fitness
Reducing intake
of purine rich
foods
Limit daily intake
of meat, seafood
and alcohol.
Drink plenty of
water and other
fluids.

10. INTRO SYMPTOMS TYPES CAUSES DIAGNOSIS TREATMENT PREVENTON PREVALENCE THANKS
Ref: 1. Kuo et al, Global epidemiology of gout, Nature Reviews Rheumatology 11, 649-662(2015)
2. Statistics by Country for Gout, Right Diagnosis, rightdiagnosis.com/g/gout/stats-country.htm
>10% in
Oceanian Countries
>2% in
North America
>1.3% in
Europe
>0.2% in
Bangladesh
Rare in
undeveloped countries
3.90%
2.90%
0.00%
1.00%
2.00%
3.00%
4.00%
5.00%
2007-08 1988-94
GOUT IN USA (ADULTS)
Male vs Female
Male Female

11. INTRO SYMPTOMS TYPES CAUSES DIAGNOSIS TREATMENT PREVENTON PREVALENCE THANKS
THANKS