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Antileprotic drugs
- 2. Content • Introduction • Classsification • Causes • Symptoms • Mode of action • Strucures • Dose • Brand names
- 3. Introduction Leprosy is a chronic disease caused by Mycobacterium leprae. it is directly effects nerves a nd mucous membrane. Leprosy, also known as Hansen's disease, is a chronic infectious disease caused by Mycobacterium leprae. The disease mainly affects the skin, the peripheral nerves, mucosal surfaces of the upper respiratory tract and the eyes. Leprosy is known to occur at all ages ranging from early infancy to very old age.
- 4. Causes Mycobacterium Leprae Close contact with people who's having leprosy Infected patient when sneezes
- 5. 5 Tuberculoid leprosy is a milder, less severe form of leprosy. People with this type have only one or a few patches of flat, pale-colored skin (called paucibacillaryleprosy). The affected are a of skin may feel numb because of nerve damage underneath. Tuberculoid leprosy is less contagious than other forms. Lepromatous leprosy is a more severe form of the disease. It has widespread skin bumps and rashes (called multibacillary leprosy), numbness, and muscle weakness.It is more contagious than tuberculoid leprosy. Types of leprosy
- 6. There is a two ways of leprosy presented Tuberculoid leprosy symptoms Lepromatous leprosy symptoms Sever pain Thickened skin on face Muscle weakness Nasal stiffness Skin stiffness and muscle dryness Bloody nose Loss of fingers and toes Laryngitis Eye problems Collapse of the nose blindness Swelling of the lymph nodes Enlarged nerves Enlargement of the male breast Symptoms
- 7. 7 Loss of fingers and toes Thickened skin on face Patches on the skin Skin lesions Nasal stiffness Red bumps Swelling of the lymph nodes
- 8. Mode of Action PABA Dihydrofolic acid Tetrahydrofolic acid Purin Synthesis DNA Synthesis DHF Synthtase DHF Reductase Dapsone
- 9. 9 Difference between G+ve and G-ve bacteria
- 10. 10
- 11. Classification Class Example of drugs Sulfone Dapsone, Solapsone Phenazine derivatives Clofazimine Antitubercular drugs Rifampicin, Ethionamide Thiourea derivative Thiambutosine
- 12. Dapsone Dapsone, also known as diaminodiphenyl sulfone (DDS) 4,4’- diamino diphenyl sulphone / Bis ( 4-amino phenyl) Sulphone
- 13. Properties White Crystalline powder Slightly Soluble in water It is declourises on exposure to light
- 14. It is used in the treatment of leprosy and in the combination of Rifampicin It has suppressive action on parasites In the treatment of dermatitis herpetiformis. ((DH) is a chronic, intensely itchy, blistering skin In combination with trimethoprim in the treatment of pneumonia Uses
- 15. Dose -25 -100 mg Official preparations- Dapsone .I.P,Dapsone tablets I.P Brand names-Dubronax
- 17. 17 Solapsone is an almost white powder, becomes anhydrous at in vacuo; exceedingly soluble in cold water, giving a neutral solution; practically insoluble in cold alcohol. Uses. Used to treat leprosy Dose.500mg Brand name -Solapsone Properties
- 19. Clofazimine exerts a slow bactericidal effect on Mycobacterium leprae (Hansen's bacillus). Clofazimine inhibits mycobacterial growth and binds preferentially to mycobacterial DNA. Clofazimine also exerts anti-inflammatory properties in controlling erythema nodosum leprosum reactions.
- 20. 20 Properties It forms dark crystals or reddish brown fine powder. Insoluble in water but soluble in chloroform. Uses. Used to treat leprosy. Dose. It is given in capsule form in 100 mg. Brand name. lamprene,Hansepran
- 22. 22 Properties White powder Insoluble in water Soluble in chlorofrom and ether Odourless and bitter taste Uses. used in the treatment of leprosy Dose.500 mg daily Official preparation. Thiambutosin I.P, Thiambutosin tablets I.P,
- 23. 59 Rifampicin
- 24. 86