Rameshwar Dass

rules for creating data files nonmem data items list of built‐in models basic structure and execution parallel computing of a single nonmem half-life volume of distribution clearance pharmacodynamics clinical pharmacokinetics pharmacokinetics of drug inter in-vivo bioavailability data in-vitro–in-vivo correlations evaluation of modified-release transdermal patch transdermal drug delivery preformulation evaluation osmotic extended-release classification matrix system pharmacokinetic simulation kinetics of extended-release dosage form selection biopharmaceutic factors objectives modified-release drug products skin excretion salivary excretion enterohepatic cycling hemofiltration hemodialysis peritoneal dialysis dialysis extracorporeal removal dose adjustment in renal prob creatinine clearance estimated by measuring gfr factors affecting renal renal clearance and mechanism urine flow passive tubular reabsorption active tubular secretion glomerular filtration nephron renal excretion of drug biopharmaceutics multi-compartment models zero-order absorption model extra-vascular delivery loading dose intravenous infusion intravenous bolus mammillary model types of compartment models pharmacokinetic models qualities of a mathematical mathematical model two compartment model one compartment model compartment models in-vitro- in silico- in-vivo ivivc modeling issues in-vitro release profile flow chart of ivivc levels of iviv methods of ivivc parameters in ivivc level why require ivivc flow chart biopharmaceutical process plasma curve absorption factors affecting absorption mechanisms of drug absorption transport models