Scripps 35th Annual Conference: Clinical Hematology & Oncology 2015 February 14-17, 2015 Hyatt Regency La Jolla, San Diego, California

1. 2015
scr i p p s ’ 3 5 th
Clinical
Annual conference :
Hematology
& Oncology
Saturday, February 14 – Tuesday, February 17, 2015
Hyatt Regency La Jolla at Aventine, San Diego, California

2. Course Introduction
Course Overview
Scripps’ 35th Annual Conference: Clinical Hematology and Oncology
2015, is designed for hematologists, oncologists, surgeons, radiation
oncologists, internists, and others desiring an update in these specialty
areas. The primary objective of this course is to bring together clini-cians
and leading experts in diverse areas of hematology and oncolo-gy,
affording them an intimate environment in which to discuss new
clinical developments and significant advances.
The first day of the program will focus on nonmalignant hematology
which will be followed by an update on hematologic malignancies
on the second day. New developments in oncology with a focus on
issues of current interest will be discussed on the third day, while the
final day will review breast cancer. All presenters will discuss their ap-proaches
to challenging but common clinical situations and there will
be ample time for participant interaction.
2015 Course Highlights
• Conference presentations will be available via mobile app and
conference website.
• Comprehensive presentations of the latest advances in cancer
diagnosis and treatment with a strong patient care focus
• One of the few educational conferences addressing nonmalignant
hematology
• Renowned faculty representing the country’s leading institutions
chosen for their expertise as well as teaching skills
• Meet the professor breakout sessions examining practical
approaches to various controversies in therapies discussed in a
highly dynamic, small-group setting
• Audience Response System used for instant feedback and inter-active
learning
• Multiple networking and one-on-one discussion opportunities
Educational Objectives
After attending this course, the attendee should be able to:
• Describe the clinical and molecular facets of pathogenesis,
diagnostic approaches and therapeutic modalities available for
various hematologic disorders.
• Select and apply the changing approaches to hematologic malig-nancies,
particularly as they relate to evidence-based standards of
care, including innovations in diagnosis and treatment.
• Choose new therapeutic options for the treatment of a number
of common malignancies; understanding appropriate indications
and contraindications to these therapeutic approaches.
• Integrate the evolving approaches to breast cancer from both a
diagnostic, prognostic and therapeutic perspective.
• Apply practical expertise gained from the clinical situations
discussed in the workshop sessions with an emphasis on data-based
approaches to patients with common but serious hematologic
conditions.
Accreditation
Physicians (MD, DO)
Scripps Health is accredited by the Accreditation Council for
Continuing Medical Education (ACCME) to provide continu-ing
medical education for physicians.
Scripps Health designates this educational activity for a max-imum
of 25.25 AMA PRA Category 1 Credit(s)™. Physicians
should only claim credit commensurate with the extent of
their participation in the activity.
Credit Breakdown:
Main Conference – 25.25
Saturday – 7 Monday – 7.5
Sunday –7 Tuesday – 3.75
Board of Registered Nurses (BRN)
For the purpose of recertification, the American Nurses
Credentialing Center accepts AMA PRA Category 1 Credits™
issued by organizations accredited by the ACCME. For the
purpose of re-licensure, the California Board of Registered
Nursing accepts AMA PRA Category 1 Credits™. Most
states’ Board of Registered Nursing accept AMA PRA Cate-gory
1 Credit(s)™ as meeting continuing education require-ments
for license renewal. Nurses should check with their
state board regarding use of CME credit
Physician Assistants (AAPA)
AAPA accepts Category I credit from AMA Category I CME
organizations accredited by ACCME.
Disclosure
Commercial Support
This course is supported, in part, by educational grants
from industry, in accordance with ACCME accreditation
Standards for Commercial Support. At the time of print-ing,
a complete listing of commercial supporters was not
available. Appropriate acknowledgement will be given to
all supporters at the time of the educational activity.
About Scripps
Scripps Proton Therapy Center in San Diego
offers advanced radiation therapy for the treatment of
cancerous tumors and certain non-cancerous conditions.
One of only 15 operating proton treatment centers in the
nation and the only proton therapy center in San Diego, the
facility features cancer-fighting technology that draws on
decades of research and development in radiation therapy
For more information about proton therapy at Scripps visit:
www.scripps.org/services/cancer-care__proton-therapy.
Scripps Cancer Care is committed to combating
cancer. As one of only two Integrated Network Cancer
Programs in California (as designated by the American
College of Surgeons), we mobilize all the oncology
resources of five hospital campuses, a broad network of
cancer care specialists, affiliated physicians and renowned
Scripps research professionals to help diagnose, treat and
support patients facing cancer—in San Diego and be-yond.
Working collaboratively toward cancer prevention,
early detection and coordinated cancer treatment, our
cancer care services are here for you when you need
them. Our multidisciplinary approach ensures a compre-hensive
treatment plan that pairs leading-edge technol-ogy
with an experienced, respectful care staff who are
sensitive to the whole person and a range of healing
approaches. Patients benefit from a collective array of
cancer-specific personnel and services, as well as vigorous
dialog between researchers and clinicians that brings the
latest medical knowledge bedside.
For more information about cancer care at Scripps visit:
www.scripps.org/services/cancer-care.

3. Jeffrey Andrey, MD
Division of Hematology & Oncology
Blood and Marrow Transplantation
Scripps Clinic
La Jolla, California
Carrie Costantini, MD
Hematology and Medical Oncology
Associate Director
Internal Medicine Residency Program
Scripps Mercy Hospital
San Diego, California
Cynthia Crist, DNP,
FNP-BC, AOCNP®
Supervisor
Woltman Family Infusion Center
Scripps Cancer Center
Scripps Mercy Hospital, San Diego
San Diego, California
Joan Kroener, MD
Director, Breast Program
Scripps Clinic
La Jolla, California
Course Director
Michael Kosty, MD, FACP,
FASCO
Medical Director
Scripps Green Cancer Center
Director
Graduate Medical Education
Scripps Clinic/Scripps Green Hospital
La Jolla, California
James Mason, MD
Director, Scripps Clinical Research
and Continuing Medical Education
Director, Scripps Blood and
Marrow Transplant Program
Scripps Clinic
La Jolla, California
Marie Shieh, MD
Division of Hematology & Oncology
Scripps Memorial Hospital, La Jolla
La Jolla, California
Darren Sigal, MD
Division of Hematology & Oncology
Scripps Clinic
La Jolla, California
James Sinclair, MD
Medical Director, Stevens Division
Scripps Cancer Center
La Jolla, California
William Stanton, MD
Medical Director
Scripps Cancer Center Mercy Hospital
San Diego, California
Melissa Torrey, MD
Division of Hematology & Oncology
Scripps Clinic
La Jolla, California
Sabina R. Wallach, MD,
FRACP, FACP
Hematology and Medical Oncology
Chief of Staff Emeritus
Scripps Memorial Hospital, La Jolla
La Jolla, California
Marin Xavier, MD
Hematology and Medical Oncology
Medical Director, Cancer Research
Associate Director
Internal Medicine Residency Program
Scripps Mercy Hospital
San Diego, California
Guest Faculty
Donald Abrams, MD
Professor of Clinical Medicine,
University of California, San Francisco
Integrative Oncology
UCSF Osher Center for
Integrative Medicine
Chief of Hematology/Oncology,
San Francisco General Hospital
San Francisco, California
James Armitage, MD,
FASCO
Professor, Internal Medicine
Division of Hematology & Oncology
University of Nebraska Medical Center
Omaha, Nebraska
Priscilla Kaliopi Brastianos,
MD
Director
Central Nervous System
Metastasis Program
Assistant Physician in Medicine
Massachusetts General Hospital
Cancer Center
Harvard Medical School
Boston, Massachusetts
John Vernon Cox, DO,
MBA, FACP, FASCO
Texas Oncology Methodist
Cancer Center
Education Chair
ASCO Cancer Education Committee
Editor-in-Chief
Journal of Oncology Practice
Dallas, Texas
George D. Demetri, MD,
FASCO
Director, Center for Sarcoma
and Bone Oncology
Senior Vice President for
Experimental Therapeutics
Professor of Medicine
Harvard Medical School
Dana-Farber Cancer Institute
Boston, Massachusetts
Terry Gernsheimer, MD
Professor of Medicine
Division of Hematology
University of Washington
School of Medicine
Medical Transfusion Services
University of Washington Medical
Center and Seattle Cancer Care Alliance
Seattle, Washington
Morie Gertz, MD, MACP
Chair, Department of Medicine
Mayo Clinic
Rochester, Minnesota
Stephen M. Hahn, MD
Henry K. Pancoast Professor and Chair
Department of Radiation Oncology
Perelman School of Medicine at the
University of Pennsylvania
Philadelphia, Pennsylvania
Arti Hurria, MD
Director
Cancer and Aging Research Program
Associate Professor, City of Hope
Durate, California
J. Randolph Hecht, MD
Professor of Clinical Medicine
David Geffen School of Medicine at
UCLA School of Medicine
Carol and Saul Rosenzweig Chair
Cancer Therapies Development
Director, UCLA Gastrointestinal
Oncology Program
Los Angeles, California
Maha Hussain, MD, FACP,
FASCO
Cis Maisel Professor of Oncology
Professor of Medicine and Urology
Associate Director for Clinical Research
Co-Leader, Prostate Cancer Program
University of Michigan
Comprehensive Cancer Center
Ann Arbor, Michigan
Maxine S. Jochelson, MD
Director of Radiology, Breast
and Imaging Center
Memorial Sloan Kettering
Cancer Center
New York, New York
Hagop Kantarjian, MD
Professor of Medicine
Chairman, Department of Leukemia
MD Anderson Cancer Center
University of Texas
Houston, Texas
Raj Kasthuri, MD
Director, UNC HHT Center
of Excellence
Associate Professor
Division of Hematology/Oncology
UNC Chapel Hill
Chapel Hill, North Carolina
John Kelton, MD, FRCPC
Professor
Pathology and Molecular Medicine
Dean & Vice- President
Faculty of Health Sciences
Professor of Medicine
McMaster University
Hamilton, Ontario
Stephanie Lee, MD, MPH
Director, Long-Term Follow-Up Program,
Seattle Cancer Care Alliance/Fred
Hutchinson Cancer
Research Center
Professor of Medical Oncology
University of Washington
School of Medicine
Seattle, Washington
Alice Ma, MD
Associate Professor of Medicine
Division of Hematology/Oncology
University of North Carolina
School of Medicine
Chapel Hill, North Carolina
Robert Stephen Makar,
MD, PhD
Assistant in Pathology
Associate Director
Blood Transfusion Service
Massachusetts General Hospital
Assistant Professor
Harvard Medical School
Boston, Massachusetts
Stephan Moll, MD
Professor of Medicine
Division of Hematology/Oncology
University of North Carolina
School of Medicine
Chapel Hill, North Carolina
Susan O’Brien, MD
Ashbel Smith Professor
Department of Leukemia
Division of Cancer Medicine
The University of Texas MD Anderson
Cancer Center
Houston, Texas
Thomas Ortel, MD, PhD
Professor of Medicine & Pathology
Chief, Division of Hematology
Director
Anticoagulation Management Service
Director
Duke Clinical Coagulation and
Platelet Immunology Laboratories
Duke University School of Medicine
Durham, North Carolina
Edith A. Perez, MD
Deputy Director at Large
Mayo Clinic Cancer Center
Group Vice Chair
Alliance for Clinical Trials in Oncology
Serene M. and Frances C. Durling
Professor of Medicine
Director, Breast Cancer
Translational Genomics Program
Hematology/Oncology and
Cancer Biology
Mayo Clinic
Jacksonville, Florida
David L. Porter, MD
Jodi Fisher Horowitz Professor in
Leukemia Care Excellence
Director
Blood and Marrow Transplantation
Hospital of the University
of Pennsylvania and
Abramson Cancer Center
Philadelphia, Pennsylvania
Christy Russell, MD
Associate Professor of Medicine
University of Southern California
Los Angeles, California
Joshua D. Schiffman, MD
Associate Professor, Pediatrics
Adjunct Associate Professor
Oncological Sciences
University of Utah
Salt Lake City, Utah
H. Irene Su, MD, MSCE
Assistant Professor
Division of Reproductive
Endocrinology and Infertility
University of California, San Diego
La Jolla, California
Theodore (Ted) E.
Warkentin, MD
Professor, Department of Pathology and
Molecular Medicine
and Department of Medicine
McMaster University
Hamilton, Ontario, Canada
Michael E. Williams, MD
Chief
Hematologic Malignancies Section
Byrd S. Leavell Professor of Medicine
Hematology and Oncology
University of Virginia School of Medicine
Charlottesville, Virginia
Anas Younes, MD
Chief, Lymphoma Service
Memorial Sloan-Kettering
Cancer Center
New York, New York
Faculty Disclosure: In accordance with the
ACCME Standards for Commercial Support, course
directors, planning committees, faculty and all oth-ers
in control of the educational content of the CME
activity must disclose all relevant financial relation-ships
with any commercial interest that they or their
spouse/partner may have had within the past 12
months. If an individual refuses to disclose relevant
financial relationships, they will be disqualified from
being a part of the planning and implementation of
this CME activity. Employees of a commercial inter-est
with business lines or products relating to the
content of the CME activity will not participate in
the planning or any accredited portion of the con-ference.
Disclosure will be made to all participants
at the conference location, prior to the educational
activity commencement.
Course Planning Committee
Faculty

4. Saturday, February 14, 2015
Nonmalignant Hematology
7 a.m. Registration, Breakfast & View Exhibits
7:50 a.m. Welcome and Introduction
Michael P. Kosty, MD
Morning Moderator: William Stanton, MD
8 a.m. Challenging Situations in Transfusion
Medicine: Indications for Red Cell,
Platelet and FFP Transfusion
Robert Makar, MD, PhD
8:45 a.m. Heparin Induced Thrombocytopenia - 2015
John Kelton, MD
9:30 a.m. Break & View Exhibits
10 a.m. Acquired von Willebrand Syndrome
and Cardiovascular Disease
Ted Warkentin, MD
10:45 a.m. Venous Thromboembolism: Special
Management Issues
Thomas Ortel, MD
11:30 a.m. The Patient Who Bleeds after Surgery -
What the Hematologist Needs to
Think About
Terry Gernsheimer, MD
12:15 p.m. Lunch
Afternoon Moderator: Marin Xavier, MD
1:15 p.m. Less Common Clots
Stephan Moll, MD
2 p.m. Iron Disorders - Iron Deficiency and
Hemochromatosis
Raj Kasthuri, MD
2:45 p.m. Mild Cytopenias: How much
Workup to do?
Alice Ma, MD
3:30 p.m. Break & View Exhibits
4 p.m. Meet the Professor
1. Patients with Thrombocytopenia
John Kelton, MD
2. Consumptive Coagulopathies
Ted Warkentin, MD
3. VTE Update
Stephan Moll, MD
4. Hemolytic Anemias
Alice Ma, MD
5. A Practical Approach to Anemia
Raj Kasthuri, MD
5 p.m. Adjourn
5 – Welcome & Networking Reception
6:30 p.m.
Sunday, February 15, 2015
malignant Hematology
7 a.m. Breakfast & View Exhibits
Morning Moderator: Alan Saven, MD
8 a.m. Molecular Monitoring and Mutations
in Chronic Myeloid Leukemia: How to
Get the Most out of Your Tyrosine
Kinase Inhibitor
Hagop Kantarjian, MD
8:45 a.m. Surveillance Imaging for Lymphoma:
Pros and Cons
James Armitage, MD
9:30 a.m. Break & View Exhibits
10 a.m. Incorporating New Agents into the
Treatment of CL
Susan O’Brien, MD
10:45 a.m. Mantle Cell Lymphoma: Biology,
Clinical Presentation, and Therapeutic
A pproaches
Michael Williams, MD
Schwartz Lecture
11:30 a.m. Genetically Engineered T-cells and
Beyond: Immune Modulation in CL
David Porter, MD
12:15 p.m. Lunch
Afternoon Moderator: Jeffrey Andrey, MD
1:15 p.m. Is There Still a Role for High-Dose
Melphalan in the Treatment of
Multiple Myeloma?
Morie Gertz , MD
2 p.m. Survivorship Issues Post Transplant
Stephanie Lee, MD
2:45 p.m. Advances in the Treatment of
Advanced Stage Hodgkin Disease
Anas Younes, MD
3:30 p.m. Break & View Exhibits
4 p.m. Meet the Professor (repeat from Saturday)
1. Patients with Thrombocytopenia
John Kelton, MD
2. Consumptive Coagulopathies
Ted Warkentin, MD
3. VTE Update
Stephan Moll, MD
4. Hemolytic Anemias
Alice Ma, MD
5. A Practical Approach to Anemia
Raj Kasthuri, MD
5 p.m. Adjourn
Program

5. Monday, February 16, 2015
Updates in Oncology
7 a.m. Breakfast & View Exhibits
Morning Moderator: Carrie Costantini, MD
8 a.m. Proton Therapy of Solid Tumors -
Point: Counterpoint
Stephen Hahn, MD
8:45 a.m. Optimal management of CNS
metastasis
Priscilla Brastianos, MD
9:30 a.m. Break & View Exhibits
Longmire Lecture
10 a.m. Perioperative Management of Locally
Advanced Esophagogastric Cancer
J. Randolph Hecht, MD
10:45 a.m. Sarcomas: From Chemotherapy to
Targeted Therapy
George Demetri, MD
11:30 a.m. Hereditary Cancer Syndromes
Joshua Schiffman, MD
12:15 p.m. Lunch
Afternoon Moderator: Sabina R. Wallach, MD , FRACP, FACP
1:15 p.m. Genomic Profiling of Tumors -
What is the standard of care?
TBD
2 p.m. Is There Currently an Established
Role for the Use of Predictive or
Prognostic Molecular Markers in the
Management of Colorectal Cancer
Darren Sigal, MD
2:45 p.m. Management of Early Recurrent or
Advanced Prostate Cancer
Maha Hussain, MD
3:30 p.m. Break & View Exhibits
4 p.m. The Rational Use of Supplements in
Cancer Care
Donald Abrams, MD
4:45 p.m. Community Oncology in an Era of
Payment Reform
John Cox, DO
5:30 p.m. Adjourn
Tuesday, February 17, 2015
Breast Cancer Update
7 a.m. Breakfast
Morning Moderator: Joan Kroener, MD
7:30 a.m. Fertility Preservation in Breast
Cancer Patients
Irene Su, MD
8:15 a.m. HER-2 directed therapy in Breast Cancer
Edith Perez, MD
9 a.m. Break
9:15 a.m. Imaging in Breast Cancer Patients -
What’s Appropriate?
Maxine Jochelson, MD
10 a.m. Adjuvant Therapy for Older Women with
Early-Stage Breast Cancer
Arti Hurria, MD
10:45 a.m. Optimal Management of the Pre-menopausal
Patient with Estrogen
Receptor–Positive Breast Cancer
Christy Russell, MD
11:30 a.m. Final Adjournment

6. Conference Location & Hotel Information
Hyatt Regency La Jolla at Aventine
3777 La Jolla Village Drive
San Diego, CA 92122
Reservations: 888-421-1442
Hotel Direct: 858-552-1234
Web: hyattregencylajolla.com
Rates & Reservations
We have obtained a special rate starting at $239 per
night (plus tax). This rate includes:
• Discounted day and overnight self-parking for $15
• Complimentary high speed wired internet in guestroom
Make your reservations early! A block of rooms is be-ing
held for Scripps until Monday, January 12, 2015. After
January 12, 2015 reservations will be accepted on a space
and rate availability basis only. Please make your own res-ervations
and be sure to mention the Scripps conference to
receive the reduced rate and conference amenities.
Please note: Attendees who book their room through
an online, third-party service (Hotels.com©, Expedia.
com©, Priceline.com©, etc.) are not eligible to receive
the ameni­ties
listed under the rate information.
Download the Scripps CME App
All conference information including a detailed agenda, faculty listing, faculty disclosures, industry support, at-tendee
list, and course materials can be found on the free Scripps CME conference app for iPhone, iPad, Android,
and BlackBerry. To download the app on your smart phone or other device visit the appropriate app store and
search ScrippsCME (must be one word). The app is free of charge and will be continuously updated during and
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To access the site using your cell phone or computer’s web browser: http://www.grupio.com/ScrippsCME

7. Fees & Registration – February 14 - February 17, 2015
Clinical Hematology & Oncology
conference fees
Included with full conference registration: Course tuition, access to conference
materials (via mobile app and conference website), internet in meeting space,
breakfasts, breaks, lunches and the Welcome Reception
Not Included: Printed course syllabus (presentations available via mobile app and
conference website), travel costs, parking, lodging and dinners
Full Conference Thru Jan 2 Jan 3 - Feb 6
F i r s t n a m e , m i , L a s t Na m e D e g r e e (MD , D O , P h D , RN, e t c )
Ways to Register
Online scripps.org/hemonccme
Fax 858-652-5565
Mail Scripps Conference Services & CME
Clinical HemOnc
11025 North Torrey Pines Rd.
Suite 200, Maildrop: SCRC 200
La Jolla, California 92037
Attendance Policies
registration confirmation
A confirmation letter will be e-mailed or
mailed to you upon receipt of the con-ference
registration form and payment. If
you have not received it within two weeks,
please contact the Scripps Conference Ser-vices
& CME office.
attendee cancellation,
substitution, refund
The course tuition is refundable, minus a
$100 processing fee ($25 for Fellows and
Residents), if your cancellation is received
in writing no later than Friday, February 6,
2015. Attendee substitutions are allowed,
but notification must be made in writing by
February 6, 2015. After this date, under no
circumstances will refunds, credits, or sub-stitutions
be granted. No refunds or credits
will be given to “no shows.”
scripps conference
modification or cancellation
Scripps reserves the right to modify the
course’s schedule or program as necessary.
Scripps also reserves the right to cancel this
conference, in which case a full refund of
the registration fee will be provided. We
are unable to refund any travel costs (flight,
hotel, etc.) in the case of Scripps cancellation.
B a d g e Na m e ( i f d i ffe r e n t f rom a bov e ) Aff i l i at ion /Hos p i ta l / Compa n y s p e c i a l t y
d i r e c t Ma i l i n g Addr e s s
C i t y / S tat e / z i p c ode
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e m a il Assistant E-Mai l
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B i lli n g Addr e s s i f D i ffe r e n t f rom Abov e
On-site
after Feb 6
Physicians $600 $650 $675
Nurses/Nurse Practitioners/Physician Assistants/ $425 $475 $500
Pharmacists/Allied Health Professionals
Fellows and Residents $150 $200 $225
Day Rate: (circle days)
Saturday Sunday Monday Tuesday
Thru Jan 2 Jan 3 - Feb 6 On-site
after Feb 6
Day Rate $250 $300 $325
saturday welcome reception
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I would like to purchase additional Welcome Reception tickets at $15/each # tickets
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(this is included with the cost of main and day conference registration rates) $199
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9

8. f o l l o w u s !
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2015
scr i p p s ’ 3 5 th
Clinical
Annual conference :
Scripps Conference Services & CME
11025 N. Torrey Pines Rd., Suite 200
La Jolla, California 92037
www.scripps.org/conferenceservices
Hematology
& Oncology
Saturday, February 14 – Tuesday, February 17, 2015
Hyatt Regency La Jolla at Aventine, San Diego, California
2015
scr i p p s ’ 3 5 th
Clinical
Annual conference :
Hematology
& Oncology
Saturday, February 14 – Tuesday, February 17, 2015
Hyatt Regency La Jolla at Aventine, San Diego, California
Target Audience
• Hematologists/
Oncologists
• Medical Oncologists
• Surgeons
• Radiation Oncologists
• Internists
• Nurse Practitioners
• Physician Assistants
• Nurses and others
desiring an update in
these specialty areas
Scripps Conference Services & CME
Phone: 858-652-5400
Online: www.scripps.org/conferenceservices
mailto: med.edu@scrippshealth.org