19. Hgb CC Crystal
Rhomboid, tetragonal or rod shaped, crystals of dense
staining
After splenectomy
CS= Homozygous Hb SC Dse
20. BLISTER CELL
Red cell w/ single or multiple vacuoles or markedly
thinned areas at the periphery
Pre-cursor of helmet cells
Microangiopathic Hemolytic Anemia
21. DEGMACYTE (BITE CELL)
Drug-induced anemias
G6PD Def., Thalassemia,
Happened due to passing through the blood
vessels of the spleen some parts of the cell
remains
22. BASOPHILIC STIPPLING
Fine= Inc. polychromatophilia
Blueberry bagel appearance
CS= Lead poisoning (Plumbism), Impaired Hgb
synthesis, MA
Remnants of RBC RNA
23. HOWELL JOLLY BODIES
Single: nuclear chromatic remnants, MA, HA
Double: MA, Abnormal Erythropoiesis
Large single inclusions
Related to DNA remnants
24. PAPPENHEIMER BODIES
SIDEROTIC GRANULES
SMALL DARK BLUE PURPLE
PRUSSIAN BLUE= Staining non-heme iron granules
WRIGHTS STAIN= Faint blue
Granules clumped together
CS= Sideroblastic
anemia, Hgbinoathies, Thalassemia, MA, myelodysplatic
syndrome
25. CABOT RINGS
Ring shape, figure of 8
Double or several concentrics
Microtubules remnants or mitotic spindle
Rarely seen in PA, lead poisoning
Abnormal erythropoiesis
26. HEINZ BODIES
Denatured Hgb
Residues of oxidized Hgb
Presence in indicative of RBC injury
w/ alcoholism
G6PD def, unstable Hgb
27. Hb H INCLUSIONS
“GOLF BALL
DENTS”
Multiple blue
green spherical
inclusins
stained with
Brilliant Cresyl
Blue (BCB)