In 2012, the U.S. market for orthopedic biomaterials was valued at almost $3.4 billion. This total comprises eight different market segments. The orthopedic biomaterials market has undergone a shift away from certain devices and towards new areas and medical devices. There is still tremendous potential for growth, especially in the younger market segments such as stem cells and concentration systems. https://www.reportscorner.com/reports/26973/U.S-Orthopedic-Biomaterials-Market/

1. RC
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U.S Orthopedic Biomaterials
Market

2. Description
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In 2012, the U.S. market for orthopedic biomaterials was valued at
almost $3.4 billion. This total comprises eight different market
segments.
The orthopedic biomaterials market has undergone a shift away
from certain devices and towards new areas and medical devices.
There is still tremendous potential for growth, especially in the
younger market segments such as stem cells and concentration
systems.

3. Brief Summary
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In 2012, the U.S. market for orthopedic biomaterials was valued at
almost $3.4 billion. This total comprises eight different market
segments.
The orthopedic biomaterials market has undergone a shift away from
certain devices and towards new areas and medical devices. There is
still tremendous potential for growth, especially in the younger market
segments such as stem cells and concentration systems. Conversely,
some products that previously experienced rapid market growth have
now entered maturity, but even these markets are sustained by
continued product evolution.
Scope: This report pertains to a forecast period of 10 years (2009 –
2019) for the U.S.
Report Contents:
Competitor Analysis
Identified Strategic Opportunities
Market Overview by Segment & Country

4. Brief Summary
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Trend Analysis by Segment & Country
Market Drivers & Limiters
Mergers & Acquisitions
Customer Feedback and Market Monitoring
Main Segments Included:
Orthopedic Bone Graft Substitute
Orthopedic Growth Factor
Orthopedic Stem Cell
Orthopedic Cell Therapy
Orthopedic Hyaluronic Acid Viscosupplementation
Orthopedic Tendon Graft
Orthopedic Cartilage Repair
Spinal Machined Bone Allograft
Sub-Segments Included:
Autograft
Standard Allograft

5. Brief Summary
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Demineralized Bone Matrix
Synthetic Bone Graft
Xenograft
BMP-2
BMP-7
Human Embryonic Stem Cells
Mesengchymal Stem Cells
Lumbar Spine Stem Cells
Cervical Spine Stem Cells
Platelet-Rich Plasma
Orthopedic Concentrated Bone Marrow Aspirate
Single-Injection
Three-Injection Cycle
Three/Five-Injection Cycle
BTB Graft

6. Brief Summary
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Soft Tissue Grafts
Ligament and Tendon Synthetic Graft
Osteochondral Allograft
Autologous Chondrocyte Implantation
Meniscal Allograft Tansplantation
ALIF Machined Bone Allograft
PLIF Machined Bone Allograft
TLIF Machined Bone Allograft
CIF Machined Bone Allograft
Companies Included:
Sanofi-Aventis/Genzyme
Bioventus
DePuy Synthes
Medtronic
Musculoskeletal Transplant Foundation

7. Brief Summary
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Stryker
RTI Biologics
NuVasive
Orthofix
LifeNet Health
AlloSource
Integra LifeSciences
Anika Therapeutics
Biomet
Ferring Pharmaceuticals
Exactech
Baxter
Harvest Technologies
Cytomedix
Wright Medical

8. Brief Summary
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Community Tissue Services
Olympus Biotech
Fidia
Arteriocyte
Alphatec Spine
Joint Restoration Foundation
University of Miami Tissue Bank
Celling Biosciences
Zimmer
Reasons To Buy:
This report analyzes and evaluates the current state of the market
including existing and potential markets, product average selling prices,
and unit volumes. The report also highlights the opportunities and
potential hazards involved, and presents strategies for successfully
navigating the market landscape.

9. Brief Summary
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Furthermore, it seeks to identify the trends and technologies that will
affect the future of each market segment and prepares an unbiased
critical assessment of such market drivers and limiters based on our
“ground up” approach, which includes primary and secondary research
methods.

10. Table of Contents
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TABLE OF CONTENTS ............................................................................................................................ I
LIST OF FIGURES ................................................................................................................................. IX
LIST OF CHARTS .................................................................................................................................. XV
EXECUTIVE SUMMARY ......................................................................................................................... 1
1.1 ORTHOPEDIC BIOMATERIALS MARKET OVERVIEW ................................................................................ 1
1.2 ORTHOPEDIC BONE GRAFT SUBSTITUTE MARKET .................................................................................. 2
1.3 ORTHOPEDIC GROWTH FACTOR MARKET ............................................................................................... 3
1.4 ORTHOPEDIC STEM CELL MARKET ......................................................................................................... 4
1.5 ORTHOPEDIC CELL THERAPY MARKET ................................................................................................... 5
1.6 ORTHOPEDIC HYALURONIC ACID VISCOSUPPLEMENTATION MARKET .................................................. 6
1.7 ORTHOPEDIC TENDON GRAFT MARKET .................................................................................................. 7
1.8 ORTHOPEDIC CARTILAGE REPAIR MARKET ............................................................................................ 8
1.9 COMPETITIVE ANALYSIS ......................................................................................................................... 9
RESEARCH METHODOLOGY ............................................................................................................. 11
2.1 RESEARCH SCOPE .................................................................................................................................. 11
2.2 IDATA’S 9-STEP METHODOLOGY .......................................................................................................... 11
Step 1: Project Initiation & Team Selection ................................................................................................ 12
Step 2: Prepare Data Systems and Perform Secondary Research .............................................................. 13
Step 3: Preparation for Interviews & Questionnaire Design ...................................................................... 14
Step 4: Performing Primary Research ........................................................................................................ 14
Step 5: Research Analysis: Establishing Baseline Estimates ...................................................................... 16
Step 6: Market Forecast and Analysis......................................................................................................... 17
Step 7: Identify Strategic Opportunities ...................................................................................................... 19
Step 8: Final Review and Market Release ................................................................................................... 20
Step 9: Customer Feedback and Market Monitoring .................................................................................. 20

11. Table of Contents
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ORTHOPEDIC BIOMATERIALS MARKET OVERVIEW ............................................................... 21
3.1 INTRODUCTION ...................................................................................................................................... 21
3.1.1 Bone Graft Substitutes ........................................................................................................................ 22
3.1.2 Growth Factors .................................................................................................................................. 22
3.1.3 Orthopedic Stem Cell Therapy ........................................................................................................... 23
3.1.4 Cell Therapies .................................................................................................................................... 23
3.1.5 Hyaluronic Acid Viscosupplementation ............................................................................................. 24
3.1.6 Tendon Grafts ..................................................................................................................................... 24
3.1.7 Cartilage Repair ................................................................................................................................. 24
3.2 MARKET OVERVIEW .............................................................................................................................. 25
3.3 TREND ANALYSIS .................................................................................................................................. 30
3.4 MARKET DRIVERS AND LIMITERS ......................................................................................................... 33
3.4.1 Market Drivers ................................................................................................................................... 33
3.4.2 Market Limiters .................................................................................................................................. 33
3.5 COMPETITIVE ANALYSIS ....................................................................................................................... 36
3.5.1 Leading Competitors .......................................................................................................................... 36
3.6 MARKET CONCENTRATION .................................................................................................................... 42
3.7 MERGERS AND ACQUISITIONS ............................................................................................................... 44
ORTHOPEDIC BONE GRAFT SUBSTITUTE MARKET ................................................................. 49
4.1 INTRODUCTION ...................................................................................................................................... 49
4.2 MARKET SEGMENTATION ...................................................................................................................... 50
4.2.1 By Indication ...................................................................................................................................... 50
4.2.1.1 Spine ................................................................................................................................................ 50
4.2.1.2 Thoracolumbar Spine ...................................................................................................................... 50
4.2.1.3 Cervical Spine ................................................................................................................................. 50
4.2.1.4 Trauma ............................................................................................................................................ 51
4.2.1.5 Extremities ....................................................................................................................................... 51

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4.2.2 By Material ......................................................................................................................................... 51
4.2.2.1 Autograft .......................................................................................................................................... 51
4.2.2.2 Standard Allograft ........................................................................................................................... 51
4.2.2.3 Demineralized Bone Matrix ............................................................................................................ 51
4.2.2.4 Synthetic .......................................................................................................................................... 52
4.2.2.5 Xenograft ......................................................................................................................................... 52
4.3 PROCEDURES ......................................................................................................................................... 53
4.3.1 Bone Graft Substitute Procedures ...................................................................................................... 53
4.4 UNITS PER PROCEDURE ......................................................................................................................... 54
4.5 MARKET OVERVIEW .............................................................................................................................. 56
4.5.1 Bone Graft Substitute Market by Material ......................................................................................... 58
4.5.2 Bone Graft Substitute Market by Indication ....................................................................................... 61
4.6 MARKET ANALYSIS & FORECAST ......................................................................................................... 64
4.6.1 Bone Graft Substitute Market by Material ......................................................................................... 64
4.6.1.1 Total Allograft Bone Graft Substitute Market ................................................................................. 64
4.6.1.2 Total Demineralized Bone Matrix (DBM) Bone Graft Substitute Market ....................................... 79
4.6.1.3 Total Synthetic Bone Graft Substitute Market ................................................................................. 96
4.6.2 Bone Graft Substitute Market by Indication ..................................................................................... 111
4.6.2.1 Spine Bone Graft Substitute Market .............................................................................................. 111
4.6.2.2 Cervical Spine Bone Graft Substitute Market ............................................................................... 113
4.6.2.3 Thoracolumbar Spine Bone Graft Substitute Market .................................................................... 115
4.6.2.4 Trauma Bone Graft Substitute Market .......................................................................................... 117
4.6.2.5 Non-union Trauma Fracture Bone Graft Substitute Market ......................................................... 119
4.6.2.6 Fresh Fracture Trauma Bone Graft Substitute Market ................................................................. 120
4.6.2.7 Large Joint Reconstruction Bone Graft Substitute Market ........................................................... 121
4.6.2.8 Hip Large Joint Reconstruction Bone Graft Substitute Market .................................................... 123
4.6.2.9 Knee Large Joint Reconstruction Bone Graft Substitute Market .................................................. 124

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4.6.2.10 Foot Reconstruction Bone Graft Substitute Market .................................................................... 125
4.6.2.11 Craniomaxillofacial Bone Graft Substitute Market..................................................................... 127
4.6.2.12 Oncology Bone Graft Substitute Market ..................................................................................... 129
4.7 MARKET DRIVERS AND LIMITERS ....................................................................................................... 131
4.7.1 Market Drivers ................................................................................................................................. 131
4.7.1.1 Allograft Bone Graft Substitute Market ........................................................................................ 131
4.7.1.2 Demineralized Bone Matrix (DBM) Bone Graft Substitute Market .............................................. 131
4.7.1.3 Synthetic Bone Graft Substitute Market ........................................................................................ 132
4.7.2 Market Limiters ................................................................................................................................ 134
4.7.2.1 Allograft Bone Graft Substitute Market ........................................................................................ 134
4.7.2.2 Demineralized Bone Matrix (DBM) Bone Graft Substitute Market .............................................. 134
4.7.2.3 Synthetic Bone Graft Substitute Market ........................................................................................ 135
4.8 COMPETITIVE ANALYSIS ..................................................................................................................... 136
4.8.1 Allograft Bone Graft Substitute Market ........................................................................................... 136
4.8.2 Demineralized Bone Matrix (DBM) Bone Graft Substitute Market ................................................. 140
4.8.3 Synthetic Bone Graft Substitute Market ........................................................................................... 143
4.8.4 Total Bone Graft Substitute Market ................................................................................................. 147
ORTHOPEDIC GROWTH FACTOR MARKET ............................................................................... 149
5.1 INTRODUCTION .................................................................................................................................... 149
5.2 MARKET OVERVIEW ............................................................................................................................ 149
5.2.1 BMP-2 (Medtronic) .......................................................................................................................... 150
5.2.2 BMP-7 (Olympus Biomaterials) ....................................................................................................... 150
5.2.3 Reimbursement ................................................................................................................................. 151
5.2.4 Future Indications ............................................................................................................................ 151
5.3 MARKET ANALYSIS & FORECAST ....................................................................................................... 152
5.4 MARKET DRIVERS AND LIMITERS ....................................................................................................... 154
5.4.1 Market Drivers ................................................................................................................................. 154

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5.4.2 Market Limiters ................................................................................................................................ 154
5.5 COMPETITIVE ANALYSIS ..................................................................................................................... 157
ORTHOPEDIC STEM CELL MARKET............................................................................................. 159
6.1 INTRODUCTION .................................................................................................................................... 159
6.2 MARKET OVERVIEW ............................................................................................................................ 159
6.2.1 Lineage ............................................................................................................................................. 159
6.2.1.1 Human Embryonic Stem Cells (hESC) .......................................................................................... 159
6.2.1.2 Mesenchymal Stem Cells (MSC) ................................................................................................... 160
6.2.2 Legislation ........................................................................................................................................ 160
6.2.3 Other Therapeutic Applications ....................................................................................................... 160
6.3 MARKET ANALYSIS & FORECAST ....................................................................................................... 161
6.3.1.1 Lumbar Spine Stem Cell Market ................................................................................................... 165
6.3.1.2 Cervical Spine Stem Cell Market .................................................................................................. 167
6.4 DRIVERS AND LIMITERS ...................................................................................................................... 169
6.4.1 Market Drivers ................................................................................................................................. 169
6.4.2 Market Limiters ................................................................................................................................ 169
6.5 COMPETITIVE ANALYSIS ..................................................................................................................... 171
ORTHOPEDIC CELL THERAPY MARKET .................................................................................... 175
7.1 INTRODUCTION .................................................................................................................................... 175
7.1.1 Platelet-Rich Plasma ........................................................................................................................ 176
7.1.2 Concentrated Bone Marrow Aspirate .............................................................................................. 177
7.2 MARKET OVERVIEW ............................................................................................................................ 178
7.3 MARKET ANALYSIS & FORECAST ....................................................................................................... 182
7.3.1 Platelet-Rich Plasma Market ........................................................................................................... 182
7.3.1.1 Spinal Platelet-Rich Plasma Market ............................................................................................. 187
7.3.1.2 Soft Tissue Reconstruction Platelet-Rich Plasma Market ............................................................. 188

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7.3.1.3 Joint Reconstruction Platelet-Rich Plasma Market ...................................................................... 189
7.3.1.4 Cardiac Surgery Platelet-Rich Plasma Market ............................................................................. 190
7.3.1.5 Other Platelet-Rich Plasma Markets ............................................................................................. 191
7.3.2 Orthopedic Concentrated Bone Marrow Aspirate Market ............................................................... 192
7.3.2.1 Spine Concentrated Bone Marrow Aspirate Market ..................................................................... 197
7.3.2.2 Trauma Concentrated Bone Marrow Aspirate Market ................................................................. 198
7.3.2.3 Joint Reconstruction Concentrated Bone Marrow Aspirate Market ............................................. 199
7.3.2.4 Other Concentrated Bone Marrow Aspirate Market ..................................................................... 200
7.4 MARKET DRIVERS AND LIMITERS ....................................................................................................... 201
7.4.1 Market Drivers ................................................................................................................................. 201
7.4.2 Market Limiters ................................................................................................................................ 202
7.5 COMPETITIVE ANALYSIS ..................................................................................................................... 204
ORTHOPEDIC HYALURONIC ACID VISCOSUPPLEMENTATION MARKET ....................... 207
8.1 INTRODUCTION .................................................................................................................................... 207
8.1.1 Benefits of Viscosupplementation ..................................................................................................... 208
8.1.2 Synovial Fluid .................................................................................................................................. 208
8.1.3 Product Types ................................................................................................................................... 209
8.1.3.1 Single-Injection Products .............................................................................................................. 209
8.1.3.2 Three-Injection Cycle Products ..................................................................................................... 209
8.1.3.3 Three/Five-Injection Cycle Products ............................................................................................ 209
8.1.4 Reimbursement ................................................................................................................................. 209
8.2 MARKET OVERVIEW ............................................................................................................................ 210
8.3 MARKET ANALYSIS & FORECAST ....................................................................................................... 214
8.3.1 Single-Injection Hyaluronic Acid Viscosupplementation Market .................................................... 214
8.3.2 Three-Injection Hyaluronic Acid Viscosupplementation Market ..................................................... 216
8.3.3 Five-Injection Hyaluronic Acid Viscosupplementation Market ....................................................... 218
8.4 MARKET DRIVERS AND LIMITERS ....................................................................................................... 220

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8.4.1 Market Drivers ................................................................................................................................. 220
8.4.2 Market Limiters ................................................................................................................................ 221
8.5 COMPETITIVE ANALYSIS ..................................................................................................................... 223
ORTHOPEDIC TENDON GRAFT MARKET .................................................................................... 227
9.1 INTRODUCTION .................................................................................................................................... 227
9.2 MARKET OVERVIEW ............................................................................................................................ 228
9.2.1 BTB ................................................................................................................................................... 228
9.2.2 Soft Tissue Grafts ............................................................................................................................. 228
9.2.3 Allografted Tendons ......................................................................................................................... 228
9.2.4 Ligament and Tendon Synthetic Grafts ............................................................................................ 229
9.3 MARKET ANALYSIS & FORECAST ....................................................................................................... 230
9.3.1 ACL/PCL Reconstruction Procedures .............................................................................................. 230
9.3.2 ACL/PCL Allograft Tendon Market ................................................................................................. 232
9.4 DRIVERS AND LIMITERS ...................................................................................................................... 234
9.4.1 Market Drivers ................................................................................................................................. 234
9.4.2 Market Limiters ................................................................................................................................ 235
9.5 COMPETITIVE ANALYSIS ..................................................................................................................... 236
ORTHOPEDIC CARTILAGE REPAIR MARKET ........................................................................... 239
10.1 INTRODUCTION .................................................................................................................................. 239
10.1.1 Anatomy .......................................................................................................................................... 239
10.1.2 Methods for Cartilage Repair ........................................................................................................ 240
10.1.2.1 Osteochondral Allograft Transfer ............................................................................................... 240
10.1.2.2 Autologous Chondrocyte Implantation (ACI) ............................................................................. 240
10.1.2.3 Meniscal Allograft Transplantation ............................................................................................ 240
10.2 MARKET OVERVIEW .......................................................................................................................... 241
10.3 MARKET ANALYSIS AND FORECAST ................................................................................................. 245

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10.3.1 Osteochondral Cartilage Allograft Market .................................................................................... 246
10.3.2 Meniscal Allograft Market ............................................................................................................. 247
10.3.3 Autologous Chondrocyte Implantation Market .............................................................................. 248
10.4 MARKET DRIVERS AND LIMITERS ..................................................................................................... 249
10.4.1 Market Drivers ............................................................................................................................... 249
10.4.2 Market Limiters .............................................................................................................................. 249
10.5 COMPETITIVE ANALYSIS ................................................................................................................... 251
SPINAL MACHINED BONE ALLOGRAFT MARKET ................................................................... 255
11.1 INTRODUCTION .................................................................................................................................. 255
11.1.1 Machined Bone ............................................................................................................................... 257
11.2 MARKET OVERVIEW .......................................................................................................................... 258
11.3 MARKET ANALYSIS & FORECAST ..................................................................................................... 261
11.3.1 Spinal Machined Bone Allograft Market by Segment .................................................................... 261
11.3.1.1 ALIF Machined Bone Allograft Market ...................................................................................... 262
11.3.1.2 PLIF Machined Bone Allograft Market ...................................................................................... 263
11.3.1.3 TLIF Machined Bone Allograft Market ....................................................................................... 264
11.3.1.4 CIF Machined Bone Allograft Market ........................................................................................ 265
11.4 MARKET DRIVERS AND LIMITERS ..................................................................................................... 266
11.4.1 Market Drivers ............................................................................................................................... 266
11.4.2 Market Limiters .............................................................................................................................. 267
11.5 COMPETITIVE ANALYSIS ................................................................................................................... 270
ABBREVIATIONS ................................................................................................................................. 273

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