This document discusses gastro retentive drug delivery systems that can remain in the gastric region for several hours, prolonging the gastric residence time of drugs and improving their bioavailability. Such systems are useful for delivering drugs that are rapidly absorbed in the GI tract, degrade in the colon, or disturb normal colonic microbes, providing examples like metronidazole, tetracycline, ranitidine, metformin, and antibiotics against Helicobacter pylori.

3. • Gastro retentive
systems can remain
in the gastric region
for several hours and
hence significantly
prolong the gastric
residence time of
drugs.
• Prolonged gastric
retention
*improves bioavailability

9. • Drugs which are absorbed rapidly from the GI tract
=>Example: Metronidazole, tetracyline.
• Drugs that degrade in the colon,
=>Example: Ranitidine, Metformim
• Drugs that disturb normal colonic microbes
=>Example: . antibiotics against
Helicobacter pylori.

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