This document summarizes several studies that used microarray technology to analyze gene expression in cardiovascular tissues and cells: 1) Studies analyzed atherosclerotic lesions and correlated gene expression with the vulnerability and pathogenesis of lesions. 2) Other studies analyzed gene expression changes in cardiac growth, development, and response to injury as well as during viral infection. 3) Gene expression in vascular cells and tissues was also analyzed in response to mechanical stress, inflammation, and other cardiovascular conditions like atherosclerosis and hypertension.

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Studies done on
atherosclerotic lesions,
correlating their
vulnerability and their
pathogenesis with
molecular genetics and
assessing their results by
micro arrays

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 Patricia D. Sehl, Julie T. N. Tai, Kenneth J. Hillan, Lesley A. Brown, Audrey
Goddard, Renhui Yang, Hongkui Jin, and David G. Lowe
 Application of cDNA Microarrays in Determining Molecular Phenotype in
Cardiac Growth, Development, and Response to Injury
Circulation 2000 101: 1990-1999. [A] [Full Text]

:
 Lydia A. Taylor, Christopher M. Carthy, Decheng Yang, Kareem Saad, Donald
Wong, George Schreiner, Lawrence W. Stanton, and Bruce M. McManus
 Host Gene Regulation During Coxsackievirus B3 Infection in Mice :
Assessment by Microarrays
Circ. Res. 2000 87: 328-334. [A
 bstract] [Full Text] [Data Supplement]
 Lawrence W. Stanton, Lisa J. Garrard, Deborah Damm, Brett L. Garrick,
Andrew Lam, Ann M. Kapoun, Qiang Zheng, Andrew A. Protter, George F.
Schreiner, and R. Tyler White
 Altered Patterns of Gene Expression in Response to Myocardial Infarction
Circ. Res. 2000 86: 939-945. [Abstract] [Full Text] [Methods][Data Set]

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. [Abstract] [Full Text]
Yajun Feng, Jeong-Hee Yang, Hayden Huang, Scott P. Kennedy, Thomas G. Turi, John F.
Thompson, Peter Libby, and Richard T. Lee
Transcriptional Profile of Mechanically Induced Genes in Human Vascular Smooth
Muscle Cells
Circ. Res. 1999 85: 1118-1123
 Kathleen J. Haley, Craig M. Lilly, Jeong-Hee Yang, Yajun Feng, Scott P. Kennedy,
Thomas G. Turi, John F. Thompson, Galina H. Sukhova, Peter Libby, and Richard T. Lee
Overexpression of Eotaxin and the CCR3 Receptor in Human Atherosclerosis : Using
Genomic Technology to Identify a Potential Novel Pathway of Vascular Inflammation
Circulation 2000 102: 2185-2189. [Abstract] [Full Text]
Maha Abdellatif
Leading the Way Using Microarray : A More Comprehensive Approach for Discovery
of Gene Expression Patterns
Circ. Res. 2000 86: 919-920. [Full Text]
Anna F. Dominiczak, Domingo C. Negrin, James S. Clark, M. Julia Brosnan, Martin W.
McBride, and M. Yvonne Alexander
Genes and Hypertension : From Gene Mapping in Experimental Models to Vascular
Gene Transfer Strategies
Hypertension 2000 35: 164-172. [Abstract] [Full Text]


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• CDNA ARRAY ANALYSIS OF GENE EXPRESSION IN THE AORTAS OF APOLIPOPROTEIN-
E DEFICIENT MICE WITH ATHEROSCLEROSIS
Yong-Jian Geng, Ki-Soo Kil, S Ward Casscells, Univ of Texas Houston Medical Sch, Texas Heart Inst,
Houston, TX; James T Willerson, Texas Heart Inst, Houston, TX EXPR
ESSION OF THE UNCOUPLING PROTEIN UCP-2 IN
• MACROPHAGES OF UNSTABLE HUMAN ATHEROSCLEROTIC PLAQUES
Mark M Kockx, Az Middelheim, Antwerp Belgium; Michiel W M Knaapen, CV Translational Research Inst
Middelheim, Antwerp Belgium; Wim Martinet, Univ of Antwerp, Antwerp Belgium; Guido R Y De Meyer,
Univ of Antwerp - UIA, Antwerp Belgium; Stefan Verheye, CV Translational Research Inst Middelheim,
Antwerp Belgium; Arnold G Herman, Univ of Antwerp - UIA, Antwerp Belgium
•Identification of atherosclerosis-related genes; construction of a cardiovascular microarray
S. van Soest, R.D. Fontijn, H. Pannekoek and A.J.G. Horrevoets.
Department of Biochemistry, AMC, Amsterdam

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•Mark M Kockx :Expression of the Uncoupling Protein UCP-2 in Macrophages of Unstable Human
Atherosclerotic Plaques
•Manabu Minami : Expression of SR-PSOX, a Novel Macrophage Receptor for Oxidized LDL, in Human
Atherosclerotic Lesions
•Jaap Twisk : Gene Regulation in Atherosclerosis and Vascular Biology
•Inflammation in cardiovascular disease
Iqbal S Malik MA MB MRCP, Research Fellow, BHF Cardiovascular Medicine Unit, Hammersmith
Hospital, London
J R Coll Physicians Lond 2000;34:205-7
The use of microarray technology to describe patterns of gene expression in atherosclerosis will
allow a more detailed understanding of the mechanisms controlling the response to injury in the
arterial wall, and may in due course be helpful in establishing genetic risk profiles

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acrophage function inlipoprotein[sol ]cholesterol metabolism and atherosclerosisher Bunker; Jessie
hristopher Bunker, Jessie Gu; Zuwei Qian; Vincent Chan; Uli Thomann; Brad Guild;
ature Genetics Volume 23 Number 3 Page 35 (1999)
ll Text | PDF

7. 12/9/00 61
acrophage function inlipoprotein[sol ]cholesterol metabolism and atherosclerosisher Bunker; Jessie
hristopher Bunker, Jessie Gu; Zuwei Qian; Vincent Chan; Uli Thomann; Brad Guild;
ature Genetics Volume 23 Number 3 Page 35 (1999)
ll Text | PDF