1. Proteus Venture Partners’ Network
Proprietary Access to Breakthrough Technology
March 2012

2. Worldwide Coverage of the Regenerative Medicine
Proteus Offices
Scientific Advisors
University Affiliations
Conference Presentations
Professional Organizations
CONFIDENTIAL 2

3. The Proteus Network: 7 Major Components
A deep network generates early access to breakthrough technology & innovation

4. Leveraging Key Opinion Leaders – US
* * *
*
*
*
*
* Core team or scientific advisory board member from these institutions

5. Leveraging Key Opinion Leaders – ROW
* *
*
* Core team or scientific advisory board member from these institutions

6. Professional Organizations & Advocacy Groups
*
*
*
*
* Core team or advisory board member part of these organizations

7. Conference Presentations / Publications
 84 speaking engagements worldwide at leading academic and professional conferences
over the past 3 years (core Proteus team)
 Core team and Advisors are peer reviewers in virtually all the major RM Journals:
Biomaterials, Blood, Cell + Cell Stem Cell + Cloning and Stem Cells + JAMA + Journal of Biomedical Materials
+ Journal of Experimental Medicine + Journal of Orthopedic Research + Journal of Tissue Engineering and
Regenerative Medicine + Nature + Nature Biotechnology + Nature Medicine + Nature Reviews Drug Discover
+ NEJM + PLOS-Biology + PLOS-Medicine + PNAS + Regenerative Medicine + Science + Stem Cells and
Development + Tissue Engineering
 Core team and advisors contributed directly to the following publications:
Books
Principles of Tissue Essentials of Stem Cell Handbook of Stem Cells
Engineering Biology
Stem Cells Now The Immortal Cell Stem Cells in Drug
Discovery
Stem Cells: Bench to Advances in Tissue Surfaces and Interfaces for
Bedside, Engineering Biomaterials
Reports
Advance cell & Tissue Therapies - A mission to the US, Guidance on Standards on methods and
regulation for cell-based therapeutics (British Standards Institute)
Regenerative Medicine Terminology (British Standards Institute)

8. Leverage Deep Domain Expertise of Partners
Cell Processing US & EU
and CRO / CMO Jon Rowley, David Smith & Kim Warren Intellectual
Property & Legal
Vern Norviel, Patent Attorney
Robert Preti, Stewart
John Robinson, CEO Craig, Lee Buckler
Chip Lion & David Riley: Fund Counsel
Matt Vincent, Patent Attorney
RM Specific James Lawford-Davies
Consulting
Steve Bengston
Tom Keelin & Michael Reeds:
Decision Analysis & Asset Valuation
Barry Frankel & Devyn Smith: Life Science & RM Regulatory
RM Business Consultants
Advice
Sofi Fexby, Pierre Maillet &
John Watkins
Shankar Seetharaman, CEO
Peter Johnson Darin Weber: FDA & Regulatory Issues
(CBER)
CONFIDENTIAL 8

9. Leverage Venture Capital Relationships
CONFIDENTIAL 9

10. Leverage Proteus’ Proprietary Databases
Three Core Databases: RM Companies, Academic Research, IP

11. Appendices
Details of Proteus’ Network of Relationships and Publications
1. Academic & Research Organizations: US and ROW
2. Professional Organizations & Advocacy Groups
3. Funding and Regulatory Agencies
4. Conference Presentations and Publications

12. Academic & Research Organizations: US – Team Contacts
Organization Contact
Brown University Michael Lysaght
Burnham Institute for Medical Research Evan Snyder
Children’s Hospital Oakland Research Institute Bertram Lubin
Columbia University Silviu Itescu
Duke University Nelson Chao, Diane Kurtzberg, Bob Taber
Emory University Edmund Waller
Harvard University George Daley, Brock Reeves, David Scadden , Amy Wagers, Charles Vacanti
Johns Hopkins University Gary Brocker, Doug Kerr, Aristides Melissaratos, Jeff Rothstein
Massachusetts Institute of Technology (MIT) Myron Spector, Lita Nelsen, Ioanis Yannas, Robert Langer, Fiona Murray
McGowan Institute – UPMC Alan Russell, Eric Lagasse
MD Anderson Cancer Center Krishna Komanduri, Jeff Molldrem
Memorial Sloan Kettering Cancer Center Malcolm Moore
Stanford University Amato Giaccia, Geoffrey Gurtner, Michael Longaker, Irving Weissman
U of Texas: Texas Heart Institute Paul Simmons, Emerson Perin, James Willerson
UC San Francisco Arnold Kriegstein, Yerem Yeghiazarian, Emmanuel Passague
University of Florida-Gainesville Dennis Steindler
University of Michigan Steve Feinberg, Wayne Harvey, Sean Morrison
University of Pennsylvania George Cotsarelis,
University of Washington Shelly Heimfeld, Don Thomas, Reiner Storb, Phil Greenberg
University of Wisconsin-Madison Jamie Thompson, Gabriela Cezar, Lynn Allen-Hoffmann
Wake Forest University Anthony Atala

13. Academic & Research Organizations: ROW – Team Contacts
Organization Contact Organization Contact
A*Star (Singapore) Alan Colman University College of London (UK) Chris Mason
Babraham Institute (UK) Wolf Reik University of Cambridge (UK) Roger Pederson, Azim Surani
Imperial College London (UK) Julia Polak University of Edinburgh (UK) Ian Wilmut
King's College London (UK) Stephen Minger University of Oxford (UK) Paul Fairchild
Monash University (Australia) Richard Boyd University of Southampton (UK) Richard Oreffo
The University of Nottingham (UK) Kevin Shakesheff University of Toronto (Canada) Gordon Keller, Vince Tropepe
Yair Reissner, Yoav Soen,
The University of Sheffield (UK) Peter Andrews Weizmann Institute of Science (Israel)
Tzvi Lapidot

14. Professional Organizations & Advocacy Groups
Organization Team Involvement
Advisory Board, Finance Committee, Industry Committee, Global
International Society of Stem Cell Research (ISSCR)
Forum (Organizer)
International Society for Cellular Therapy (ISCT) Commercialization Committee
Tissue Engineering & Regenerative Medicine Society International (TERMIS) Past President
Working Relationship (Alan Lewis, Dick Ensel, Robert Goldstein, Julia
Juvenile Diabetes Research Foundation
Greenstein, Peter Lomedico, Charlie Queenan)
Harvard Stem Cell Institute Executive Director
Stem Cell Network (Canada) Advisor
UK National Stem Cell Network (UKNSCN) Founder, Steering Committee
East of England Stem Cell Network (UK) Founder
London Regenerative Medicine Network (LRMN) (UK) Founder/CEO/Trustee
Centre of Excellence for Life Sciences – Newcastle (UK) Advisor
Ministry of Defence, Defence Society and Technology Laboratory (UK) Advisor
UK Department of Health – UK Stem Cell Initiative Consult/Contributor

15. Funding and Regulatory Agencies
Agency Contacts
USA
FDA - CBER Donald Fink, Celia Witten, Steven Bauer
California Institute for Regenerative Medicine Alan Trounson, Robert Klein
National Institutes of Health Ron McKay, Jefferey Barker
UK
MHRA (UK) Jeremy Tinkler, Chris Bravery
Mike Low, Regenerative Medicine Standards Committee
British Standards Institute (BSi)
(PAS 83/84)
LGC (formerly Laboratory of the Government Chemist) Julian Braybrook, Neil Harris
National Physical Laboratory (NPL) Kamal Hossain, Mark Bailey, Markys Cain, Peter Tomlins
UK Stem Cell Bank (Nat. Instit. for Biological Stds + Control [NIBSC]) Glyn Stacey, Charles Hunt, Lyn Healy

16. Conference Presentations
Conference Year(s) Team Involvement
American Society of Bone Marrow Transplantation (ASBMT) 2005-2008 Member, Speaker
American Society of Hematology (ASH) 2005-2008 Member, Speaker
BIO International Convention 2007, 2008 Speaker
bioprocessUK Conference 2006 Speaker
Bioproduction 2006 2006 Keynote speaker
Cambridge University Technology and Enterprise Club (CUTEC) Technology Ventures
2007 Panel Member
Conference
Commercial Translation for Regenerative Medicine 2007 Organizer, Keynote Speaker, Scientific Advisory Board + Meeting Chair
Commercialisation of Tissue Engineering & Regenerative Medicine Conference 2005 Conference Chairman, Scientific Advisory Panel
Commercialization of Tissue Engineering and Cell Therapy 2006, 2007 Event Chair and adviser
Congress of International Drug Discovery Science and Technology (IDDST) 2007 Scientific Advisory Board
ESACT-UK Annual Meeting 2006 Session Chairman and organiser
EU Marie Curie Conference 2007 Organising Committee
2006, 2007, Originator, Organizer, Keynote Speaker, Scientific Advisory Board +
European Stem Cell & Regenerative Medicine Congress
2008 Chairman
EuroSciCon 2005 Speaker
Genesis Conference 2005 Session Chairman, Advisory Panel
International Stem Cell Conference 2007 Speaker

17. Conference Presentations
Conference Year(s) Team Involvement
ISCT Annual Meeting 2007, 2008 Speaker
ISSCR Annual Meeting 2007 Speaker
Kellogg Business of Healthcare Conference 2008 Speaker
Medical Device Technology European Conference 2005 Guest speaker
National Stem Cell Conference (UK) 2005 Speaker
Netherlands Science & Technology Conference 2006 Speaker
Phacilitate Cell & Gene Therapy Forum 2008 Speaker
Stem Cells & Regenerative Medicine Conference 2006, 2007 Speaker
2005, 2006,
Stem Cells & Regenerative Medicine Congress Speaker
2007
STEPS: Stem Cell Therapy as an Emerging Paradigm in Stroke 2007 Keynote
Strategies for Engineered Negligible Senescence (SENS) 2007 Session Chair
The International Conference on Advanced Laser Technologies 2003 Speaker
The Stem Cell Congress 2007, 2008 Speaker
Tissue Engineering & Regenerative Medicine Society International (TERMIS) 2007 Speaker
World Congress on Regenerative Medicine 2007 Organizer, Keynote Speaker, Advisory Board, Session Chair
World Stem Cell Summit 2007 Speaker

18. Conference Presentations
Workshops/Symposia Year(s) Team Involvement
Advanced Medical Technologies Enterprise Florida (eFlorida) Mission to UK 2006 Session Chair
Anatomical Society of Great Britain & Ireland Summer Meeting 2007 Speaker
BA Festival of Science 2006 Speaker
BBSRC “The Cell Supply Chain Workshop” 2005 Conference co-organizer and Session Chairman
BIA Roundtable 2007 Speaker
BioIndustry Association (BIA) Regulatory Affairs Committee (RAAC) 2006 Session Chair
bioLogic USA 2005 Speaker
Bionanotechnology and Tissue Engineering Meeting 2003 Speaker
BIOS (Research Centre for the study of Bioscience, Biomedicine, Biotechnology and
2007 Speaker
Society) Public Debate
Brainy Brave New World public meeting 2007 Panel Member
British Standards Institute/Department of Trade and Industry Workshop 2005 Co-organizer and Chairman
British-Russian Workshop in association with the European Commission on Stem Cells 2007 Advisor, Speaker
Cheltenham Science Festival 2007 Panel Member
Cross Council Stem Cell Programme Grant-holder’s Workshop 2006 Speaker
DTI funded Global Watch Mission, “Advanced Cell & Tissue Therapies - a mission to the
2006 Speaker
US”
Economic and Social Research Council (ESRC) Stem Cell Programme 2007 Speaker
IChemE - Biochemical Engineering Subject Group 2006 Speaker
London Biotechnology Network Workshops 2006 Event Chairman and adviser
London Technology Network Workshops 2007 Session Chair
McGowan Institute Retreat 2007 Speaker

19. Conference Presentations
Workshops/Symposia Year(s) Team Involvement
Mid-Atlantic Bio, Stem Cell Track 2007 Speaker
Presentation to National Physical Laboratories and LGC (Laboratory of the Government
2004 Speaker
Chemist)
Regenerative Medicine Workshop - UK-Medicon Valley Bioscience Collaboration 2007 Session Chair
Rolduc International Polymer Meeting (European Polymer Federation) 2003 Keynote speaker
Royal Institution of Great Britain, Friday Evening Discourse 2007 Speaker
Silicon Valley Chapter of the National Association of Corporate Directors 2008 Moderator & Speaker
Stem Cell Manchester 2007 Speaker + panel member
Stem Cell Roundtable, Science and Innovation 2007 Speaker
Stem Cells for Tissue Engineering and Regenerative Medicine to Policy 2006 Speaker
Stem Cells in Orthopaedics Meeting 2005 Speaker
Symposium in Stem Cell Repair and Regeneration 2006, 2007 Session Chair + Co-organizer
The 2007 Hunterian Lecture 2007 Speaker
The Stem Cell Partnering Series 2008 Speaker
The Stem Cell Summit 2007 Speaker
The Wolfson Centre for Age-Related Diseases and the King’s College London Stem Cell
2005 Speaker
Consortium
Tissue Engineering And Regenerative Medicine Workshop 2004 Speaker
Tissue Engineering Meeting, DTI Texas-UK Collaborative Bioscience Initiative 2005 Presenter
UCL Lunch Hour Lecture 2007 Speaker
UK Focus for Biomedical Engineering Committee (hosted by the Royal Academy of
2007 Speaker
Engineering)
University of Sydney/UCL Frontiers of Knowledge Symposium 2007 Speaker

20. Publications
Publication Team and Advisors Involvement
Regenerative Medicine (Journal) Founder, Editor
Tissue Engineering (Journal) Editorial Board
Principles of Tissue Engineering, 2nd Edition (Lanza, et al.) Contributing Editor
Essentials of Stem Cell Biology (Lanza, et al.) Contributing Editor
Handbook of Stem Cells, Volumes 1 & 2 (Lanza, et al.) Contributing Editor
Stem Cells Now (C.T. Scott) Author
The Immortal Cell (M.D. West) Author
The Proteus Effect (A. Parsons) Contributor
Stem Cells: Bench to Bedside (Bongso & Lee) Contributing Author
Advanced cell & tissue therapies - A mission to the US (DTI Global Watch Mission Report) (C. Mason, et al.) Editor, Co-Author
PAS 83 - Guidance on standards, standardised methods and regulation for cell-based therapeutics, from basic
Co-Author
research to clinical application (British Standards Institute)
Advances in Tissue Engineering (J. Polak, ed.) Contributing Author
Surfaces and Interfaces for Biomaterials (P. Vadgama, ed.) Contributing Author
Stem Cells in Drug Discovery: Applications as Tools and Targets (C. Mason, et al.) Co-Author
PAS 84 - Regenerative Medicine Terminology (British Standards Institute) Co-Author
Various Peer Reviewed Publications Including Cell, Science, PLoS and others

21. Publications
Scientific Journals – Peer Review Participation (Team and Advisors):
Biomaterials Nature Biotechnology
Blood Nature Medicine
Cell Nature Reviews Drug Discovery
Cell Stem Cell New England Journal of Medicine
Cloning and Stem Cells PLOS-Biology
JAMA PLOS-Medicine
Journal of Biomedical Materials PNAS
Journal of Experimental Medicine Regenerative Medicine
Journal of Orthopedic Research Science
Journal of Tissue Engineering and Regenerative Medicine Stem Cells and Development
Nature Tissue Engineering