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Prediktiv
Prosessering
hjernen syr sammen
en mening basert på
indre modeller (priors)
tilgjengelig sanseinformasjon
hvis hypotesen
ikke stemmer
prediksjonsfeil
diskrepans mellom
forventning og realitet
affekt
ambivalens
uforutsigbarhet
hvis uavklart
vedvarende symptomer?
@SigMik
OVERLEVELSE ENERGI-
ØKONOMISERING
HJERNENS
FUNKSJON
PREDIKTIV
PROSESSERING
kroppslig & mental helse
adferd, kognisjon,
persepsjon, handling
Rigget for
overlevelse
Indre modeller
- medfødte
- innlærte
Free Energy Principle
Hjernen bruker mye energi
1. Hjernen er reaktiv og fungerer
som et refleksorgan?
2. Hjernen er proaktiv og fungerer
som et prediksjonsorgan?
Stemmer
forventningen?
Free Energy Principle
Hjernen bruker mye energi
1. Hjernen er reaktiv og fungerer
som et refleksorgan?
2. Hjernen er proaktiv og fungerer
som et prediksjonsorgan?
Stemmer
forventningen?
10% av synapsene til synsbarken bærer informasjon fra retina.
Sherman & Guillery 2002 – The role of the thalamus in the flow of information to the cortex
Hjernen bruker MYE mer energi på å predikere
enn å håndtere innkommende sanseinformasjon!
10 x flere synapser fra synsbarken til talamus.
Prediktiv
Prosessering
indre modeller
sanseinformasjon
+
=
prediksjonsfeil
Hvordan endre prediksjonsfeil:
1) oppdatere indre modell
2) påvirke måten man innhenter
sanseinformasjon
til å stole på
Sansene
er ikke
fordi det er for
mye å ta inn
Barrett & Simmons 2015 – Interoceptive predictions in the brain
Presisjonsvekting
av prediksjonsfeil
Glutamat ↑
GABA ↓
Dopamin ☆
Den Bayesianske Hjernen
(sannsynlighetsberegning basert på
medfødte og innlærte indre modeller)
Presisjonsvekting
av hypoteser
indre modeller
sanseinformasjon
e
f
f
e
r
e
n
t
f
e
e
d
f
o
r
w
a
r
d
a
f
f
e
r
e
n
t
f
e
e
d
b
a
c
k
biologiske script
erfaringer
narrativ
eksterosepsjon
interosepsjon
nevrosepsjon
uavklart = PREDIKSJONSFEIL
dysregulering
av homeostase
når det
går galt
Integrerings-
kapasitet
Petzschner et al 2017
Alt som truer
eksistensiell og
kroppslig integritet
Genetikk
Tidlige leveår
Senere leveår
dysregulering
av homeostase
sårbarhet
robusthet
næring
tæring
Daskalakis et al 2013
Three hit concept of vulnerability and resilience
Genetikk
Tidlige leveår
Senere leveår
Descalzi et al 2017 - Neuropathic pain promotes
adaptive changes in gene expression in brain
networks involved in stress and depression
N
E I
SAMME
SYSTEM
kroppen OG toppen
Genetikk
Tidlige leveår
Senere leveår
Chapman et al 2008
Stress and pain in a systems perspective
transversus abdominis
muscle tuning
traumer
dissosiasjon
kroppsskjema
aleksitymi
depresjon
angst
Kohnstamm-fenomenet
symptomrapportering
emosjoner
generalisering
Grand
Unifying
Theory
?
placebo
nocebo
mening-respons
smerte
Up for grabs?

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Prediktiv prosessering og den Bayesianske hjernen.pdf