This document provides information about how to become a scientist and details the career of Prof. Dr. V. Samuel Gnana Prakash. It discusses his educational background, prestigious international fellowships received, positions held promoting international scientific collaboration, and vision to establish biomedical research institutions in India through partnerships like BRICS Biomed. The professor has over 25 years of experience in biotechnology research and aims to foster innovation and startups to advance biomedical sciences through global collaboration.

1. How to become a Scientist
Prof. Dr. V. Samuel Gnana Prakash
DAAD Fellow (Germany)
EMBO Fellow (Germany)
MARIECURIE Fellow (EU)
FOCAL POINT – European Commission H2020
CHAIRMAN ASSOCIATE – BRICS BIOMED
Prof and Head of the Department
Centre for Marine Science and
Technology (CMST)
Manonmaniam Sundarnar University
Rajakamangalam. Kanyakumari Dist.

2. Biodiversity Hot spot – Kannyakumari
1 of 5 in India
800 types of Herbs
30 types of Banana
Top Honey Producers in India – more flowers

3. High Profile International Positions holding at present
European Commission
HORIZON2020
HORIZON2020 is a 80 Billion Euro research funding programme (2014-2020) of the European Commission. To
foster Indo-EU research collaborations, about 30 FOCALPOINTS (top ranking Indian scientists, who had already
taken up projects from European Commission with EU scientists) are chosen by European Commission to foster
Indo-EU collaborative works. Since Aug. 2014, I am serving as FOCAL POINT and had organised one EU event
and gave 6 talks on HORIZON2020, mooted a collaborative event on FUTURE INTERNET. Since Dec.2015, I
am deputed as Coordinator of FOCAL POINTS.
Positiontill 2020
Coordinator of FOCAL POINTS

4. High Profile International Positions holding at present
Chairman Associate
To foster research collaboration within Brazil, Russia, India, China and South Africa (BRICS), a BRICS Biomed
Cooperation has been formed. This has been initiated by Russian Government, having nominated Prof. Shamil
Akamedov from Russia as its Chairman. In an International selection, four Chairman Associates, each one from
Brazil, India, China and South Africa has been selected. Myself selected as Chairman Associate of India in
Oct.2014. A call (application) for research proposal has been sent to Indian Scientist and I had received about
120 research proposals to be funded. Establishment of Advisors for BRICS Biomed (India) and establishment of
project proposal evaluators is being done currently.
Positiontill 2021
Indo-Russia delegation meeting At Tomsk, Russia – May
18,2015
Myself presenting proposal
on BRICS Biomed – India,
for research and
Infrastructure funding to
India. On the evening
dinner hosted by the
Ambassador HE P.S.
Raghavan, complimented
me that I made a very
good presentation
Delegation Head,
His Excellency P.S Raghavan,
Ambassador of India in Russia
Four Russian television media covered the event, one is
https://www.youtube.com/watch?v=eENA9Hr8R3o

5. Four Prestigious International Fellowships received
1. DAAD Fellow (Biotechnology), 1994
German Akademic Exchange Fellow, selected by DAAD, Bonn,
Germany and Ministry of Human Resource Development
(MHRD), Govt. of India for carrying out part of Ph.D work in
University of Bonn, Germany (1994 to 1996). Revisit grant in
2001
2. UNESCO Biotechnology Fellowship ,2001
Selected by UNESCO Biotechnology Action Council for training
in Biotechnology at University of Bari, Bari, Italy
3. EMBO Fellow, 2002
Selected by European Molecular Biology Organisation (EMBO)
as World programme Fellow, to carry out research in Molecular
Biology at Carl von Ossietzky Universität, Oldenburg, Germany
for nine months. One among the four fellows selected.
4. MARIECURIE Fellow, 2004
Selected by European Commission as Mariecurie Fellow and
awarded individual project on DNACHIP(Nanobiotechnology)
for 2,13,522 Euros (Rs. 1.24 Crores) to carry out the project at
European Molecular Biology Laboratory, Heidelberg, Germany
(Nov. 2004 to Oct. 2006).
EMBO Fellow
Germany
Mariecurie Fellow
DAAD Fellow
Germany
UNESCO
Fellowship, Italy

6. Visits Abroad
Countries visited
Purpose Duration From To
1 Germany
Switzerland
DAAD Fellow
Research 9 months 06.04.1994 04.03. 1995
2
Germany
France
Belgium
DAAD Fellow
Research
7 months 08.07. 1995 24.01. 1996
3 Thailand
(Bangkok)
World Aquaculture
Conference ‘96 1 week 28.01. 1996 04.02. 1996
4 Germany Belgium
France DAAD Fellow
Research
7 months 19.06. 1996 26.12. 1996
5
England
Scottland
(Edinburgh)
1 st U.K Marine Biotechnology
Conference 1 week 19.08. 1996 26.08. 1996
6 Germany DAAD Revisit Programme
2 months 04.10.2001 28.11. 2001
7 Italy
Austria
UNESCO Fellowship in
Biotechnology 1 month 29.11. 2001 24.12. 2001
8 Belgium European Research 2002 (FP6) 2 weeks 8.11. 2002 24.12. 2002
9 Germany EMBO Fellow 9 months 25.11. 2002 26.07. 2003
10 France Indo-French Nanobiotechnology &
Genomics Meet 1 week
08.10. 2004 10.10. 2004
11 Greece Training Programme on Methods in
Micro-Nanotechnology and
Nanobiotechnology
1 week 06.06.2005 10.06.2005
12 Germany Mariecurie Fellow 24 months 15.12. 2004 25.11.2006
13 Singapore Higher Education Summit 2 days 27.10. 2009 29.10. 2009
14 Russia BRICS Biomed Meeting 7 days 15.6.2015 22.5.2015

7. In 1994, during my Ph.D research at
University of Madras, Guindy Campus, I
was selected as the topper in field of
Biotechnology by Ministry of Human
Resources Management, Govt. of India
as DAAD Fellow (German Academic
Exchange Fellow). I carried out my Ph.D
work at University of Bonn, Germany.
During my two and half years of Stay in
Germany, I had learnt many advanced
techniques. For a short time I had worked at
the German Aerospace research Centre,
Koln. This gave me an opportunity to look at
my mother land in a different perspective.
After my Ph.D research, I wanted to come
back to India and play my role in the
development of India. In 1997, I joined as a
lecturer in Manonmaniam Sundaranar
University.
Univ. of Bonn, Germany
DLR, German Aerospace Research Centre, Koln

8. Tamilnadu has high Intellectual capital and India has high
Biodiversity (particularly Kannyakumari District). In 2001, I had
written a Department of Biotechnology,
Govt of India to establish a Indian
Institute of Biotechnology. Again in
2001 I visited Germany in a DAAD
revisit programme. During this period I
worked at University of Hamburg.
.During my European visits I used to
go around Universities and visit
different cities to understand more
about their development.
In 2001, I was selected to receive UNESCO
Fellowship In Biotechnology. I had training for a
month (Nov,2001) in University of Bari, Italy on
Mitogenomics. A complete training on
sequencing of whole mitochondrial genomes
was obtained.
University of Bari, Italy

9. In 2002, I was made as the Coordinator of Nanobiotechnology
Programme of Manonmanaim Sundaranar University. At this time
through internet I came to know that the
European Union is going to inaugurate one of
its high profile research funding programme
the Sixth Frame Work Programme (FP6) with
a research budget of 17 Billion Euros at
EU, Brussels. I decided to participate in the
programme to understand the perspective of
Research in Europe. Eight thousand
scientists from all over the world participated
in the three day event. I participated in the
programme by self sponsorship. I came in
contact with many scientist and after the FP6
programme , I visited the European Commission office three days to
have more interaction.
In Aug 2002, I was selected as an EMBO Fellow, (European
Molecular Biology Organisation) to carry out research in
Biotechnology. In a global level
competition, I was one among the four
young scientist invited to carry out my
research at an European University,
University of Oldenburg, Germany. I
was getting trained at different
Universities in Europe.
University of Oldenburg, Germany

10. During my stay at Belgium, I was
invited to deliver a lecture at
University of Leuven, Belgium. This
gave a very good boost to my idea. I
could understand the different
programme of the EU.
University of Leuven, Belgium
In 2004, I competed for the prestigious
MARIECURIE FELLOWSHIP of the European
Commission Sixth Frame Work Programme
(FP6). For young scientist around the globe
this is a challenging fellowship with a funding
of quarter a million USD. My project got grade
‘A’ and was funded. Probably I am the first
MARIECURIE FELLOW from India.

11. I was invited to delivery a lecture at Sophia-
Antipolis Research Park at Niece, France.
This gave me an overview of the
functionalities of a research park. I was part
of a 20 member delegation from India to
France.
From 2004 – 2006, I carried my research at
European Molecular Biology Laboratory,
Heidelberg, Germany. EMBL is the top
Institute in Europe with more than 800
scientist from 60 Nationalities. At EMBL
I understood how scientist can
mutually collaborate to bring out world class
products. I could hit upon the different winning
strategies in an European Institute.
Sophia-Antipolis Research Park , France
EMBL, Germany

12. Aug. 2014, Dr. S.G. Prakash Vincent appointed
as FOCALPOINT for Horizon 2020, the 70 Billion
Euro Research funding programme of the
EuropeanCommission (2014-2020).
In Oct. 2014, Dr. S.G. Prakash Vincent started
AIC as a Research and educational nonprofit
trust to foster International collaborations.
In Sept 2014, Dr.S.G.Prakash Vincent
Appointed at Chairman Associate (India)
For BRICS Biomed Cooperation
Jan 2015, receiving NRI Award from
HE Mr. Michael Steiner Ambassador of
Germany and Mr. Anand Sharma, Minister
for Civil Aviation in the presence of British
Deputy High Commissioner at Delhi.

13. What I am looking for
To establish 1000 Biomedical Scientists
In Kannyakumari District by 2025.
100 Biomedical Startups
In Kannyakumari District
How you can be part of it….

14. Indo- Russian meeting at
Tomsk, Russia – May 2015

15. BRICS countries have
40% Global market
Strategies of
VISION and MISSIONS
Biomed Cooperation
Dr.S.G.Prakash Vincent
Chairman Associate (India)
BRICS Biomed Cooperation
Establishment of Five Technology Transfer Centres in BRICS
Support from New Development Bank of BRICS
Why ?
How ?
Benefits !

16. Anti- Cancer drug - HERCEPTIN
2000 USD/month
100 USD/month ?
Anti-cancer drug for
1. Affordable Medicines - Diagnostics
2. Novel Medicines - Diagnostics
Roche signs $750 million deal for a beta-lactamase inhibitor2015
Single molecule OP0595
My labs work in this line…..
BRICS – Drug Discovery Networking Project – Networking -25 research groups from BRICS
Biomed
Cooperation
Aims at
Rajesh Lab – 20 molecules
100 molecules
100 m USD investment
1 molecule

17. Biotherapeutics is expected to reach 250 billion USD by 2020
Biosensors Market is Expected to Reach USD 18.9 Billion Globally in 2018
Global Medical Imaging Market To Reach $34 Billion In 2017
Cellular Technologies : It is expected to grow to a $15 billion market by 2015
Global Drug Discovery Technologies Market Surges to $118 billion by 2020
Global Lab-on-a chip Market is expected to become a USD 14.49 billion by 2018
Global Medical Robotic Systems Market is Expected to Reach USD 13.64 Billion by 2018
Bioinformatics Market Expected to Reach USD 30.8 Billion Globally in 2020
The total market for Nanobiotechnology products market size of $29.7 billion by 2015.
The global Nanomedicine market is expected to grow to $130.9 billion by 2016
Global Computational Biology Market Expected To Reach USD 4.2 Billion
$232 Billion Personalized Medicine Market to Grow 11 Percent Annually
Point-Of-Care Diagnostic Market worth $27.5 Billion by 2018
Global Regenerative medicine market expected to reach $67 billion by 2020
Global Stem Cells Market is Expected to Reach USD 170.15 Billion by 2020
Synthetic Biology : This market is expected to grow to $11.8 billion in 2018
Global market for tissue engineering & regeneration products to grow to $89.7 bn by 2016
Global Opportunities in Biomed 1258 Billion USD by 2020
BRICS Biomed Project Proposal:
Aiming at innovation,
Patenting, Product development and Starups/Spinoffs
2015-2021
5 Billion USD Investment
50 Billion USD returns expected
4 % of Global market of 1258 Billion USD

18. AIC Campus, 160 acres
BRICS Special Economic Zone
and Six Institutions to be placed
Arabian Sea
1
2
3
4
5
InternationalAirport
Trivandrum (TRV) is 70 kms
From AIC Campus
The Western Ghats are a mountain range
that runs almost parallel to the western
coast of the Indianpeninsula, located
entirely in India. It is a UNESCO World
Heritage Site and is one of the eight "hottest
hotspots" of biological diversity in the world
Drugs from Herbal Biodiversity
Marine Biodiversity
At the base of

19. Establishment of BRICS Biomed Centre in India (BBC)
Biomed is a diverse research area covering more than 20 disciplines. The market forecast for one of the
Biomedical areas, Stem Cell Technology is 180 Billion USD in four years. In this context, active collaboration
between BRICS would see that world class product in Biomed area is delivered from BRICS BBC. Out of the
total world population 42% is represented by the BRICS population. BRICS have the market within it. To
improve strong and active collaboration the project proposal in Biomed areas has been called for in BRICS
countries. To network the active research groups and bring the elite of them into the same campus for
Collaboration / joint innovation, it is being proposed to establish a BRIC Biomed Centre (BBC) at Alliance de
International Cooperation ( AIC) campus of 160 acres, Rajakamangalam, Kannakumari, at the sotthern tip of
India, facing the Arabian Sea. Dr.S.G.Prakash Vincent. Chairman Associate of BRICS Biomed Cooperation is
the President of Alliance de International Cooperation (AIC).
Model of BRICS Biomed Centre No of Floors = 25
No of labs = 200 nos
One Floor = 10 Labs
Common Labs in 4 floor,
1 Offices Floor
Total Area = 2000 sq.mts
x 25 floors = 50,000 sq.mts
Cost of Building = 30 Million USD
Cost of Common Instruments in 4 floors = 40 million USD
Maintenance for 10 years = 5 Million USD
Total = 75 Million USD
Total number of Scientific
persons To innovate
in BBC = 1800 persons
Non Scientific person = 200 nos

20. Establishment of BRICS Startup-Spinoff Centre (BSsC)
BRICS Biomed Centre would harbor
about 200 research groups. Another
200 research groups will be spread
across India. The total Indian BRICS
academic project is expected to
deliver about 1050 startups. All these
startups will be incubated in the
BSsC. This will also have the Patent
office, Venture Capitalist Networking
Office etc.
Also, the Biomedical, Biotech,
Pharma firms in BRICS countries
will be invited to make spinoffs
through the BSsC. This will bring
more interaction between all
BRICS and would see that in the
years to come world class products
would be coming out of the BSsC.
Model of BSsC
No of Floor = 25
No of spin off labs = 400 nos
One Floor = 10 Labs
Common Labs in 4 floor, Offices
= 5 Floor
Total Area = 2000 sq.mts x 25
floors = 50,000 sq.mts
Cost of Building = 30 Million USD
Maintenance for 10 years = 5 Million USD
Total number of Scientific persons
be using BSsC = 1500 persons
Non Scientific person = 200 nos

21. Establishment of BRICS International Convention Centre (BICc)
The BRICS Biomed Centre,
BRICS Startup-Spinoff
Centre (BSsC), AIC 20
International Centre , When
fully functional in the AIC
campus will have about 4000
scientific personals. It is
expected that 12 Major
International Conference, 12
Major Trade Shows and more
than 50 smaller events will be
executed at the proposed
BRICS International
Convention Centre. Every
years this would be hosting
place for more than 10,000
BRICS citizens.
Main Hall
5000 seats
Sub Hall 1 - 2000 seats
Sub Hall 2 - 2000 seats
Budget – 40 Million USD

22. 4. BRICS International Scientists Guest House
5. BRICS International Students Guest House
Model Building
About 400 Scientist will be working in
BBC and BScC . 400 apartments will be
built as above to accommodate them.
1600 Ph.d students will be involved in
BRICS related projects in BRICS
campus. And 1600 individual
apartments with International Standards
will be provided to them.

23. Special
Economic
Zone
RajakamangalamCampus, INDIA
BRICS- 725 Million USD
(NBD/ Investors)
AIC - 170 Million USD
GOI – 130 Million USD
Total = 1025 Million USD
Deliverables
Practical example of make in India
With Scientists from BRICS
10 x Return on Investment expected
1050 Startups/Spinoff in 5 years
3600 High value Patents
Affordable Medicine for BRICS
Novel Medicines/Diagnostics from BRICS
To Fund > 1000 projects
Budget Outlay

24. 633 Universities
Thankyou
Dr.S.G.Prakash Vincent
Chairman Associate (India)
BRICS Biomed Cooperation

25. M.Sc Research
Based programme
Aiming @
2 publications
1 patent
All will be guided to do Ph.D programme
India/ Europe/ Rest of the world
Another
100 Ph.D
opportunities
All 25 will be guided
to do Ph.D
Post doctoral Studies Scientist

28. Lab at CMST

29. Biotherapeutics is expected to reach 250 billion USD by 2020
Biosensors Market is Expected to Reach USD 18.9 Billion Globally in 2018
Global Medical Imaging Market To Reach $34 Billion In 2017
Cellular Technologies : It is expected to grow to a $15 billion market by 2015
Global Drug Discovery Technologies Market Surges to $118 billion by 2020
Global Lab-on-a chip Market is expected to become a USD 14.49 billion by 2018
Global Medical Robotic Systems Market is Expected to Reach USD 13.64 Billion by 2018
Bioinformatics Market Expected to Reach USD 30.8 Billion Globally in 2020
The total market for Nanobiotechnology products market size of $29.7 billion by 2015.
The global Nanomedicine market is expected to grow to $130.9 billion by 2016
Global Computational Biology Market Expected To Reach USD 4.2 Billion
$232 Billion Personalized Medicine Market to Grow 11 Percent Annually
Point-Of-Care Diagnostic Market worth $27.5 Billion by 2018
Global Regenerative medicine market expected to reach $67 billion by 2020
Global Stem Cells Market is Expected to Reach USD 170.15 Billion by 2020
Synthetic Biology : This market is expected to grow to $11.8 billion in 2018
Global market for tissue engineering & regeneration products to grow to $89.7 bn by 2016
Global Opportunities in Biomed 1258 Billion USD by 2020
BRICS Biomed Project Proposal:
Aiming at innovation,
Patenting, Product development and Starups/Spinoffs

30. Once Startups

51. @ CMST we will teach you how to start a company of your own…

52. @ CMST we will network with CMST alumni from 17 countries…

53. Dr. V. Samuel Gnana Prakash
DAAD Fellow (Germany)
EMBO Fellow (Germany)
MARIECURIE Fellow (EU)
Linked In : prakash.icn@gmail.com
9442428248
FOCAL POINT – European Commission
Chairman Associate – BRICS Biomed Cooperation
Welcome to CMST

56. Discovery of novel Antibiotics and Targets
Dr.S.G.Prakash Vincent - Lab
Methicillin resistant Staphylococcus aureus

57. Methicillin resistant Staphylococcus aureus
MRSA – getting
resistant to
almost all antibiotics

58. A drug is a molecule
that interacts with a biological molecule
triggering a physiological effect.
Hit/Lead
Target

59. Drug Discovery
@ ICN
Hit/Lead
Target
15 years
1 drug 18000 crores
Beta-lactamase screening
Whole cell MRSA
Zebrafish Infection models
Zebrafish Neuroactive models

60. Targets

62. Pathways in a single CELL

63. Bacterial targets …
1 new target is worth
minimum
100 million USD
Target
Should be highly unique ……
not similar to any human proteins
Proteins present in
pathogenic bacteria to
which a antibiotic binds and
Kills the bacteria

64. Cell wall synthesis
To counter act Bacteria produces Beta lactamase and chops off beta lactam
Antibiotics like pencillins, cephalophorins etc….
Screening novel antibiotics …..Beta lactamase inhibitors are novel antibiotics
@ ICN

65. Targets Pathways affected
Topoisomerase II
(DNA gyrase),
topoisomerase IV
DNA replication, SOS
response, cell division,
ATP generation, TCA
cycle, Fe–S cluster
synthesis, ROS formation,
and envelope and
redox-responsive
two-component systems
Targets Pathways affected
DNA-dependent
RNA polymerase
RNA transcription, DNA
replication and SOS
response

66. Cell wall synthesis
Targets Pathways affected
Penicillin-binding
proteins
Cell wall synthesis, cell
division, autolysin activity
(regulated by LytSR–VncRS
two-component system),
SOS response, TCA cycle,
Fe–S cluster synthesis,
ROS formation,
and envelope and
redox-responsive
two-component systems

67. Protein synthesis
Targets Pathways affected
30S ribosome Protein translation
(through inhibition of
aminoacyl tRNA binding
to ribosome)
Targets Pathways affected
50S ribosome Protein translation
(through inhibition
of elongation and
translocation steps) and
free tRNA depletion

68. Drug Discovery Process at ICN, Kannyakumari
1. Extraction of drugs
2. Partial Purification
3. Purification
4. Molecular Weight determination
5. Structural Characterization
Soxhlet apparatus
Thin Layer Chromatography
High Performance Liquid Chromatography
Mass Spectroscopy
Nuclear Magnetic Resonance
Spectroscopy
Hit/Lead

69. 1. Extraction of drugs Soxhlet apparatus
H E MDiscovery of novel Anti-infectives
Anti-MRSA assay

70. types of interactions
included ion-dipole,
dipole-dipole, hydrogen
bonding, dipole-induced
dipole, and Van Der
Waals forces
2. Partial Purification Thin Layer Chromatography
H E M †
M1
M2†
M3
M4
M5
M8
M7
MRSA whole cell
screening

71. Purified
single
compound
TLC bioautography guided
Purification of ICN16
TLC bioautography guided
Purification of ICN31
ICN19 ICN4 ICN26
*This compound is a
Β-lactamase inhibitor
Shows the anti-MRSA active spot at different Rf valuesTLC based purification
A B C
A. Visible view, B. Under UV light, C. Risazurin/TLC based bioautography

72. M1
M2†
M3
M4
M5
M8
M7
3. Purification
High Performance Liquid Chromatography
M2a, M2b, M2c………….

74. HPLC –PDA purification of anti-MRSA compound from ICN28
Analytical scale
purification
Preparative scale
purification
Active peak

75. 4. Molecular Weight determination Mass Spectroscopy
M2a ===== 401.12 da
M2b ======353.7 da
M2c ===== 838.23 da
.
.
.
.
.
.M2s =======293.2 da
Database search
And find novel ones..
Prelim results

76. ICN16
ICN31
ICN23
ICN36
ICN351
HR-LC-MS analysis
About 8 identified……. 300 Da to 600 Da

77. M2a ===== 401.12 da
M2a†
5. Structural Characerisation
Nuclear Magnetic Resonance
Spectroscopy

78. M2a ===== 401.12 da
Novel Drug
anti-infective – M2a†Yet to reach … in 2017
Started in 2008

79. Drug Discovery at ICN-MSU
Rajakamangalam
Product Development
till Dec 2015
Sample collections
Screening
Anti- Superbug assay
Solid Phase Extraction
Column Purification
TLC purification
HPLC purification
Mass Spectroscopy
NMR Spectroscopy
Live MRSA
Killed MRSA
Eight years
Of R&D
60 man power
Early stage proof of concept
79Proprietary and confidential
A recent (2014) research publication in this area by
in Indian Journal of Medical Research.
MRSA
1 neuroactive
molecule
Total 6 publications

80. BRICS Drug Discovery Networking
5 Countries
India - 25 research Groups
Microbes
Herbs
Invertebrates

85. Jan 30,2015,
‘’European Fellowships and Opportunities with funding’’ at Stella Marys College of
Engineering (near kanyakumari at the sounthern tip of India) in participation with Ms.
Ainhitze of Euraxess India. About 650 participants from 40 Institutions from southern part
of India participated. Photos from the event are given below.
www.aic.org.in
PDF of 100 Funding/Fellowships opportunities in Europe

86. To summarise
Hit/Lead
Target
Startup India
CEO …start a company ..nurture …and sell it