2. LightLab OCT
Optical Coherence
Tomography (OCT) is a new
class of ultra high-resolution
imaging technology using
near infrared light.
In addition to morphological imaging,
LightLab OCT is capable of:
Spectroscopic Imaging
Polarization Imaging
Doppler
Elastography
3. Real time Imaging (to 30fps)
Portable & Modular Design
Digital System Architecture
LightLab Imaging PlatformLightLab Imaging Platform
(Pending 510(k) Clearance)
LightLab OCT
.006” micro-optic core
Microscopic resolution (12 µm)
.014” ImageWire & Balloon
Imaging System
Catheters
8. Precision Imaging
OCT Cine Pullback
Human Cadaver Circumflex Artery
Thin Capped LesionsThin Capped Lesions
9. Precision Imaging
Pull-back in stentPull-back in stent (note early side branch)(note early side branch)
In-vivo HumanIn-vivo Human
.014” ImageWire
Prof. Eberhard Grube, Siegburg Heart Center
10. Precision Imaging
In-vivo Human Lesion 400 micrometer capIn-vivo Human Lesion 400 micrometer cap
.014” ImageWire
Prof. Eberhard Grube, Siegburg Heart Center
11. Bringing a microscope into theBringing a microscope into the
coronaries improves the clinicians abilitycoronaries improves the clinicians ability
to:to:
Select the appropriate therapy
Titrate the delivery of specific therapies
Direct the delivery to targeted lesions
Develop entire new therapeutic approaches
Precision Therapy
16. Polarization
Information for a better understanding ofInformation for a better understanding of
microanatomic plaque characteristicsmicroanatomic plaque characteristics
Evaluate plaque
structure and
orderliness
Grey Scale
Detailed
Morphological
understanding
Cap thickness, identify
fissures, calcium, lipid
Cap/plaque Fiber
Spectroscopy
Determine
chemical content
of visualized
lesions
Lipid concentration
Polarization
LightLab OCT Technology
17. Different tissues exhibit differentDifferent tissues exhibit different
polarization effectspolarization effects
OCT
is inherently sensitive to
changes in the polarization
of the probe beam.
Birefringence
is the major source
of contrast in polarization-
sensitive OCT imaging.
Very High
Very low
Media (healthy)
Cholesterol crystals
Soft (lipid) plaque
Fibrotic plaque
Intima (healthy)
Calcified plaque
Structure
Birefringence
LightLab OCT Technology
19. Magnitude
Polarization
Combined
Grey scale and polarization information may beGrey scale and polarization information may be
combined to localize and identify tissuecombined to localize and identify tissue
characteristicscharacteristics
Platform FuturesPlatform Futures
20. Polarization
Evaluate plaque
structure and
orderliness
Grey Scale
Detailed
Morphological
understanding
Cap thickness, identify
fissures, calcium, lipid
Cap/plaque Fiber
Spectroscopy
Determine
chemical content
of visualized
lesions
Lipid concentration
Polarization
LightLab OCT Technology
Information for a better understanding ofInformation for a better understanding of
microanatomic plaque characteristicsmicroanatomic plaque characteristics
21. Lipid imaging in phantom
Spectroscopic image
Lipid+calcium Protein+calcium
Gray-scale image
Lipid+calcium Protein+calcium
OCT Spectroscopy identifies differences in
composition
LightLab OCT Technology