The document discusses Advil (ibuprofen), including its classification as a nonsteroidal anti-inflammatory drug, indications for use in relieving pain, fever, and inflammation, recommended dosages, and potential side effects like gastrointestinal issues. It also lists other Advil products beyond the original tablets and warns that Advil can cause drowsiness, affect the heart, and should not be used in the third trimester of pregnancy due to risks for premature ductus arteriosus closure.

1. By: Jennifer Pereira and Sahar Osmany

2.  Ibuprofen without prescription 1984: Advil
 1974: Recommended dose 1200-3200 mg/day
 1984: Need for Mass Production
 1988: Huge Sales = Huge Production

3.  PHARMACOLOGICAL CLASSIFICATION:
 A.2.7 Antipyretic and anti-inflammatory analgesics.
 PHARMACOLOGICAL ACTION:
 ADVIL is a non-steroidal compound with analgesic, anti-inflammatory and antipyretic
activities.
 INDICATIONS:
 ADVIL is indicated for the relief of dental pain, menstrual pain, headache from musculo-
skeletal origin, feverishness, and muscular aches and pain.
 CONTRA-INDICATIONS:
 ADVIL is not recommended for use by pregnant women.
 WARNINGS:
 ADVIL should not be given to patients with bleeding disorders, cardiovascular disease, peptic
ulceration or a history of such ulceration. Caution is advised to those patients who are
receiving coumarin anticoagulants. If you are breast-feeding, seek the advice of a health
professional before using this product. Patients who are allergic or sensitive to aspirin should
not be given ADVIL.

4.  DOSAGE AND DIRECTIONS FOR USE:
 Adults and Children over 12 years.
 Initial dose:Two tablets taken with water. Then if necessary, 1 or 2 tablets every four hours. Do not exceed 6
tablets in any 24 hours. ADVIL must be taken with food or after meals.
 Not to be given to children under 12 years.
 Do not use continuously for more than 3 days for fever or more than 7 days for pain without consulting a
doctor.
 SIDE-EFFECTS AND SPECIAL PRECAUTIONS:
 Dyspepsia, gastro-intestinal intolerance and bleeding may occur. Other side-effects include nervousness, skin
rash, pruritus, tinnitus, oedema, depression, drowsiness, insomnia, blurred vision and other visual field
defects. Sensitivity reactions, abnormalities of liver function tests, impairment of renal function,
agranulocytosis and thrombocytopenia have been observed. Acute reversible renal failure has been reported.
ADVIL should be used with care in patients with impaired renal function.
 KNOWN SYMPTOMS OF OVERDOSAGE AND PARTICULARS OF ITS TREATMENT:
 The most likely symptoms of overdosage are epigastric pain and nausea. If recently taken, gastric lavage will
remove any unabsorbed ibuprofen. Electrolytes may be corrected by intravenous infusions, if necessary.
Dialysis may be done as Ibuprofen is not strongly protein bound. There is no specific antidote to ADVIL.
 IDENTIFICATION:
 Pink, biconvex, film-coated tablets with a diameter of about 10,5 mm.
 PRESENTATION:
 Blister packs of 10, 20 and 30 tablets.

5.  Advil PM
 Advil Liquid Gels
 Children’s Advil
 Advil Congestion Relief
 Advil Cold & Sinus
 Advil Allergy Sinus
 Advil Migraine

6.  Makes people drowsy
 Side effects on heart
 Third trimester of pregnancy :premature
closure of ductus arteriosus

7.  Legal
 Over the Counter

8. LONG TERM SHORT TERM
 Rapid Weight Gain
 Odd changes in
urination patterns
 Kidney problems
 Liver problems
 Yellowing of skin and
eyes
 Vision problems
 Coughing blood up
 Shortness of breath
 Promote Hypertension
 High Blood Pressure
 Acute Gastric Upset
 Stomach Ulcers

9.  Emergency Medical Help