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2.  In the whole history of hemophilia, the Jews were first
to recognize it. he enacted a law that if a woman had
two sons and that die from circumcision then her third
child will not be required to circumcised. This shows
that they recognize that women carried hemophilia
gene and passed it down to their sons.
 The hemophilia disease became royal disease because
of Queen Victoria was a carrier and passed the carrier
status down to many of her daughter. In those day
many of the emperor had been infected due to marry
with each other families.

3.  Early 1900s- Fresh blood could be transfused after a
sufficient amount of lost. Blood storage was not practice at
that time. Life expectancy for people with hemophilia was
13 years although some lived longer.
 1950s - Plasma became available although it did not
contain enough of the needed factor.
 1965 - Cryoprecipitate “Cryo” improves treatment a bit.
Basically “Cryo” was what settled to the bottom of a bag of
plasma. It contained more of the needed factor. It was then
frozen and infused, a long hospital procedure
 1970s - Factor concentrates become available.

4.  1980s - Factor concentrates infect 80% of the people
with hemophilia in the U.S with HIV, many have since
passed away.
 1985 - First viral inactivated factor products become
available.
 1992 - First non plasma derived factor becomes available
using recombinant DNA technology.
 1995 - “Prophy” becomes the standard of treatment in
the U.S. Instead of waiting for prolonged bleeding to
occur, factor is taken regularly to prevent bleeding and
increase quality of life.

5. Hemophilia A :- Classic hemophilia,
Factor VIII deficiency .
Hemophilia B :- Christmas disease,
Factor IX deficiency.

6. .Excessive bleeding:- Blood will come
continuously till the ending of blood in your
body.
.Easy bruising:- symptoms range from
increased bleeding after trauma, injury, or
surgery to sudden bleeding with no
apparent cause.

8.  If you have inherited hemophilia, you’re born with the
condition. It caused by a defect in one of the gene that how
the blood make blood clotting factor VIII or IX. These gene
are located on X chromosome.
 Chromosomes come in pairs. Female have two X
chromosome and male have one X and one Y chromosome.
Only X chromosome responsible for the blood clotting
factors.
 A male who has the abnormal gene on X chromosome will
have hemophilia and female have must be both of the X
chromosome has abnormal gene for infection so in female its
rare.
 A female is a “carrier” of hemophilia if she has abnormal gene
on her one X chromosome. Even though she does’nt have
condition she will pass her gene to children.

9. 1 per 5,000 male births
1 per 10,000 population.
85% F-VIII deficiency
10-15% F-IX deficiency
HEMOPHILIA A:B =7:1

10.  By family history
 Its diagnosed by
taking sample and
measuring the level
of factor activity in
the blood.
 Treatment with
replacement
therapy
 Desmopressin
 Antifibrinolytic
 Treatment of a
specific bleeding
site.

11.  Protect toddlers with helmets and knee
pads when riding a bicycle.
 Seat belt, higher chair safety belt,
stroller belt.
 Furniture with sharp edges.
 Keep harmful and dangerous item from
small children.

12.  Doctors who specialized in blood
disorder.
 Social works:- Financial issues,
transportation, and mental health
 Special dentist

13.  Researchers are trying to develop ways to correct the
defective gene’s that cause hemophilia.
 Such as gene therapy hasn't yet
develop to the point that its an
accepted treatment.
 Researchers continue to test
gene therapy for hemophilia
in clinical trails.

14. THE END