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The present study was undertaken to investigate the trends of antimicrobial resistance and identify antibiotics that are posing public health risk due to resistant microbes in Bangladesh. Antimicrobial resistance data of Bangladesh for last 10 years were searched out and compared with corresponding antibiotic consumption rates. In this study, a factor is introduced to identify the therapeutic sub-class of antibiotics that are mostly threatened by growing antimicrobial resistance. Highly resistance trend against several antibiotics such as cloxacillin, ampicillin, metronidazole, oxacillin, amoxicillin, tetracycline, cotrimoxazole, penicillin etc. were also indentified. Heat map analysis of this study revealed that nine antimicrobial agents: metronidazole, amoxicillin, tetracycline, cotrimoxazole, cephadine, penicillin, ciprofloxacin, doxycycline and nalidixic acid are associated with public health risk due to growing bacterial resistance. This study would significantly contribute in minimizing development and spread of antibiotic resistance by revealing the microbial resistance scenario and aid the effective antibiotic treatment options in Bangladesh.

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