2. Terminology to know
All key terms on page 260 Overall Survival (OS)
in Lewis et al Quality of Life (QOL)
Prevalence Benign
Incidence Malignant
Mortality Node
Morbidity Biopsy
Survival Cachexia
Progression Free Survival Cure
(PFS) Control
Disease Free Survival (DFS) Palliation
Adjuvant Hospice
3. Who gets cancer?
Men – Prostate, Lung, Colon/rectum, Bladder, NHL,
melanoma, Head and neck
Women – Breast, Lung, Colon/rectum, Uterus, NHL,
Thyroid, Melanoma, Ovary
Adult age variables – the older the person, the higher the
risk of cancer
Children – very specific childhood cancers, significant
genetic components
Ethnicity variables – page 261
US and rest of the world
Developing nations – very different issues
4. How do people get cancer?
Risk factors
Age, Gender
Environmental influences – carcinogens
Chemical/Radiation/Smoke/Smog/ Water Quality/
Infections/Food Processing
Genetics – 10-15% have genetic link
New research increasing our ability to detect links
Behaviors
Smoking
Dietary
Exercise
ETOH
8. Staging
T – Primary Tumor
is: in situ, x: can’t be found, 0: no evidence of primary tumor
1 – 4: Ascending size
N – Node
0: no evidence of disease, x: unable to assess
1 – 4: Ascending degrees of nodal involvement
M – distant metastases
0: no evidence of distant mets, x: cannot be determined
1 – 4: Ascending degrees of metastatic involvement
Staging related to the formula for the TNM
Stage 0 – 4: the higher the number, the more serious the
disease
Guides decision making about treatment, advises about
prognosis
9. Grading
Grade 1
Differ slightly from normal cells – low grade
Grade 2
Moderate differentiation – intermediate grade
Grade 3
Severe differentiation – high grade
Grade 4
Immature and primitive
The cells of Grade 1 tumors resemble normal cells, and tend to
grow and multiply slowly.
Conversely, the cells of Grade 3 or Grade 4 tumors do not look
like normal cells of the same type. Grade 3 and 4 tumors tend to
grow rapidly and spread faster than tumors with a lower grade.
10. Diagnostic tests to ID cancer
Routine screening
Mammogram
Colonoscopy
PAP Smear
Others not as established – Lung CT, Specific blood
tests
Issues are often r/t cost, insurance coverage, controversy
See ACS website for complete list of screening guidelines
12. Diagnostic tests to ID cancer
Labs
CBC, Chem Panel, Liver studies
Some cancer specific tests, called tumor markers (PSA, CA 125,
CEA, etc)
Genetic markers – (BRCA, etc)
Diagnostic tests
Imaging – Ultrasound, CT, MRI, PET CT, Endoscopy, Radio-
isotope scans
Often biopsy done with Imaging guidance
Often require a series of tests, and the entire time, the
patient is anxiously waiting!
13.
14.
15. Biopsy
Definitive identification of histological type of cancer
Determines type of treatment necessary
Role of Tumor Board
Role of Clinical Trials
16. Tumor Board
Group meets, usually weekly
MDs - Radiologist, Pathologists, Medical Oncologists,
Surgeons, Radiation Oncologists, Geneticists, Psychiatrists,
Palliative Care, Hospice, Primary Care
Psychologists, Social workers, Nurse Navigators, Infusion
Room nurses, Radiation Therapy staff and nurses,
Nutrition, Physical and Occupational Therapy, Surgical
and Oncology nurses, Research nurses, Cancer Registry
staff
Others: Medical and Nursing Students – have to sign
confidentiality agreement
If you get a chance to go, do it! Fascinating stuff!
17. Tumor Board
Present all Imaging results
Present all lab results, including biopsy
Present patient’s H & P
Compare to National standards and guidelines
Discuss cancer and best therapy for that patient
Recommend treatment options, including clinical
trials and referrals to other facilities (UCSF, Stanford)
ALL participants discuss, all cite evidence and research
Often lively discussion and debate about
recommendations
18. Clinical Trials
Variety of trials available – prevention, screening,
diagnostic, treatment, QOL, genetics
Patient may leave clinical trial at any time
Some trials have been stopped abruptly
Significant negative outcomes
Significant positive outcomes
Nurse has huge role in Clinical Trials
Assisting people in finding appropriate trial
Data collection and monitoring
Clinical follow-up
Examples of CT/research in Reno
19.
20. Surgery
Goal – removal of as much of tumor as possible
Other goals:
Placement of treatment devices
Cure
Control
Support/Palliative
Rehab
21.
22. Surgery side effects
Loss of function/motion
Altered body image
Altered sexuality
Social isolation
Infection
23. Chemotherapy
Huge number of chemicals that we can give to people –
more being developed all the time.
Cure
Control
Support/palliative
24. Types of chemo administration
Oral
IV – most common today
Usually given in cycles, sometimes RTC
Peripheral
Central
Intracavity or into organ
Intrathecal or into ventricles
25. Issues r/t chemo
Toxicity
Patient
Nurse safety
Side effects
Long therapies
Cycles
Continuous infusions
More and more chemo given in outpatient setting
Chemo in all patient waste for 2-3 days or longer
26. Biologic and Targeted Therapy
Alter or modify the relationship between the host and
tumor
Classic example – hormone therapy for prostate, breast
cancers
Many of the newer targeted therapies are specific for one
type of cancer, or have only been tested with one type of
cancer
Many are still under patent, and quite expensive
Examples:
Gleevec for CML: $6-7K/month for rest of life
Herceptin for breast cancer: $54K/year x 1 year
Patient assistance programs
Patients may reach lifetime maximum of insurance quickly
27.
28. Side effects of chemo
Immediate Skin and nail changes
N&V N & V – up to 2 weeks
Stomatitis, mucousitis after chemo
Fluid shifts Bowel changes
Falls Peripheral neuropathy
Delayed Cognitive changes
Bone marrow
Cachexia
suppression FATIGUE
Alopecia – about 2
weeks after chemo
29. Side effects of chemo
Long term People who had chemo
Infertility as children now are
Cardiac dealing with a variety of
Secondary cancers
issues – need to continue
to see MD for follow-up
Permanent skin and
hair changes Emerging area of study
Some chemos cause
chronic cardiac and/or
pulmonary changes
31. Nausea and vomiting
Much research on this with medications and
complementary therapies
Multiple reasons that people are nauseated/vomit
Anticipatory – “Elevator vomiting”
Immediate
Delayed
Long term
Currently, meds include:
High doses of steroids
Anti-emetics – many specific to cancer therapy
32. Nausea and vomiting
Complementary therapies that have been shown to be
effective:
Acupressure
Acupuncture
Guided imagery
Music therapy
Muscle relaxation
Psychoeducational support and information
Many more are being researched and may show
effectiveness
33. RBCs and WBCs and platelets
RBCs
Transfusions
Erythropoietin
Oxygen
WBCs
GCSF – Granulocyte Colony Stimulating Factor
Often given right after chemo, so that patient never has nadir
Platelets
Transfusion uncommon
Often simply put on bleeding precautions until platelets rise
Meds in the works, so far have not been effective
34. Mouth care
Prevention of mouth sores is crucial for many reasons:
Impaired comfort, Impaired nutrition, Impaired body
image, Impaired communication, Risk for infection and
bleeding to name a few!
Frequent mouth care crucial, but a challenge
Soft toothbrush, no alcohol mouthwash, careful
attention to dentist visits, flossing, avoiding irritating
foods
35. Radiation Therapy
Local
Internal
Brachytherapy
External
Systemic very rarely used
Cure
Control
Support/Palliation
Rehab
36.
37.
38. Side effects of radiation
Immediate
Rare
With head and neck – Skin issues, N&V, mouth sores
Delayed
Usually begin to manifest during treatment to end of
treatment and several weeks beyond
Skin burns, fatigue
GI issues if getting radiation to belly
39. Side effects of radiation
Long term
Chronic fibrous changes in lungs, heart
Prostate – incontinence, impotence
Scar tissue
40. Mitigating side effects
Skin – creams and lotions
Mouth – special rinses and meticulous care
N&V – anti emetics
Fatigue – exercise during and after radiation!
Prostate – Urinary exercises, Kegels, Viagra
41. Combination therapies
Surgery, chemo and radiation may all be used,
sometimes at the same time
These patients are very ill, often with a compounded
bunch of side effects
Biggest risks/concerns:
Infection leading to sepsis
N&V leading to severe dehydration
Anorexia leading to severe malnutrition
Pain from cancer itself, as well as side effects of
treatment
42. Stem cell transplantation/ Bone
marrow transplantation
Used to treat variety of cancers often blood tumors
Patient receives “induction” chemo to eliminate cancer cells
Cells harvested from patient or donor
If patient cells, they are treated to remove any remaining
cancer cells
Patient usually gets more chemotherapy/ sometimes
radiation
Receives stem cells which proliferate and form new cells
that are cancer free
Very intensive process with many risks
Significant long term issues
43.
44. Complementary Therapies
Used with western medicine – best treatments are evidence
based, have had clinical trials
Effective for cancer treatments:
Pet therapy
Healing touch
Music therapy
Support groups
Exercise
Imagery
Ongoing study
Nutrition
Herbal supplements
45.
46. Alternative Therapies
Used instead of western medicine
Hallmarks:
Cash payments
No clinical trials
Often ingredients not revealed
Anecdotal or celebrity evidence
Many of the practitioners do not have hospital privileges
or board certifications, may not be physicians
Doesn’t mean they don’t work, but no data collected
on them – can’t tell if they work or not
47. Advanced Cancers
Diagnosed late – Stage 3 or 4
Usually already have metastasis from primary cancer
Often treatable, can often give significant DFS or PFS
Lance Armstrong – example
Recurrence – originally, was the end
Now, often treatable and can give significant PFS
Some patients on their 3rd or 4th recurrence, related to
aggressive and newer chemos
Secondary cancer
Problem is often that the patient can’t have as much chemo or
radiation – has reached lifetime limit of one or the other or
both, so surgery may be only option available
48.
49.
50. Common cancers and the
treatments commonly used
Lung (p. 560-564) Breast (p. 1311-1326) Lotsa pages!
Leading cause of cancer deaths in Most frequently occurring cancer in
US at present, expected to continue women
to rise for women Screening – mammogram, breast
New screening may diagnosis at exam
earlier stage – improve survival Hallmarks:
Hallmarks: Usually found in screening
Worsening cough with sputum, mammograms, or small lump
weight loss, fatigue, chest pain palpated – usually no symptoms
Treatments include surgery, chemo, Highly treatable, very often curable
sometimes radiation Treatments include surgery, chemo,
Issues include shortness of breath, radiation and hormone therapy
fear and anxiety Issues include fatigue and body
In 2011, @226,000 diagnosed and image
@160,000 died with lung cancer In 2011, @ 288,480 diagnosed,
@40,000 died with breast cancer
51. Common cancers and the
treatments commonly used
Prostate (p. 1386-1391) 5 pages Colon/rectum (p. 1035 - 1038)
Most frequently occurring cancer in Screening test: Colonoscopy, FOBT
men Hallmark:
Screening test Exam, PSA Abdominal pain, change in bowel
Hallmark: Similar to BPH – pattern, blood in stool, anemia
problems urinating or change in Treatment includes surgery,
urination patterns chemotherapy, radiation
Treatment – varies according to Issues include body image, change
stage – sometimes watch and wait in bowel habits, pain
Other treatments include surgery, In 2011, @ 143,000 diagnosed and
radiation, hormonal therapy @51,000 died with colon/rectal
Issues include impotence cancer
incontinence
In 2011, @ 241,000 diagnosed with
and @ 28,000 died with prostate
cancer
52. Common cancers and the
treatments commonly used
Leukemias (p. 694-697) Lymphomas (p. 699-703)
Screening – not done. Screening - not done
Hallmark: fatigue, patient presents Hallmark: Often few symptoms
with infection, has very abnormal until substantial lymph node
labs, esp. WBC involvement. Sometimes patient
Treatments include chemo, rarely presents with infection or chest
radiation, and transplant. pain, and abnormal labs are found.
Some of the new treatments are oral Fever, night sweats and weight loss –
and VERY effective – hold out a lot indicate poorer prognosis.
of promise. Incredibly expensive as Treatments are chemo, radiation
well. and for some, bone marrow or stem
Issues include infections, fear, cell transplants
anxiety and post transplant Issues include fear, anxiety and post
problems transplant problems
In 2011, @ 47,000 diagnosed and In 2011, @79,ooo diagnosed and
23,000 died of leukemias @20,000 died with lymphomas
53.
54. Common cancers and the
treatments commonly used
Multiple Myeloma (p. 703-704) Skin cancers – specifically
Screening – not done Malignant Melanoma (p. 451 – 453)
Hallmark: bone destruction, Screening – annual skin inspection
skeletal pain Other than MM – surgical removal,
One “new” drug is thalidomide – usually not a problem
significant patient education MM – Hallmark – VERY rapid
necessary growth and metastasis
Problems with calcium and uric acid Requires wide excision, lymph node
– may lead to renal failure excision and aggressive
Emphasis on preventing chemotherapy
complications from bone damage Issues with body image, VERY
Issues with pain, fractures difficult treatment (some new
In 2011, @ 21,000 diagnosed,
meds on the way, but cost is
@10,ooo died of multiple myeloma concern)
In 2011, @ 76,000 diagnosed, @9000
died of malignant melanoma
55. Common cancers and the
treatments commonly used
Liver cancer (p. 1086-1087)
Pancreatic cancer (p. 1094-1095)
In the US, rarely a primary site for cancer, Screening not done
in other nations, a common primary site Hallmarks are abdominal pain and
Screening – not done unexplained weight loss, sometimes
jaundice if bile duct blocked
Hallmarks: History of cirrhosis, Hep B
Surgery done sometimes, usually
or Hep C, jaundice, anorexia, nausea, chemo, sometimes radiation for
vomiting palliation
Treatment is directed toward primary Issues include pain, fear
site In 2011, @ 43,000 diagnosed, @
37,000 died with pancreatic cancer –
If liver is primary, surgery, chemo just have not made a lot of headway
transplantation sometimes an option on this cancer yet, because the
New technique of radiofrequency and/ cancer has often metastasized by
the time of diagnosis
or chemoablation may be more effective
Issues include pain, fear
In 2011, @ 28,000 were diagnosed and
@20,000 died with Liver cancer
56. Complications of cancer
Nutritional issues
Infections
Cancer emergencies
Pain
Skin Integrity
Financial
57. Nutritional issues
Some cancers and some Some cancers are treated
treatments are hard on the with high doses of steroids
GI system that make a person
People often need more REALLY hungry, and they
nutrition during and after gain water and food weight
treatment, but they are not during treatment. They
hungry, don’t want to cook get bloated, striae, and feel
or eat. lousy.
Nutritional supplements They need to eat healthy
necessary, sometimes G frequent small meals, with
tubes even. an emphasis on high
nutrition and low salt.
Right.
58. Infections
We create new openings:
Surgical sites
IV sites
We give meds/treatments that decrease the immune
response
We give meds/treatments that may mask symptoms of
infection
These are people who have a fever of 100.5, feel lousy
and turn out to be septic.
End up in hospital on IV broad spectrum antibiotics.
59. Cancer Emergencies
There are many of these – I do a whole 2 hour lecture
on them, if you would like to see it.
Suffice to say, most need to be addressed immediately,
and vary with the type of cancer and the type of
treatment.
Oncology nurses and doctors will give patients
information about the ones for which they are at
highest risk. Patients need to CALL if they have these
symptoms.
60. Cancer Emergencies – a few
Malignant pleural effusion
Cardiac tamponade
Superior vena cava syndrome
Bone metastases and fractures
Spinal cord compression
Increased intracranial pressure
DVTs
61. Pain
Cancer pain is no different than other pain IMHO – it
is just more persistent and feared
Related to either cancer itself occupying space, or
rubbing against something, or treatment side effects
Very treatable with appropriate methods
ATC meds are the best for some pain BUT!
Examples:
Surgery, chemo and radiation all can be used to reduce
pain
Pains specialists can be called in to do nerve blocks,
ablations to reduce pain
62. Skin integrity
Serious concern, as any open lesions predispose for
infection
Many treatments dry skin out (some chemos), damage
hair and nails (chemo) and may cause nerve damage,
decreasing the ability to feel
Radiation may cause skin damage, and although it is
temporary, it can be very problematic
Skin folds, pannus, neck, mouth, face, perineum –
breakdown is a serious problem
May need wound consult
63. Financial
People without insurance
Limited options for treatment
Depend on charity
Meds may be donated by drug companies
Patient may choose not to have treatment at all
People with insurance
May need to continue working to keep insurance
Co pays and deductibles may be very high
Billing very confusing at best!
Insurance may refuse some treatments, need to appeal
Insurance may have cap on treatment costs
Other costs – non-reimbursable
Time off work
Travel
Meals out
What else?
Many people, even with insurance, end up declaring medical bankruptcy
Try getting individual policy type life insurance after having had cancer – not
happening
64. Psychosocial impact of cancer
Fear
Pain
Death
Long treatment regimen
Unknown
Coping mechanisms
Support groups
Navigators
Cancer Survival Toolbox/Stress thermometer
Entire family needs assistance, not just patient
65. Fear
Diagnosis of cancer very stressful for patient and family
Often comes at the end of several stressful weeks of
diagnostic tests
Unfamiliar doctors, unfamiliar terms, scary treatments
Radiation
Chemotherapy
Cutting
Cannot promise that treatment will work!
Significant time between beginning and end of treatment,
so chronic stressor
66. Fear of pain
Common concern
Media and others have told of severe, unrelievalbel
cancer pain
Need to address this head on and right away
Need to assess beliefs about pain
Not inevitable
Treatable
Will not make patient an addict
What else?
67. Fear of death
People do die of cancer, no doubt about it
Some cancers are very deadly – which ones did you
identify in this talk?
Need to address this head on as well
Ask questions
Help with advanced directives
Talk about options if needed (Hospice, refusal of
treatment, etc.)
68. Fear of long treatment regimen
Compare with heart attack
Chest pain – go to ER – go to cath lab – go to OR – recovery
and cardiac rehab. First line can all happen within one day.
Breast cancer – get a routine mammo – get called to come
back for more mammos – get called to come back for a biopsy
– go to MD for diagnosis – presented to Tumor Board – have a
lumpectomy – wait for results – go to oncologist – discuss
treatment options – start treatment. Treatment may take up
to 4 months for chemo, then 2 months for radiation, with a
month off in between. So all of the above can take over a year!
At which point the oncologist says “Well it’s all gone, so we
are good for now. Come back and see me in 3 months.”
69. Fear of unknown
How many words have I used so far today that were
new to you?
You don’t have cancer!
Think how hard it would be to hear these words if you
were also dealing with a new diagnosis!
No wonder that people say “The doctor didn’t tell me
anything.” What they meant was “I didn’t hear
anything.”
70. Coping – Support Groups
Research and surveys have indicated that this is VERY
helpful for some people
Some people find on-line groups better than face-to-
face, or that may be only choice for some
Caregiver support groups are very beneficial as well, to
help family and loved ones cope with the changes that
cancer, its treatment and its ramifications bring
Usually led by a nurse or social worker, to guide group
and make sure information is accurate
71. Coping - Navigators
Research and surveys indicate that patients with
navigation are seen faster, more likely to complete
treatment and more satisfied with their experience
than others.
Issues:
Navigators do not generate revenue for hospitals, and
may in fact cost money
Hard to quantify the work
Probably will be required in the future to get
accreditation by American College of Surgeons and
other groups
72. Coping – Cancer Survival Toolbox
Series of CDs or downloadable talks that address the
common issues that cancer patients and their families
experience
Developed by Oncology Nurses and Oncology Social
Workers
Highly regarded by professional groups as helpful and
accurate
Currently developing more on specific cancers
Go to web site!
73. Coping – Stress Thermometer
See handouts
Great tool to quickly ID issues and or problems that
you can address each visit
Monitor whether things are getting better or worse
Clearly indicates (if you use and follow through!) that
you know how stressful the cancer treatment is
Provides you with suggestions for referrals
Fact G sheet – similar tool, but takes longer
74. Fact-G Use and Referral Guidelines for Nurse Navigators
All Cancer Center patients have FACT-G completed
w/in 2 mos of initial contact w Nurse Navigator
Physical Social/Family Emotional Functional
T Score >50 T Score >50 T Score >50 T Score >50
No referral required No referral required No referral required No referral required
T Score <50 T Score <50 T Score <50 T Score <50
Nurse Navigator assesses specific issues contributing to low score
Intensify Nurse Intensify Nurse
Navigator contact Navigator contact
Referral if appropriate to:
Referral if appropriate to: Referral if appropriate to:
Referral if appropriate to: • Med Onc / Rad Onc for
• Med Onc / Rad Onc for • Support Groups
• Support Groups symptom mgmt
symptom mgmt • Individual Counseling
• Individual Counseling • PT / Cancer Rehab for
• PT / Cancer Rehab for • Spiritual Care
• Spiritual Care functional issues
fatigue •Physician if medication
• Financial Counseling • Nutrition if related to issues
• Nutrition if related to issues possibly needed
• Support groups
Repeat FACT-G w/in 1 month end of tx and at 6 mos post-tx if contact continues
Draft 8/9/11 Powerpoint Presentations – Flowchart Fact-G Use
75. Psychosocial impact of cancer
Family issues
Patient advocacy
Lifestyle changes
Valley of the Shadow of Death
76. Family issues
Guilt, blame, shame
Body image changes affect the whole family
Role changes within the family may be significant
Not unusual to have a family member not able to deal
with diagnosis
Can bring some family conflicts to the forefront,
especially related to end of life issues
77. Patient advocacy
Nurses need to advocate for patients:
Physicians
Pharmacy
Insurance
Sometimes family!
Sometimes employers
Tale of two breast cancer patients
“What can we do for Kelly.”
“Take all the time you want – you’re fired.”
78. Lifestyle changes
Examples:
Patient who scuba dives + new colostomy
Patient with breast cancer + clothes don’t fit
Patient with pancreatic cancer + well meaning friends
who suggest alternative therapy
Patient who is newly married + prostate cancer and
possible impotence
Patient with stem cell transplant who needs to live in a
very clean environment + has chickens he loves (Has to
get rid of them)
79. Valley of the Shadow of Death
We take people, some of whom have few or no
symptoms, and put them through a terrible ordeal. It
is truly amazing that they usually trust us!
You have seen, or will see, people in the hospital with
terrible complications from the treatments:
Neutropenia with fever
Awful mouth sores that bleed constantly
Dehydration from ongoing nausea and vomiting or
uncontrollable diarrhea
Malnutrition from anorexia and fatigue
80. Survivorship
Begins the day person is diagnosed
Whole family/group is survivor
http://www.cancer.org/Cancer/News/ExpertVoices/po
st/2012/06/14/ACS-releases-new-data-on-
survivorship.aspx
81. Death and Cancer
Still kills a lot of folks.
However:
Cancer gives you time
Usually we can give you wide awake, alert pain-free
quality time
Opportunity for spiritual growth
82. So why be a cancer nurse?
Always changing, new info
Improvements every day in care
Research opportunities
Autonomy of practice
People teach you how to live/how to die – personal
growth
Advanced degrees, certifications
83.
84. Emerging issues
Genetic testing
Survivorship – beyond 5 years
Mitigation of risk factors – ex. Gardisil
Increasing use of aggressive regimens, especially on
elders
When to stop – 1st recurrence? 2nd recurrence? 3rd
recurrence?
Some cancer becoming chronic illnesses
Incredible cost of care, especially new drugs
85.
86. Sources of reliable information
American Cancer Society http://www.cancer.org/
American Society of Clinical Oncology
http://www.asco.org/
Oncology Nursing Society - research and evidence based
guidelines for nursing care http://www.ons.org/
National Cancer Institute http://www.cancer.gov/
National Coalition of Cancer Survivorship
http://www.canceradvocacy.org/
National Comprehensive Cancer Network – guidelines for
all types of cancer – updated at least yearly
http://www.nccn.com/