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Editor-in-Chief
Kevin A. Roth, Columbia University College of Physicians and Surgeons
Senior Associate Editor
Martha B. Furie, Stony Brook University
Senior Assistant Editor
Robin G. Lorenz, University of Alabama at Birmingham
Associate Editors
Chris Albanese, Georgetown University Medical Center
Steven L. Carroll, Medical University of South Carolina
William B. Coleman, University of North Carolina Chapel Hill
Zoran Culig, Medical University of Innsbruck
Patricia A. D’Amore, Schepens Eye Research Institute d Massachusetts Eye and Ear
Lora Hedrick Ellenson, Cornell University
Philippe G. Frank, The University of Tours
Philip Furmanski, Rutgers University
Nisha Jain Garg, University of Texas Medical Branch
Michael S. Goligorsky, New York Medical College
Meera Hameed, Memorial Sloan-Kettering Cancer Center
David M. Hockenbery, Fred Hutchinson Cancer Research Center
Yoshifumi Itoh, University of Oxford
Christopher G. Kevil, Louisiana State University Health Sciences Center
Andrew A. Lackner, Tulane University
Satdarshan (Paul) Singh Monga, University of Pittsburgh School of Medicine
David J. Nikolic-Paterson, Monash Medical Center
William C. Parks, Cedars-Sinai Medical Center
Charles A. Parkos, University of Michigan
Drucilla Roberts, Massachusetts General Hospital
Shin’ichi Takeda, National Center of Neurology and Psychiatry
Jouni Uitto, Thomas Jefferson University
Xiao-Ming Yin, Indiana University School of Medicine
Dani S. Zander, Penn State Milton S. Hershey Medical Center
Managing Editor
Audra E. Cox, PhD, ELS
Assistant Managing Editor
Emily H. Essex
Production Editor
Henry L. Carter, Jr.
Scientific Editor
Chhavi Chauhan, PhD, ELS
Editorial Assistants
Michael Dustin (Sr.), Dia Pellerin, Angela L. Schmeckebier (Birmingham)
The official journal of the American Society for
Investigative Pathology, published by Elsevier,
Inc., seeks to publish high-quality, original
papers on the cellular and molecular biology
of disease. The editors accept manuscripts that
advance basic and translational knowledge of
the pathogenesis, classification, diagnosis, and
mechanisms of disease, without preference
for a specific analytic method. High priority
is given to studies on human disease and
relevant experimental models using cellular,
molecular, animal, biological, chemical, and
immunological approaches in conjunction
with morphology.
http://ajp.amjpathol.org
Editorial Board
Sarki A. Abdulkadir
Malcolm Alison
Charles E. Alpers
Gianfranco Alpini
Kenneth E. Bernstein
Generoso Bevilacqua
Gloria Bonuccelli
Jeffrey A. Boyd
Arnold R. Brody
Bruno Calabretta
Franco Capozza
Mathew C. Casimiro
Vincent Castronovo
Wing (John) Chan
John C. Chatham
Erika Cione
Robert B. Clarke
Paolo M. Comoglio
Mark T. Curtis
Robert D’Amato
Abhijit Dasgupta
George S. Deepe, Jr.
Francesco Del Galdo
Dolores Di Vizio
Wen-Xing Ding
Jocelyn Dupuis
David M. Engman
Motomi Enomoto-Iwamoto
Ozlem Er
Stephen M. Factor
Melanie B. Feany
Thomas J. Flotte
Agnes Fogo
Michael L. Freeman
Michael R. Freeman
Matthew P. Frosch
Kevin L. Gardner
Elisabetta Gazzerro
Godfrey S. Getz
Andrew Gewirtz
Jeffrey A. Golden
Leonard G. Gomella
Steven Gonias
Avrum I. Gotlieb
Kevan L. Hartshorn
Mary J.C. Hendrix
Eric P. Hoffman
Jeffrey C. Horowitz
Anton J. Horrevoets
Anthony Howell
Nicholas H. Hunt
Lorraine Iacovitti
Renato V. Iozzo
Elaine S. Jaffe
Jean-Franc¸ois Jasmin
Sanjay Katiyar
C. Dirk Keene
Dontcho Kerjaschki
Karen E. Knudsen
Olivier Kocher
Laurie T. Krug
Rakesh K. Kumar
Hans Lassmann
William Lewis
Shengwen Li
Megan S. Lim
Michael P. Lisanti
Ricardo V. Lloyd
Massimo Loda
Nicholas W. Lukacs
James W. Mandell
Yves L. Marcel
Ubaldo Martinez-Outschoorn
Peter A. McCue
Jay M. McDonald
Steven B. McMahon
Isabelle Mercier
David K. Meyerholz
Kohei Miyazono
Carlos S. Moreno
George F. Murphy
Ruth J. Muschel
Asma Nusrat
Shuji Ogino
Yasunori Okada
Tristrim Parslow
Mercio A. PereiraPerrin
Yuri Persidsky
Sem H. Phan
Liise-anne Pirofski
Michael B. Prystowsky
Andrew A. Quong
Janardan K. Reddy
Raju C. Reddy
Daniel Remick
David L. Rimm
Natalia A. Riobo
Charles L. Rosen
Abdolmohamad Rostami
Hallgeir Rui
David B. Sacks
Jeffrey E. Saffitz
David S. Salomon
Samuel A. Santoro
Philipp E. Scherer
Eveline E. Schneeberger
Darryl Shibata
Gene P. Siegal
Keith R. Solomon
Federica Sotgia
David C. Spray
Patricia S. Steeg
William G. Stetler-Stevenson
David S. Strayer
Gary E. Striker
Herbert B. Tanowitz
Victor J. Thannickal
Peter Tipping
Warren G. Tourtellotte
Jerrold R. Turner
Matt van de Rijn
David H. Walker
Chenguang Wang
Karen E. Weck
Louis M. Weiss
Alan Wells
Anthony Whetton
Elizabeth M. Whitley
Monte S. Willis
Agnieszka K. Witkiewicz
T.C. Wu
Tesshi Yamada
David Zagzag
Federico Zara
Jianhua Zhang
Jing Zhang
The American Society for
Investigative Pathology
EXECUTIVE OFFICER: Mark E. Sobel
PRESIDENT: William B. Coleman; Past President: Kevin A. Roth; President-Elect: George K. Michalopoulos; Vice President: Daniel
Remick; Secretary-Treasurer: Dani S. Zander; Program Chair: Satdarshan (Paul) Singh Monga; Education Committee Chair: Monte S.
Willis; Committee for Career Development and Diversity Chair: Cecelia Yates; Councilors: Patricia A. D’Amore, Elizabeth M. Whitley;
PUBLICATIONS COMMITTEE: William G. Stetler-Stevenson (Chair), Michelle P. Bendeck, Demetrios T. Braddock, Steven Carroll,
Patricia A. D’Amore (Chair-Elect), Renato V. lozzo, Jacqueline D. Jones-Triche, Morgan Preziosi, Mark E. Sobel, Dani S. Zander
Journal Information
The American Journal of Pathology is published monthly in print (ISSN 0002-9440) and
online (ISSN 1525-2191) for the American Society for Investigative Pathology, Inc. by
Elsevier Inc, 360 Park Ave., New York, NY 10010-1710. Periodicals postage paid at New
York, NY and additional mailing offices.
Business Office: 1600 John F. Kennedy Boulevard, Suite 1800, Philadelphia, PA 19103-
2899. Accounting and Circulation Offices: 3251 Riverport Lane, Maryland Heights, MO
63043. Periodicals postage paid at New York, NY and additional mailing offices.
Postmaster: Send address changes to The American Journal of Pathology, Elsevier
Periodicals Department: 3251 Riverport Lane, Maryland Heights, MO 63043.
Customer Service (orders, claims, online, change of address): Elsevier Periodicals
Customer Service, 3251 Riverport Lane, Maryland Heights, MO 63043. Tel: (800) 654-
2452 (U.S. and Canada); (314) 447-8871 (outside U.S. and Canada). Fax: (314) 447-8029.
E-mail: JournalsCustomerService-usa@elsevier.com (for print support); journalsonline
supportusa@elsevier.com/ (for online support).
Address changes must be submitted four weeks in advance.
Yearly Subscription Rates: Further information on this journal is available from the
Publisher or from this journal’s website (http://ajp.amjpathol.org). Information on other
Elsevier products is available through Elsevier’s website (http://www.elsevier.com).
Advertising Information: Advertising and classified advertising orders and inquiries can
be sent to: Bill Hipple, Elsevier, 360 Park Avenue South, 6th Floor, New York, NY 10010;
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Kelley; phone: 212-633-3198; e-mail: m.kelley@elsevier.com.
Author Inquiries: For inquiries relating to the submission of articles, contact the Editorial
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trackarticle. You are also welcome to contact Customer Support via http://support.
elsevier.com. Please see Information for Authors for individual journal. Contact details for
questions arising after acceptance of an article, especially those relating to proofs, are
provided after registration of an article for publication.
Instructions for Authors can be found online at: http://ajp.amjpathol.org/authorinfo.
Journal Scientific Integrity Policy can be found online at: http://ajp.amjpathol.org/content/
integrity.
The paper used in this publication meets the requirements of ANSI/NISO Z39.48-1992
(Permanence of Paper).
English Language Service: Upon request, Elsevier will direct authors to an agent who
can check and improve the English of their paper (before submission). Please contact
authorsupport@elsevier.com/ for further information.
Reprints: For queries about author offprints, e-mail authorsupport@elsevier.com. To order
100 or more reprints for educational, commercial, or promotional use, contact the
Commercial Reprints Department, Elsevier Inc, 360 Park Ave South, New York, NY
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Ó 2016 American Society for Investigative Pathology. All rights reserved.
This journal and the individual contributions contained in it are protected under copyright
by the American Society for Investigative Pathology, and the following terms and condi-
tions apply to their use:
Photocopying: Single photocopies of single articles may be made for personal use as
allowed by national copyright laws. Permission of the Publisher and payment of a fee is
required for all other photocopying, including multiple or systematic copying, copying for
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AJP board in print 2016

  • 1. Editor-in-Chief Kevin A. Roth, Columbia University College of Physicians and Surgeons Senior Associate Editor Martha B. Furie, Stony Brook University Senior Assistant Editor Robin G. Lorenz, University of Alabama at Birmingham Associate Editors Chris Albanese, Georgetown University Medical Center Steven L. Carroll, Medical University of South Carolina William B. Coleman, University of North Carolina Chapel Hill Zoran Culig, Medical University of Innsbruck Patricia A. D’Amore, Schepens Eye Research Institute d Massachusetts Eye and Ear Lora Hedrick Ellenson, Cornell University Philippe G. Frank, The University of Tours Philip Furmanski, Rutgers University Nisha Jain Garg, University of Texas Medical Branch Michael S. Goligorsky, New York Medical College Meera Hameed, Memorial Sloan-Kettering Cancer Center David M. Hockenbery, Fred Hutchinson Cancer Research Center Yoshifumi Itoh, University of Oxford Christopher G. Kevil, Louisiana State University Health Sciences Center Andrew A. Lackner, Tulane University Satdarshan (Paul) Singh Monga, University of Pittsburgh School of Medicine David J. Nikolic-Paterson, Monash Medical Center William C. Parks, Cedars-Sinai Medical Center Charles A. Parkos, University of Michigan Drucilla Roberts, Massachusetts General Hospital Shin’ichi Takeda, National Center of Neurology and Psychiatry Jouni Uitto, Thomas Jefferson University Xiao-Ming Yin, Indiana University School of Medicine Dani S. Zander, Penn State Milton S. Hershey Medical Center Managing Editor Audra E. Cox, PhD, ELS Assistant Managing Editor Emily H. Essex Production Editor Henry L. Carter, Jr. Scientific Editor Chhavi Chauhan, PhD, ELS Editorial Assistants Michael Dustin (Sr.), Dia Pellerin, Angela L. Schmeckebier (Birmingham) The official journal of the American Society for Investigative Pathology, published by Elsevier, Inc., seeks to publish high-quality, original papers on the cellular and molecular biology of disease. The editors accept manuscripts that advance basic and translational knowledge of the pathogenesis, classification, diagnosis, and mechanisms of disease, without preference for a specific analytic method. High priority is given to studies on human disease and relevant experimental models using cellular, molecular, animal, biological, chemical, and immunological approaches in conjunction with morphology. http://ajp.amjpathol.org Editorial Board Sarki A. Abdulkadir Malcolm Alison Charles E. Alpers Gianfranco Alpini Kenneth E. Bernstein Generoso Bevilacqua Gloria Bonuccelli Jeffrey A. Boyd Arnold R. Brody Bruno Calabretta Franco Capozza Mathew C. Casimiro Vincent Castronovo Wing (John) Chan John C. Chatham Erika Cione Robert B. Clarke Paolo M. Comoglio Mark T. Curtis Robert D’Amato Abhijit Dasgupta George S. Deepe, Jr. Francesco Del Galdo Dolores Di Vizio Wen-Xing Ding Jocelyn Dupuis David M. Engman Motomi Enomoto-Iwamoto Ozlem Er Stephen M. Factor Melanie B. Feany Thomas J. Flotte Agnes Fogo Michael L. Freeman Michael R. Freeman Matthew P. Frosch Kevin L. Gardner Elisabetta Gazzerro Godfrey S. Getz Andrew Gewirtz Jeffrey A. Golden Leonard G. Gomella Steven Gonias Avrum I. Gotlieb Kevan L. Hartshorn Mary J.C. Hendrix Eric P. Hoffman Jeffrey C. Horowitz Anton J. Horrevoets Anthony Howell Nicholas H. Hunt Lorraine Iacovitti Renato V. Iozzo Elaine S. Jaffe Jean-Franc¸ois Jasmin Sanjay Katiyar C. Dirk Keene Dontcho Kerjaschki Karen E. Knudsen Olivier Kocher Laurie T. Krug Rakesh K. Kumar Hans Lassmann William Lewis Shengwen Li Megan S. Lim Michael P. Lisanti Ricardo V. Lloyd Massimo Loda Nicholas W. Lukacs James W. Mandell Yves L. Marcel Ubaldo Martinez-Outschoorn Peter A. McCue Jay M. McDonald Steven B. McMahon Isabelle Mercier David K. Meyerholz Kohei Miyazono Carlos S. Moreno George F. Murphy Ruth J. Muschel Asma Nusrat Shuji Ogino Yasunori Okada Tristrim Parslow Mercio A. PereiraPerrin Yuri Persidsky Sem H. Phan Liise-anne Pirofski Michael B. Prystowsky Andrew A. Quong Janardan K. Reddy Raju C. Reddy Daniel Remick David L. Rimm Natalia A. Riobo Charles L. Rosen Abdolmohamad Rostami Hallgeir Rui David B. Sacks Jeffrey E. Saffitz David S. Salomon Samuel A. Santoro Philipp E. Scherer Eveline E. Schneeberger Darryl Shibata Gene P. Siegal Keith R. Solomon Federica Sotgia David C. Spray Patricia S. Steeg William G. Stetler-Stevenson David S. Strayer Gary E. Striker Herbert B. Tanowitz Victor J. Thannickal Peter Tipping Warren G. Tourtellotte Jerrold R. Turner Matt van de Rijn David H. Walker Chenguang Wang Karen E. Weck Louis M. Weiss Alan Wells Anthony Whetton Elizabeth M. Whitley Monte S. Willis Agnieszka K. Witkiewicz T.C. Wu Tesshi Yamada David Zagzag Federico Zara Jianhua Zhang Jing Zhang The American Society for Investigative Pathology EXECUTIVE OFFICER: Mark E. Sobel PRESIDENT: William B. Coleman; Past President: Kevin A. Roth; President-Elect: George K. Michalopoulos; Vice President: Daniel Remick; Secretary-Treasurer: Dani S. Zander; Program Chair: Satdarshan (Paul) Singh Monga; Education Committee Chair: Monte S. Willis; Committee for Career Development and Diversity Chair: Cecelia Yates; Councilors: Patricia A. D’Amore, Elizabeth M. Whitley; PUBLICATIONS COMMITTEE: William G. Stetler-Stevenson (Chair), Michelle P. Bendeck, Demetrios T. Braddock, Steven Carroll, Patricia A. D’Amore (Chair-Elect), Renato V. lozzo, Jacqueline D. Jones-Triche, Morgan Preziosi, Mark E. Sobel, Dani S. Zander
  • 2. Journal Information The American Journal of Pathology is published monthly in print (ISSN 0002-9440) and online (ISSN 1525-2191) for the American Society for Investigative Pathology, Inc. by Elsevier Inc, 360 Park Ave., New York, NY 10010-1710. Periodicals postage paid at New York, NY and additional mailing offices. Business Office: 1600 John F. Kennedy Boulevard, Suite 1800, Philadelphia, PA 19103- 2899. Accounting and Circulation Offices: 3251 Riverport Lane, Maryland Heights, MO 63043. Periodicals postage paid at New York, NY and additional mailing offices. Postmaster: Send address changes to The American Journal of Pathology, Elsevier Periodicals Department: 3251 Riverport Lane, Maryland Heights, MO 63043. Customer Service (orders, claims, online, change of address): Elsevier Periodicals Customer Service, 3251 Riverport Lane, Maryland Heights, MO 63043. Tel: (800) 654- 2452 (U.S. and Canada); (314) 447-8871 (outside U.S. and Canada). Fax: (314) 447-8029. 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