pathogenesis of eka kusta

1. Effect of NavayasaRasayana
Lehaand MedhyaRasayana
tablet in the management of Ekkakushta(psoriasis).
Clinical study.
By: Dr.Rajimunnisa begum.sk
P.g scholar ,Dept.of k.c:
Guide : Dr.S.Ramalingeswar rao.M.D (Ayu)
16-Dec-14 1k.C dept

2. INTRODUCTION
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EPIDEMIOLOGY
PREVALENCE
MORTALITY &
MORBIDITY
GENDER&
AGE
INTERNATIONAL
RANKING
INTERNATIONAL
DISTRIBUTION
c
Causative factors

3. 16-Dec-14 k.C dept 3
CONT………..
What might be the comparison ?

4. OBJECTIVES &
CLINICAL PLAN
OBJECTIVES
OF THE STUDY
TO ASSESSES
THE
EFFICACY OF
1.NAVAYASA
RASAYANALEHA
2.MEDHYARASAY
ANA TABLET
CLINICAL
PLAN
3 PATIENTS
16-Dec-14 k.C dept 4
DURATION-3MONTHS

5. PARAMETERS
SUBJECTIVE
• Matsyashakala
• Aswedha
• Ruksha
• Kandu
• Daha
• Mandala
• Bahalatva
• Srava
• Unnati
OBJECTIVE
• Diagnosis was supported by
the following clinical tests.
• 1. Candle grease sign
• 2. Auspitz sign
• 3. Koebne phenomena
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6. CLINICAL PLAN
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•Diagnosis was supported by the
followingclinical tests.
•1. Candle grease sign
•2. Auspitz sign
•3. Koebner phenomen
DIAGNOSTIVC
CRITERIA
• 1. Age- 13-70 years
• 2. Cardinal symptoms of Ekkakushta.
chronicity less than 5yrs
• 3. Positive Signs of Psoriasis like
Auspitz sign, Candle grease sign etc.
INCLUSIVE
CRITERIA
• PATIENTS WITH MAJOR
SYSTEMIC ILLNESS
EXCLUSIVE
CRITERIA

7. DISEASE REVIEW
NIDANA,SAMPRAPTHI
PURVARUPA ,RUPA
CHIKITSA
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8. pathophysiology
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9. k.C dept 9
• The initiation and maintenance of lesions requires
activated T Lymphocytes
• Drugs suppressing T-cell activity contribute to the
improvement of psoriasis t of psoriasis activity contribute to
the improvement of psoriasis
16-Dec-14

10. HISTOPATHOLOGY
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14. Types of Psoriasis
1-Psoriasis Vulgaris(Plaque-type)
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2-Guttate Psoriasis

15. 2-Guttate Psoriasis
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16. 3-Inverse Psoriasis
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17. 4-Psoriatic erythroderma
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18. 5-Pustular Psoriasis
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19. 6-Sebopsoriasis
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20. 7- Napkin psoriasis
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21. NAIL CHANGES IN
PSORIASIS
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24. DRUGREVIEW
• Navayasa Rasayana (5gms bid)
• Leha is taken from the reference found in
Chakradatta It has the following ingredients
in increasing proportions - Dhatri, Aksha,
Haritaki, Vidanga, Chitraka,
Shuddha Bhallataka, Bakuchi, Loha
• Bhasma, Bhrungraj and Tila Taila
(Q.S). The fine powder of the drugs is to be licked
with Tila Taila at the time of drug
administration.
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25. CONT……………
Medhya Rasayana tablet ( 500mg 1 bid)
• Stress is the most crucial factor in onset
and progression of the disease
• Hence, Medhya Rasayana tablet is
Anubhuta Yoga (non-classical
formulation).
• It contains the following drugs in
increasing proportions-
• Vacha, Haritaki, Jatamansi, Jyotishmati,
Yashtimadhu, Shuddha Bhallataka,
Guduchi, Brahmi and Shankhpushphi.
16-Dec-14 k.C dept 25

26. Probable mode of action of
drugs in N.R leha
• Actions
• Immunomodulatory
• Antioxidant
• Adaptogenic
• Wound Healing
• Anti-inflammatory
• Anti-arthritic
• Antistress
• Drugs
• Amalaki, Haritaki, Bakuchi
• Amalaki, Haritaki,
Bhallataka
• Amalaki, Haritaki
• Haritaki,Amalaki
Bhallataka, Bakuchi,
Bhrungraj
• Bhallataka
• Bhallataka
16-Dec-14 k.C dept 26

27. Pharmacologically proven
actions of drugs of M.T
 Actions
• Sedative
• CNS depressant
• Anti-inflammatory
• Immunomodulatory
Antioxidant
• Antistress
• Adaptogenic
• Nootropic
• Drugs
• Sedative Vacha, Jyotishmati,
Shankpushpi
• Vacha, Jatamansi
• Jyotishmati, Yashtimadhu,
• Guduchi, Bhallataka
Yashtimadhu, Guduchi, Haritaki
Yashtimadhu, Brahmi, Haritaki
Yashtimadhu, Guduchi
Yashtimadhu, Guduchi, Haritaki
• Yashtimadhu, Guduchi, Brahmi,
Shankhpushpi
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28. RESULTS
GRADING
Matsya shakalalopam .asweda .daha, Ruksha other signs
PRESENT--------2
MPROVED--------1
ABSENT---------0
Mandala
NORMAL SKIN –0
FAINT OR NEAR TO NORMAL—1
Blanching + redness-2
No blanching + redness—3
Red color + subcutaneous---4
Kandu
No itching-------0
Mild itching------------1
Severe itching----------2
Very severe itching----3
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29. Statistical analysis of results
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SYMPTOMS & SIGNS B.T SCORE A.T SCORE
Matsya shakala 06 4
Mandala 12 8
Rukshas 06 2
Kandu 12 8
Daha 05 3
Asweda 04 2
Srava 8 4
Bahalatwa 7 3
Auspitz sign 6 3
Candle grease sign 5 3
Koebne phenomena 5 2

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Results No. of Patients Percentage
Good/complete
relief
2 75%
Moderate relief 1 25%
Poor/No relief 0 0

31. Before & After
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32. Before & After
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33. DISCUSSION
• Navayasa rasayanaleha has provided better relief
• in symptom of Matsyashakala,
Asvedanam,
• Rukshata, Koebner phenomenon and
Kandu
• On the other hand comparatively better
improvement in Mandala,
• candle grease sign and Daha.
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34. CONCLUSION
 Stress may lead to early onset of disease (maximum
patients-21-30 years) and early recurrence.
 Virrudhaashana is one of the predominant Nidana which
is also described by Acharya Charaka as cause of
Ninditavyadhies
 one among which is Kushtaroga.
 Maximum patients were depressed/ anxious- which clearly
shows the psychosomatic nature of the disease.
 Family history was positive in some of the patients,
suggesting a genetic cause of the disease.
 In the present study, it may be inferred that people of
Vata-Kapha Prakruti may be more susceptible to
Psoriasis. k.C dept
34
16-Dec-14

35. References
• VaraBehl PN, Agarval A and Shrivastava
Govinda:Practice of Dermatology.
• Cha Chi 7:21,39
• Su.Chi 9: 43,68
• Chakradatta :Kusta roga prakarana
• A.s 21:9
• A.h 19:31,32
• Etc...........
• 1999)
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