Microneedling

1. THE MORPHEUS8 PLATFORM IS THE FIRST AND ONLY FDA
CLEARED DEVICE TO DELIVER SUBDERMAL ADIPOSE TISSUE
REMODELLING TO 8MM – THE DEEPEST FRACTIONAL
TREATMENT AVAILABLE.
• Body remodelling continues to be among the highest sought
after aesthetic procedures. In the majority of cases,
consumers are seeking to enhance body shape without
surgical intervention or downtime.
• From the RF fractional market leader InMode, comes a new stand-
alone platform delivering Full Body Fractional Remodelling.
• Penetrating subdermal tissue up to 8mm (7mm + 1mm thermal
profile), the new Morpheus8 platform takes fractional
radiofrequency to depths beyond anything else available in the
market.

2. MORPHEUS8 - RADIOFREQUENCY SARD - HOW IT WORKS
 Energy is applied between needle and external electrode placed on the skin surface
 Triple action:
 Ablation
 Fat Coagulation
 Volumetric bulk heating
 Large volume of tissue is effected
 Large contraction zone
 Full thickness sub-necrotic heating
 Treated tissue
 Epidermis
 Dermis
 Sub-cutaneous adipose

3. Morpheus8 SCIENCE - SUPERIOR vs OTHER TECHNOLOGIES
• Morpheus8 delivery is advanced, superior, and diverse
• Broad spectrum dermal heating is closed-looped

4. Morpheus8 - Coagulation zone around the Micro pins
Energy level: 5
Coagulation: 750um
Area coverage: 4.7%
Energy level: 20
Coagulation: 1060um
Area coverage: 9.5%
Energy level: 40
Coagulation: 1260um
Area coverage: 13.4%
Energy level: 60
Coagulation: 1400um
Area coverage: 16.4%
Coagulation Zone Calculation
• RF energy distribution around the needle were computerized
• Coagulation zone was calculated as volume where temperature is above 50oC in the end of the RF pulse
• Needle diameter: 250um
• Uncoated tip length: 0.5mm

5. Morpheus8 Body - Burst modality
Three step RF vulcanisation Process:
1. CHARGE - Powerful RF energy burst delivered deep into
the FSN causing re-orientation of collagen fibers
2. MOLD - RF energy dissipation leads to block heating
resulting in collagen remodelling and buttressing of FSN
3. WEAVE - RF energy delivered to the dermal level causing
pulling and synching of fibers into a weave

6. Difference between Morpheus8 and Micro Needling
MICRO NEEDLING
• Bipolar RF energy is applied between needles and
external electrode
• Energy is applied between needles
• Lower density of the needles reduces mechanical
damage and allows more thermal effect
• High frequency of the needles results in more
mechanical and less thermal damage
• Higher penetration depth • Lower penetration depth
• Strong bulk heating • No bulk heating
• 5 times higher energy/needle • Low energy/needle
• Single treatment results • Multiple treatments required
• Optimized for
• Body treatment
• Facial treatment
• Periorbital treatment
• Skin resurfacing
• Designed for facial treatment
• Adjustable Multi-pulse Modes (BURST) • Single pulse mode

7. Morpheus8 , Thermage FLX & Ultherapy
Morpheus 8 Thermage FLX Ultherapy
Technology Bipolar Radio Frequency Monopolar Radiofrequency Ultrasound
Duration 30 minutes 90 minutes 90 - 120 minutes
The level of Pain Moderate Pain (with heat) Moderate Pain (with heat) Moderate Pain (with heat)
Cost For Full Face
Treatment In A year
$108 x 3 Treatments = $324 900 Shots = $1100 840 Shots = $833
Treatment Price $2500-$3000 $2800-$3000 $2200-$2500
Penetration Depth 24 Pins = 0.5 - 4mm + 1mm Bulk Heating
40 Pins = 2mm-7mm + 1 mm Bulk Heating
4.3mm 1.5mm, 3.0mm & 4.5mm
Indication Skin Tightening
Active Acne, Acne Scarring
Pore Size, Fine Lines, Wrinkles, Stretch Mark
Fat Tissue Remodelling
Upper Eyelid Laxity & Lower Eye Bag
Reduction
Skin Tightening Skin Tightening
Frequency Of Treatment &
Longevity
Three times or more:
The effects last more than a year.
One time treatment:
The effects last about 1 year
One time treatment:
The effects last about 1 year

8. The Morpheus8 Tip is in a box of 4 sterile packs and single use only

9. Comparing Morpheus8 Tips
Morpheus8 Morpheus8 resurfacing Morpheus8 prime Morpheus8 body
Length 1mm - 4 mm Length 0.5mm Length 1mm - 4 mm Length 2mm - 7 mm
Additional 1mm heat profile Additional 0.25mm heat
Profile
Additional 1mm heat profile Additional 1mm heat profile
24 micro pins 24 micro pins 12 micro pins 40 micro pins
Computerized Treatment
Depth
Fixed Length Computerized Treatment Depth Computerized Treatment
Depth
Isolated with 0.5mm
Conductive Tip
0.5mm Conductive Tip Isolated with 0.5mm
Conductive Tip
Isolated with 0.5mm
Conductive Tip
1-3 Sessions 3-6 Sessions 1-3 Sessions 1-3 Sessions
Subdermal and
dermal remodelling of facial
areas such as cheeks,
nasolabial folds, neck, and
jowls and through
fractional coagulation and sub-
necrotic bulk heating
Epidermal resurfacing of the
superficial layer of the skin
Subdermal and
dermal remodelling of small
hard-to-reach areas such as
the preorbital area, forehead,
inner arms, and delicate female
region through fractional
coagulation and sub-necrotic
bulk heating
Subdermal and
dermal remodelling of larger
body areas such as the
abdomen, thighs, and
buttocks, through fractional
coagulation and sub-necrotic
bulk heating

10. Before & After Morpheus8

11. CLINICAL PAPERS

12. Plume Effect of Fractional Radiofrequency Versus Laser Resurfacing:
Considerations in the COVID-19 Pandemic
LASERS IN SURGERY AND MEDICINE
The COVID‐19 pandemic requires us all to re‐evaluate aesthetic practices to ensure optimal
patient safety during elective procedures. Specifically, energy based devices and lasers
require special consideration, as they may emit plume which has been shown to contain
tissue debris and aerosolized biological materials. Prior studies have shown transmission of
viruses and bacteria via plume (i.e., HIV and papillomavirus). The purpose of this study was
to evaluate plume characteristics of the Er:YAG resurfacing laser (Sciton; Palo Alto, CA) and
compare it to the Morpheus8 fractional radiofrequency device (InMode; Lake Forest, CA).
Five patients who underwent aesthetic resurfacing and/or skin tightening of the face and
neck were treated with the Er:YAG (Sciton Joule, Palo Alto, CA) and/or fractional
radiofrequency (Morpheus8, Lake Forest, CA). Patients were evaluated during treatment
with a calibrated particle meter (PCE; Jupiter, FL). The particle meter was used at a
consistent focal distance (612 inches) to sample the surrounding environment during
treatment at 2.83 L/min to a counting efficiency of 50% at 0.3 μm and 100% at >0.45 μm.
Recordings were obtained with and without a smoke evacuator. Results demonstrated that
the Er:YAG resurfacing laser emits more than four times the particles when compared with
fractional radiofrequency. Fractional radiofrequency treatment did not emit plume
significantly above ambient baseline particle readings of the exam room environment.
Authors: Erez Dayan, MD; Spero Theodorou, MD; Bruce
Katz, MD; and Jeffery S. Dover, MD.

13. Adjustable Depth Fractional Radiofrequency Combined With Bipolar
Radiofrequency: A Minimally Invasive Combination Treatment
AESTHETIC SURGERY Journal
Increasingly, patients are seeking minimally invasive methods to tighten skin and
remodel adipose tissue. A large treatment gap exists among 3 types of patients: (1)
the younger demographic, who increasingly desire soft tissue tightening without
traditional operations, scars, and downtime; (2) patients with soft tissue laxity who
are not “severe enough” to justify an excisional procedure, but not “mild enough” to
rely on liposuction with soft tissue contraction alone; and (3) those with recurrent
laxity who already underwent traditional excisional procedures. In these populations,
plastic surgeons risk under- or overtreating with traditional methods. The purpose of
this supplement is to describe the utility of radiofrequency (RF) microneedling
(Fractora modified to Morpheus8 InMode Aesthetic Solutions, Lake Forest, CA) in
combination with bipolar RF (FaceTite/BodyTite, InMode Aesthetic Solutions). By
combining these procedures, the aforementioned treatment gap can be addressed.
The RF microneedling allows for subdermal adipose remodelling and skin tightening.
Addition of bipolar RF also tightens the skin by contraction of the underlaying
fibroseptal network in addition to induction of neocollagenesis, elastogenesis, and
angiogenesis at skin surface temperatures of 40° to 50°C. In our experience, these
technologies have been effective and safe in these patient populations.
Authors: Erez Dayan, MD; Christopher Chia, MD; and
Spero Theodorou, MD

14. Long Term Follow-up Results of a Fractional Radio Frequency Ablative
Treatment of Acne Vulgaris and Related Acne Scars
Author: Dr. Judith Hellman
Journal of Cosmetics, Dermatological Sciences and Applications
Fractional radiofrequency technologies have been shown to be clinically safe and
effective in managing acne scars through dermal remodelling without causing direct
damage to the epidermis. In a recently published study, we presented our clinical and
histological results in the treatment of patients with active acne and acne related
scarring using a Fractional RF (FRF) device. In the current article we demonstrate long
term follow-up results, up to two years post last fractional treatment.
Methods: Four out of the eight patients who completed a four treatment regimen were
invited for long term follow-up visit to document treatment results. In some cases,
touch-up treatments were conducted to optimize clinical results.
Results: Patients demonstrated significant improvement of acne lesions, acne scarring,
pores and skin texture. Long term photos demonstrated that clinical improvement
progressed with time.
Conclusion: The current study further supports the previous findings that FRF is a safe
and effective treatment modality for active acne and acne related scars. Treatment
protocol can be customized according to patient needs and clinical results last for long
term.

15. Facial skin rejuvenation by combination treatment of IPL followed by
continuous and fractional radiofrequency
Journal of Cosmetic & Laser Therapy
Objective: The objective of this study was to evaluate the safety and efficacy of
combination facial treatment by 3 technologies.
Materials and methods: Eleven patients completed the clinical trial that
consisted of alternate treatments of intense pulsed light (IPL) in 3 sessions and
continuous fractional bipolar radiofrequency (RF) in 3 alternating sessions, 3
weeks apart. Follow-up visits were made at 6 and 12 weeks following the last
treatment. Lesions were evaluated by photographs taken at baseline and at
follow-up time points according to predetermined scales.
Results: Results showed statistically significant improvement in wrinkling,
pigmentation, vascular lesions, and laxity.
Conclusions: Combination facial treatment by IPL, and continuous and
fractional RF is safe and enables the treatment of a variety of facial lesions,
taking advantage of accessible applicators for different clinical indications on
the same device. Thus, comprehensive facial skin rejuvenation has become
feasible.
Authors: Michael H. Gold, MD, Julie A. Biron, MD, &
Whitney Sensing, MD

16. Fractional Ablative Radio-Frequency Resurfacing in Asian and Caucasian
Skin: A Novel Method for Deep Radiofrequency Fractional Skin Rejuvenation
Journal of Cosmetics, Dermatological Sciences and Applications
This paper reports the clinical experience of a multi-center, multiple
physician trial with a novel fractional radio-frequency ablative skin
resurfacing and rejuvenation device (Fractora, Invasix, Israel) deployed on
both Caucasian skin types I – III and Asian skin type IV. Histological study
demonstrated deep ablation and collagen restructuring in the papillary
and reticular dermis. The Fractora device combines the more “cone
shaped” ablation seen with CO2 and Erbium lasers with a deep non-
ablative heating pattern, seen with other bipolar RF fractional needle
resurfacing devices. Ablation, coagulation zones and healing dynamics are
analyzed for different energy settings. Two different treatment protocols
are suggested: one for light skin and then one for darker skin with a higher
risk of post-inflammatory hyper-pigmentation. Treatment results show
improvement in skin texture, pores, wrinkles and skin dyschromia.
Authors: D. H. Ahn, S. Mulholland, M. Kreindel, M. Paul

17. Morpheus8 on Social Media & TV Shows

18. MORPHEUS8 on social media - Influencers
Kim Kardashian
202m Followers
Stephanie
Shepherd Suganami
1.6M Followers
Victoria Fuller
569K Followers
Iggy Azalea
14.4M Followers

19. Morpheus8 Direct Consumer Campaign

20. VERSATILITY
AT YOUR
FINGERTIPS

21. THANK YOU