WP CLI is a command line interface for WordPress that allows users to create, update, delete, list, and manage posts, users, comments, menus, metadata, cron jobs, plugins, themes, and more through commands. Commands can be chained together and run on local or remote servers. It has useful features like editing wp-config constants, running a WordPress shell, searching/replacing across tables, updating WordPress, clearing cache, optimizing databases, handling cron events, regenerating thumbnails, and scaffolding plugin tests.