introduction of Depression what is Depressant Anti depressant drugs example 1.Amitriptyline 2. Nor-tryptyline 3. Phenelzine 4. Tranylcypromine 5. Imipramine

1. Anti-depressant drugs
BY : SHAIKH SANIYA

2. Content
 Depression
 Depressant
 Anti depressant drugs
1.Amitriptyline
2. Nor-tryptyline
3. Phenelzine
4. Tranylcypromine
5. Imipramine

3. Depression
 It is a mental illnesses characterized by pathological changes in mood, loss of interest or
pleasure, feelings of guilt or low self-worth, disturbed sleep or appetite, low energy, and
poor concentration .
 It can be severe and some times Fatal.
Types of Depression
1. Major depression
2. Chronic depression
3. Atypical depression
4. Bipolar disorder/Manic depression
5. Seasonal depression

4. What are depressants?
 A depressant, or central
depressant, is a drug that
lowers neurotransmission
levels, which is to depress or
reduce arousal or
stimulation, in various areas
of the brain.
 Depressants are also
occasionally referred to as
"downers" as they lower the
level of arousal when taken.

5. Antidepressants
 Antidepressants are medications used to treat major
depressive disorder, some anxiety disorders, some
chronic pain conditions, and to help manage some
addictions.
 Common side-effects of antidepressants include dry
mouth, weight gain, dizziness, headaches, sexual
dysfunction, and emotional blunting.

6. Antidepressants
1. Drug which enhance alertness and may result in an
increased output of behavior.
2. Potentiate directly or indirectly the action.
3. The purpose of antidepressants is to increase the
neurotransmitters in the synapse.
4. They are used for the relief of symptoms of moderate and
severe depression.
5. Antidepressants are taken for at least 4-6 months.
6. They can be used alone or in combination with other
medications

7. 1.Amitriptyline
 It is tricyclic antidepressant .
Physical properties:
 white crystalline powder or colorless
 Odorless and bitter taste and burring taste causes numbness
 Soluble in water and alcohol.
Stability & storage
 It is affected by air ,hence it is stored in tight closed and light resistant container

8. Uses
 This medication is used to treat mental/mood problems such as depression. It may help
improve mood and feelings of well-being, relieve anxiety and tension, help
you sleep better, and increase your energy level.
Pharmaceutical formulations:
 Amitriptyline injection
 Amitriptyline tablet
Brand name: Amitrip ,Tryptanol

9. 2. Nor-tryptyline
Physical properties:
 white crystalline powder or colorless
 Odorless and bitter taste and burring taste causes numbness
 sparingly Soluble in water.
Uses :
1. Endogenous depression
2. Anxiety
3. Chronic tension headache

10. Pharmaceutical formulations:
 Nor-tryptyline capsule
 Nor-tryptyline tablet
Brand name: Primox, Sensival

11. 3. Phenelzine
 It is phenylethyl hydrazine
 Phenelzine can improve your mood and feelings of well-being.
Physical properties:
 white powder or colorless
 Pungent Odor
 Soluble in water
 Slightly soluble in alcohol

12. Uses
 Anxiety state
 Depressive disorders
 Phobic state
 Obsessive disorder

13. Chemical properties
 When its solution in aqueous NaOH is treated with fehlings solution, a
red precipitated of cuprous oxide is obtained.
Stability & storage
 It is affected by air ,hence it is stored in tight closed and light resistant
container
Pharmaceutical formulations: tablet
Brand name: Nordil

14. 4. Tranylcypromine
Physical properties:
 White crystalline powder
 Odorless
 Soluble in water
 Slightly soluble in alcohol
Stability & storage
 It is affected by air ,hence it is stored in tight closed and light resistant container

15. Chemical properties
 When its suspension in alcohol is treated with ninhydrin , a purple color is
produces after 15 min.
Uses :
 Anxiety state
 Depressive disorders
 Phobic state
 Obsessive disorder

16. Pharmaceutical formulations:
 Tranylcypromine and trifluoperazine tablets
 Tranylcypromine tablets
Brand name: Parnate , Parsetelline

17. 5. Imipramine

18. Chemical properties

19. Physical properties
 White or yellow crystalline powder.
 Odorless and bitter taste causes sensation of numbness.
 Soluble in water
Stability & storage
 It is affected by air ,hence it is stored in tight closed and light resistant container
Brand name: Impratab, Depsonil

20. Uses
 Anxiety disorders
 Depressive illness
 Phobic state
 Obsessive disorder
 Catalepsy
 Hyperactivity and attention deficit
 Allergic conjunctivitis
Pharmaceutical formulations: tablet, injection ,capsules, mixture