1. Retinal Protective Effects of Resveratrol via Modulation of Nitric Oxide Synthase on Oxygen-induced Retinopathy. Molecular Biology Sneider A. Torres Soto School of medicine

2. INTRODUCTION The Retinopathy of prematurity (ROP) is a disease that affects immature vasculature in the eyes of premature babies.

3. INTRODUCTION The resveratrol is a phytoalexin produced by a variety of plants such as grapes, peanuts, and berries in response to stress, injury, ultraviolet irradiation,and fungal infection.

4. INTRODUCTION The resveratrol is a stimulation of NO production in endothelial cells to exert vasodilatory effect on blood vessels. The NO Sintase are a family of eukaryotic enzymes that catalyze the production of nitric oxide (NO) from L-arginine.

5. GENERAL OBJETIVE Determine the protective effect of resveratrol in premature retinopathy.

14. Grupo N ninguna patologia.

15. Grupo H neovascularizacion retiniana, crecimiento fibrovascular, desprendimiento de retina

18. RESULTADOS Viabilidad celular en el modelo in vitro. Ensayo de MMT determina la concentración optima de resveratrol (5ug/ml).

21. RESULTADOS

23. DISCUSSION

24. CONCLUSIONS The resveratrol is a important compound in the premature retinophaty. Should continue investigating the effects of resveratrol in various pathologies.

25. CONCLUSIONS To do a good dosage of oxygen therapy to prevent this disease. Proper use of animal models can still provide great advances in modern medicine.

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