Short introduction Definition Theorieses of aging causes of aging life span Aging can be defined as the time related deterioration of the physiological functions necessary for survival . Or Can be define as increase in impairment in Physiological functions with age , Increased in suspectebility to diseases and decrease in ability of fertility aging is the impact of time on the human body, and it occurs on multiple levels: Cellular changes Extracellular changes 1) cellular changes Causes of aging Cellular senescence and aging Telomere shortening: linked to life expectancy and aging Mitochondrial dysfunction and aging Oxidative stress Stem cell exhaustion Developmental biology by T.subramonium Developmental biology 6th edition

1. AGING
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Presentation by,
Somnath
kalidas kamble
MSc Part 1
Roll no - 06

2. CONTENTS
1. Short introduction
2. Definition
3. Theorieses of aging
4. causes of aging
5. life span
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3. STAGES OF HUMAN LIFE CYCLE
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AGING

4. WHAT IS AGING ?
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• Aging can be defined as the time related
deterioration of the physiological
functions necessary for survival .
Or
• Can be define as increase in impairment in
Physiological functions with age , Increased
in suspectebility to diseases and decrease in
ability of fertility

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6. THEORIES ASSOCIATED
WITH AGING
1. Genetic theory
2. Nongenetic theories
3. wear-and-tear theory
4. Cross-linking theory
5. Oxidative damage theory
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7. CHANGES ASSOCIATED WITH
AGING
• aging is the impact of time on the human
body, and it occurs on multiple levels:
1. Cellular changes
2. Extracellular changes
1) cellular changes –
a) Telomere shortening:
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8. • Enzymes changes
• Accumalation of aging pigments
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9. EXTRACELLULAR
CHANGES
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• The changes Occuring in the Intracellular
Spaces and lumen of blood Vascular system
are the example of extracellular changes
• Dementia
• Alzheimer's
• Progeria
• Parkinson’s
disease

10. CAUSES OF AGING
1. Cellular senescence and aging
2. Telomere shortening: linked to life expectancy and aging
3. Mitochondrial dysfunction and aging
4. Oxidative stress
5. Stem cell exhaustion:
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11. LIFE SPAN
• The maximum life span is a characteristic of the species.
• It is the maximum number of years a member of that species has
been known to survive.
• The maximum human life span is estimated to be 121 years
• he life spans of tortoises and lake trout are both unknown, but are
estimated to be more than 150 years.
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12. THANK YOU
• Reference
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• Developmental biology by T.subramonium
• Developmental biology 6th edition