Practicing What We Preach: Your Role as an Obesity Medicine Specialist, Inspiring Change, and Overcoming Negative Weight Biases to Prioritize the Management of Obesity as a Chronic Disease

Obesity Management Guidelines
Full abbreviations, accreditation, and disclosure information available at PeerView.com/QFA40
Obesity
The OMA Obesity Algorithm®1
Related Resources to Check Out!
Obesity as a disease
Patient-centered communication
Data collection
Evaluation and assessment
Management plan and motivational interviewing
Nutritional
intervention
Physical
activity
Behavioral
therapy
Pharmacotherapy
Bariatric
procedures
OMA Clinical Practice Statements OMA Obesity Algorithm®
©
Obesity Medicine Association® 2023. All rights reserved.

Obesity
AACE Classification of Overweight and Obesity by BMI,
Waist Circumference, and Associated Disease Risk2
Diagnosis
BMI, kg/m2
Comorbidity
Risk
Risk of T2DM, HTN, and CVD
by Waist Circumference
Non-Asian Asian
<102 cm (men) and
<88 cm (women)b
≥102 cm (men) and
≥88 cm (women)c
Underweight <18.5 <15.5
Low but
other problems
– –
Normal weight 18.5-24.9 15.5-22.9 Average – –
Overweight 25-29.9 23-27.9 Increased Increased High
Class I obesity 30-34.9 >28 Moderate High Very high
Class II obesity 35-39.9 – Severe Very high Very high
Class III obesity ≥40 – Very severe Extremely high Extremely high

Obesity
a
Tirzepatide is not currently approved for obesity; it is currently indicated for glucose-lowering in T2DM. b
BMI ≥25 kg/m2
in Asian individuals. c
BMI ≥27.5 kg/m2
in Asian individuals. d
Use phentermine/topiramate with caution. e
Monitor all patients for depression and suicidal
thoughts, discontinue if symptoms develop. f
Liraglutide and semaglutide are associated with reduced MACE in PwT2D; tirzepatide does not increase MACE risk in PwT2D. CVOTs in PwO are ongoing.
1. Tondt J et al. Obesity Algorithm Slides, presented by the Obesity Medicine Association. www.obesityalgorithm.org. 2023. https://obesitymedicine.org/. 2. https://pro.aace.com/files/obesity/toolkit/classification_of_obesity_and_risks.pdf. 3. Chakhtoura M et al.
eClinicalMedicine. 2023;58:101882. 4. NIH. Am J Clin Nutr. 1992;55(2 Suppl):615S-619S. 5. Eisenberg D et al. Obes Surg. 2023;33:3-14. 6. Guan R et al. Front Pharmacol. 2022;13:998816. 7. https://www.accessdata.fda.gov/scripts/cder/daf/.
8. Gastaldelli A et al. Diabetologia. 2021;64(suppl 1):S219-S220.
Suggested Obesity Treatment Algorithm3-7a
BMI ≥30 or ≥27 kg/m2
with ≥1 comorbidity
BMI ≥30 kg/m2b
with T2DM
or
BMI ≥30 kg/m2b
without substantial or
durable weight loss or comorbidity
improvement using nonsurgical methods
or
BMI ≥35 kg/m2
with ≥1 adverse
health consequence because of obesity
or
BMI ≥40 kg/m2c
CVD and T2DMe
≥65
Age (years) Comorbidities
Depressiond,e
<65
History of MTCf
No
NAFLD
Yes
Obstructive
sleep apnea
Opioid use or history
of seizure
Uncontrolled HTN
Lifestyle modification
Cessation of weight-inducing medications
Bariatric
surgery
Liraglutide
Orlistat
Semaglutide
Tirzepatidea
Liraglutide
Naltrexone/bupropion
Phentermine/topiramated
Semaglutide
Tirzepatidea
All medications
Liraglutide
Orlistat
Phentermine/topiramate
Semaglutide
Tirzepatidea
Orlistat
Phentermine/
topiramate
Liraglutide
Orlistat
Semaglutide
Tirzepatide8,a
Liraglutide
Orlistat
Phentermine/topiramate
Semaglutide
Tirzepatidea
Liraglutide
Orlistat
Phentermine/
topiramate
Semaglutide
Liraglutide
Orlistat
Semaglutide
Tirzepatidea
Treatment options are listed
in alphabetical order, not by
preference of use

Guidance on Conducting a Weight Management Visit
Obesity
Weight Loss Conversation Guide
Are you concerned that your weight
may be affecting your health?
I would be happy to set up an appointment
with you to follow up when you are ready.
May I share my concerns
about your health?
Would you like help losing weight?
Reason for Losing Weight How Much Weight Loss Is Needed Suggestions for Losing It
• Reduce blood glucose and triglycerides 3% Lifestyle modification (2%-5% loss)
• Increase HDL-C
• Reduce BP, liver fat (NAFLD), and/or urinary
stress incontinence
• Improved sexual function and/or QOL
5%
Lifestyle modification (2%-5%)
Prescriptive nutritional intervention (5%-10%)
• Reduce NASH activity and/or sleep apnea 10%
Prescriptive nutritional intervention (5%-10%)
Pharmacotherapy (10%-25%)
• Reduce risk of heart attack or stroke
• Reverse T2DM
• Reduce the risk of death
15%
Pharmacotherapy (10%-25%)
Endoscopic procedures (10%-20%)
Yes Yes
No No
Yes

Obesity
Recommendations for Creating Patient-Centered Obesity Treatment Plans
Diagnose
Diagnose obesity
by class; class I
(BMI 30-34.9),
class II (BMI 35-
39.9), and class III
(BMI ≥40)
Consider stage
of disease by
severity of
comorbidities
Prescribe a
nutritional plan
• Track food
intake (eg,
LoseIt,
MyFitnessPal)
• Meal
replacement
plan like
LookAHEAD
or VLCD
• Prescriptive
nutritional
intervention
• Planned
portions of
plants and
protein
Determine an
activity goal
A minimum of 150
min (2 h and 30
min) per week of
moderate intensity
aerobic physical
activity or 75 min
(1 h and 15 min) of
vigorous intensity
physical activity is
recommended1,2
Prescribe
medication if BMI
≥27 with major
medical condition
or ≥30 alone
Talk to patient
about using
medication to
be 2-4 times
more likely to
lose weight
successfully and
maintain loss
Prescribe surgery
when indicated
Evaluate surgery
anatomy if
past history of
surgery—upper
GI and/or EGD
as indicated
Arrange follow up
1-3 mo—the more
accountability
the better
Consider remote
monitoring or
chronic care
management
for more
accountability
Prescribe Determine Evaluate
Prescribe Arrange Consider

Obesity
1. https://www.cdc.gov/physicalactivity/basics/adults/index.htm. 2. https://obesitymedicine.org/physical-fitness-and-physical-activity/.
Communication Tools: Resources for Talking With Patients About Obesity
OMA: Motivational
Interviewing Guide
NIDDK: Weight
Management
Resources for Health
Professionals
Obesity Action
Coalition: Avoiding
Stigmatizing
Language
NIDDK: Talking
With Patients About
Weight Loss
AACE: Nutrition and
Obesity Toolkit
NIDDK: Staying
Active at Any Size
AACE: Keys
to Successful
Conversations
STOP Obesity
Alliance: Guide for
the Management of
Obesity in the Primary
Care Setting
AACE: Healthy Eating
and Physical Activity
Goal Setting
Obesity Canada:
5As of Obesity
Management

Obesity
Printable Resources: Patient Intake Forms
Full abbreviations, accreditation, and disclosure information available at
PeerView.com/QFA40
To help you provide patient-centered, comprehensive obesity management in your clinic,
we’ve compiled patient intake forms you can print and use when meeting with new patients
to discuss obesity and support them through their weight loss journey.
For more information on obesity management and additional resources, visit:
https://obesitymedicine.org/
PATIENT INFORMATION FORM
Patient Name: (Last) (First) (MI)
Name you prefer to be called:
Address:
City: State: Zip:
Home Phone: Cell Phone:
Birthdate: Age:
Email Address: Social Security Number:
Sex: Male Female Transgender (F to M) Transgender (M to F) Gender queer
Choose not to disclose Other gender category not listed
Marital Status: Single Married Domestic Partnership Divorced Separated Widowed
Employment Status: Full-time Part-time Unemployed Disabled Retired Military
Employment Information
Employer: Occupation:
Employer Address:
City: State: Zip:
Work Phone: Ext:
Emergency Contact
Name: Relationship: Phone:
Primary Care Provider: Phone:
Pharmacy and Labs
Preferred Pharmacy:
Address: Phone:
Preferred Lab:
Address: Phone:
Insurance
Primary Insurance:
Secondary Insurance:
Please present your insurance card to staff at the front desk.
NEW PATIENT MEDICAL HISTORY FORM
Name: (First)______________________________ (Last) ______________________________ (MI)____
Date of Birth: _____/_____/__________ Date of Visit: _____/_____/__________
Phone: (Home/Cell)_______________________ (Work) _______________________ Gender: M / F
Referred By: ______________________________
How does your weight affect your life and health? _________________________________________
___________________________________________________________________________________
___________________________________________________________________________________
Weight History
When did you first notice that you were gaining weight?
o Childhood o Teens o Adulthood o Pregnancy o Menopause
Did you ever gain more than 20 pounds in less than 3 months? Y / N If so, when? _________
How much did you weigh: One year ago? _____ Five years ago? _____ 10 years ago? _____
At aged 18 years? _____
Life events associated with weight gain (check all that apply):
o Marriage o Divorce o Pregnancy o Abuse o Illness
o Travel o Injury o Nightshift work o Job change o Quitting smoking
o Alcohol o Drugs
o Medication (please list: ______________________________________________________________)
Previous weight-loss programs (check all that apply):
o Weight Watchers o Nutrisystem o Jenny Craig o Intermittent fasting o Atkins
o South Beach o Zone diet o Medifast o Dash diet o Paleo diet
o HCG diet o Mediterranean diet o Ketogenic diet o Other: ______________________
What was your maximum weight loss? ____________________________________________________
What are your greatest challenges with dieting? _____________________________________________
Have you ever taken medication to lose weight? (check all that apply):
o Phentermine (Adipex) o Fenfluramine/phentermine (Fen-Phen) o Fenfluramine (Pondimin)
o Lorcaserin (Belviq) o Sibutramine (Meridian) o Orlistat (Xenical/Alli)
o Semaglutide (Wegovy) o Phendimetrazine (Bontril)
o Topiramate (Topamax) o Liraglutide (Saxenda) o Diethylpropion (Tenuate)
o Hydrogel (Plenity) o Bupropion (Wellbutrin)
o Phentermine/topiramate (Qsymia) o Bupropion/naltrexone (Contrave)
o Tirzepatide (Mounjaro)
Other (including supplements): __________________________________________________________
What worked? _______________________________________________________________________
How much weight did you lose with each medication? ________________________________________
What didn’t work? ____________________________________________________________________
Why or why not? _____________________________________________________________________

PATIENT INFORMATION FORM
Patient Name: (Last) (First) (MI)
Name you prefer to be called:
Address:
City: State: Zip:
Home Phone: Cell Phone:
Birthdate: Age:
Email Address: Social Security Number:
Sex: Male Female Transgender (F to M) Transgender (M to F) Gender queer
Choose not to disclose Other gender category not listed
Marital Status: Single Married Domestic Partnership Divorced Separated Widowed
Employment Status: Full-time Part-time Unemployed Disabled Retired Military
Employment Information
Employer: Occupation:
Employer Address:
City: State: Zip:
Work Phone: Ext:
Emergency Contact
Name: Relationship: Phone:
Primary Care Provider: Phone:
Pharmacy and Labs
Preferred Pharmacy:
Address: Phone:
Preferred Lab:
Address: Phone:
Insurance
Primary Insurance:
Secondary Insurance:
Please present your insurance card to staff at the front desk.

Financial Policy
Thank you for selecting [YOUR CLINIC NAME] for your healthcare needs. We are honored to be
of service to you and your family. This is to inform you of our billing requirements and our financial
policy.
[FOR CASH-ONLY PRACTICES] Please be advised that payment for all services will be due at
the time services are rendered, unless prior arrangements have been made. For your conven-
ience, we accept [PAYMENTS YOU ACCEPT (E.G., VISA, MASTERCARD, CHECKS, ETC.)].
[FOR PRACTICES ACCEPTING INSURANCE] Please be advised that payment for all services
will be due at the time of services rendered, unless prior arrangements have been made. We
accept some forms of insurance. Please discuss your insurance coverage with a staff member.
I agree that should this account be referred to an agency or an attorney for collection, I will be
responsible for all collection costs, attorney’s fees, and court costs.
I have read and understand all of the above and have agreed to these statements.
Signature Date
Printed Name

NEW PATIENT MEDICAL HISTORY FORM
Name: (First)______________________________ (Last) ______________________________ (MI)____
Date of Birth: _____/_____/__________ Date of Visit: _____/_____/__________
Phone: (Home/Cell)_______________________ (Work) _______________________ Gender: M / F
Referred By: ______________________________
How does your weight affect your life and health? _________________________________________
___________________________________________________________________________________
___________________________________________________________________________________
Weight History
When did you first notice that you were gaining weight?
o Childhood o Teens o Adulthood o Pregnancy o Menopause
Did you ever gain more than 20 pounds in less than 3 months? Y / N If so, when? _________
How much did you weigh: One year ago? _____ Five years ago? _____ 10 years ago? _____
At aged 18 years? _____
Life events associated with weight gain (check all that apply):
o Marriage o Divorce o Pregnancy o Abuse o Illness
o Travel o Injury o Nightshift work o Job change o Quitting smoking
o Alcohol o Drugs
o Medication (please list: ______________________________________________________________)
Previous weight-loss programs (check all that apply):
o Weight Watchers o Nutrisystem o Jenny Craig o Intermittent fasting o Atkins
o South Beach o Zone diet o Medifast o Dash diet o Paleo diet
o HCG diet o Mediterranean diet o Ketogenic diet o Other: ______________________
What was your maximum weight loss? ____________________________________________________
What are your greatest challenges with dieting? _____________________________________________
Have you ever taken medication to lose weight? (check all that apply):
o Phentermine (Adipex) o Fenfluramine/phentermine (Fen-Phen) o Fenfluramine (Pondimin)
o Lorcaserin (Belviq) o Sibutramine (Meridian) o Orlistat (Xenical/Alli)
o Semaglutide (Wegovy) o Phendimetrazine (Bontril)
o Topiramate (Topamax) o Liraglutide (Saxenda) o Diethylpropion (Tenuate)
o Hydrogel (Plenity) o Bupropion (Wellbutrin)
o Phentermine/topiramate (Qsymia) o Bupropion/naltrexone (Contrave)
o Tirzepatide (Mounjaro)
Other (including supplements): __________________________________________________________
What worked? _______________________________________________________________________
How much weight did you lose with each medication? ________________________________________
What didn’t work? ____________________________________________________________________
Why or why not? _____________________________________________________________________

Nutritional History
How often do you eat breakfast? _____ days per week at _____:_____ a.m.
Number of times you eat per day: _____ What beverages do you drink? __________________________
Do you get up at night to eat? Y / N If so, how often? _____ times
List any food intolerances/restrictions: _____________________________________________________
How much water do you drink each day? ________ oz/day
Food triggers (check all that apply):
o Stress o Boredom o Anger o Insomnia o Seeking reward
o Parties o Eating out o Other: _______________________
Food cravings:
o Sugar o Chocolate o Starches o Salty o Fast food
o High fat o Large portions
Favorite foods: _______________________________________________________________________
Medical History
Exercise type: ________________________________________________________________________
Duration: _____ hours _____ minutes Number of times per week: _____
Does anything limit you from exercising? ___________________________________________________
How many hours do you sleep per night? _____ Do you feel rested in the morning? Yes / No
Do you snore? Yes / No Do you wear a CPAP? Yes / No
Past medical history (check all that apply):
o Heart attack o Angina o Gallbladder stones o Sleep apnea
o High blood pressure o Stroke o Indigestion/reflux o Thyroid
o High cholesterol o Diabetes o Celiac disease o Anxiety
o High triglycerides o Gout o Pancreatitis o Depression
o Infertility o Arthritis o Polycystic ovarian syndrome o Bipolar
o Glaucoma o Cancer (type/s): ____________________________________________
Have you ever been diagnosed with an eating disorder? Y / N If yes, which one? _________________
Past bariatric surgical history (check all that apply):
o Endoscopic balloon o Endoscopic sleeve o Gastric banding (LAGB)
o Gastric bypass (RYGB) o Sleeve gastrectomy o Biliopancreatic diversion
o Multiple bariatric surgeries o Other: _____________________________________________
Surgeon’s name: ___________________________ Place of surgery: ___________________________
Date of surgery: ___________________ Weight at time of surgery: _____________________
Lowest weight after surgery: ________________ Time to lowest weight after surgery: _______________
Complications after surgery: _________________________________________________________
Other surgical history (check all that apply):
o Gallbladder o Intestinal o Heart bypass
o Hysterectomy o Other: _________________________________________________________

Medications (list all current medications, including over-the-counter medications, supplements, and herbs):
____________________ ____________________ ____________________ ____________________
____________________ ____________________ ____________________ ____________________
Allergies:
(Medications)________________________________________________________________________
(Food)______________________________________________________________________________
Social History
Smoking: o Never o Current smoker (_____ packs/day) o Past smoker (quit _____ years ago)
Alcohol: o Never o Occasional o Regularly (_____ drinks per day)
Prior treatment for alcoholism? Y / N
Drugs: o Never o Current o Past o Type of drugs: ______________________
Marijuana: o Never o Current user (_____ times/day)
Family History
Obesity (check all that apply): o Mother o Father o Sister o Brother
o Daughter o Son
Diabetes (check all that apply): o Mother o Father o Sister o Brother
o Daughter o Son
Other (check all that apply): o High blood pressure o Heart disease o High cholesterol
o High triglycerides o Stroke o Thyroid problems o Anxiety o Depression
o Bipolar disorder o Alcoholism o Cancer (type/s): _______________________________________
Other: _______________________
Gynecologic History
Age periods started? _____ Age periods ended _____
Periods are: Regular / Irregular Heavy / Normal / Light
Contraception use: Yes or No; if yes, which medication: _______
Planning to become pregnant: Yes or No; if yes, when: ________
Number of pregnancies: _____ Number of children: _____
Age of first pregnancy: _____ Age of last pregnancy: _____
System Review
(Check all that apply)
o Recent weight loss more than 10 pounds o Recent weight gain more than 10 pounds
o Acne o Vision changes o Skin rash
o Cough o Chest pain o Difficulty breathing
o Snoring o Difficulty breathing when flat o Fainting/blacking out
o Palpitations o Swelling ankles/extremities o Abdominal pain
o Bloating o Constipation o Diarrhea
o Food intolerance o Indigestion o Nausea/vomiting
o Dysphagia/difficulty swallowing o Increased appetite o Decreased appetite
o Heartburn o Gas and bloating o Urinary frequency/urgency
o Slow urine flow o Nighttime urination o Blood in stools

o Back pain (upper) o Back pain (lower) o Joint pain
o Muscle aches/pain o Dizziness o Headaches
o Seizures o Weakness/low energy o Anxiety
o Depression o Insomnia o Memory loss
o Inability to concentrate o Mood changes o Nervousness
o Loss of interest o Cold intolerance o Excessive sweating
o Hair changes o Heat intolerance o Blood clots
o Fatigue/tiredness o Loss of interest in sex
(Women only)
o Absence of periods o Hot flashes o Change in bladder habits
o Abnormal/excessive menstruation o Facial hair o Difficulty getting pregnant
o Easy bruising o Sensitive fat tissue
(Men only)
o Difficulty in getting erections o Low testosterone
Comments: _________________________________________________________________________
___________________________________________________________________________________
___________________________________________________________________________________

Obesity Treatment Strategies: A Quick Reference Guide
Obesity
3x/day
Lipid
excretion
(GI
tract)
Appetite
regulation
(CNS)
Liraglutide
3 mg 1x/day
How
What When
Orlistat
Phenterminea
/
topiramate ER 1x/day
Naltrexone ER/
bupropion ER 2x/day
Naltrexone ER/Bupropion ER
Week 1 One tab (8/90 mg) by mouth each morning
Week 2 One tab (8/90 mg) by mouth twice daily
Week 3
Two tabs (16/180 mg) by mouth each morning
and one tab (8/90 mg) by mouth at bedtime
Week 4 Two tabs (16/180 mg) by mouth twice daily
Liraglutide 3 mg
Start at 0.6 mg subQ once daily for 1 week;
in weekly intervals, increase the dose until a dose of 3 mg is reached
Semaglutide 2.4 mg
Start at 0.25 mg subQ once weekly for 4 weeks;
in 4-week intervals, increase the dose until a dose of 2.4 mg is reached
Semaglutide
2.4 mg 1x/week
Hydrogel
4.5 g 2x/day
Hydrogel
Three 0.75-g capsules by mouth at lunch
and three 0.75-g capsules by mouth at dinner daily
Phentermine/Topiramate ER
Starting 3.75/23 mg by mouth once daily (2 weeks)
Recommended 7.5/46 mg by mouth once daily
Escalation 11.25/69 mg by mouth once daily
Maximum 15/92 mg by mouth once daily
Orlistat
120 mg by mouth three times daily before meals
60 mg by mouth for OTC formulation
Dosing and Administration1-3
Titration Schedules1-3
Approved Anti-Obesity Medications for Long-Term Use
a
Phentermine alone is approved only for short-term use.

Obesity
Weight-loss agents should not be used in individuals who are pregnant and should not be used during breastfeeding;
for additional information on contraindications, warnings, precautions, and adverse effects, please consult the prescribing information for each drug
Contraindications, Precautions, and Common Adverse Effects1-3
Drug Contraindications and Precautions Common Adverse Effects
• Chronic malabsorption syndrome
• Cholestasis
• Pregnancy
Orlistat
• Decreased absorption of fat-soluble vitamins
• Steatorrhea
• Oily spotting, fecal urgency, and oily evacuation
• Increased defecation
• Uncontrolled HTN
• Seizure disorders
• Anorexia nervosa or bulimia
• Benzodiazepines, anti-epileptics, barbiturates, and alcohol withdrawal
• MAOI, opioids, bupropion
• Pregnancy
Naltrexone ER/
bupropion ER
• Nausea
• Constipation
• Headache
• Vomiting
• Dizziness
• History of MTC or MEN2
• Pregnancy
• Nausea
• Vomiting
• Diarrhea
Liraglutide 3 mg
• Constipation
• Fatigue
• Headache
• Pregnancy
• Diarrhea
• Flatulence
• Constipation
Hydrogel 4.5 g
• Pain/abdominal swelling
• Infrequent bowel movements
• Nausea
• History of MTC or MEN2
• Pregnancy
• Nausea
• Vomiting
• Diarrhea
• Constipation
• Fatigue
• Headache
Semaglutide 2.4 mg
• Pregnancy
• Hyperthyroidism
• Glaucoma
• MAOI
• Sympathomimetic amines
Phentermine/
topiramate ER
• Insomnia
• Dry mouth
• Constipation
• Paresthesia
• Dizziness
• Dysgeusia

Obesity
a
Very low–carbohydrate, ketogenic diet for individuals with T2DM. b
Tirzepatide is not currently approved for obesity; it is currently indicated for glucose-lowering in T2DM. c
Hydrogel is a medical device.
1. Garvey WT et al. Endocr Pract. 2016;22(suppl 3):1-203. 2. Apovian CM et al. J Clin Endocrinol Metab. 2015;100:342-362. 3. https://www.accessdata.fda.gov/scripts/cder/daf/. 4. Wilding JPH et al. N Engl J Med. 2021;384:989-1002. 5. Jebb SA et al. Lancet. 2011;378:1485-1492.
6. Maciejewski ML et al. JAMA Surg. 2016;151:1046-1055. 7. Wadden TA et al. Obesity (Silver Spring). 2011;19:110-120. 8. Wadden TA et al. Obesity (Silver Spring). 2019;27:75-86. 9. Athinarayanan SJ et al. Front Endocrinol. 2019;10:348. 10. Jastreboff AM et al. N Engl J Med. 2022;387:205-216.
Weight Loss
Goal, %
Behavioral
Programs
Proprietary
Ketogenic
Dietary
Program
Phen/Top
15/92 mg
Bup/Nal
(Plus IBT)
Liraglutide
3 mg Daily
(Plus IBT)
Semaglutide
2.4 mg
Weekly
Tirzepatide
15 mg
Weeklyb
Hydrogelc
Surgery
at 10
Years, %
>5 48% 74% 67%
42%
(66%)
63%
(74%)
90% 96% 59% 97%
>10 25% 49% 47%
21%
(41%)
33%
(52%)
75% 90% 27% >80%
>15 12% – 32%
10%
(29%)
–
(36%)
56% 78% – –
>20 10% – 15% – – 36% 63% – 72%
>30 4% – – – – – 23% – 40%
Side-By-Side Comparison of Current and Emerging Treatments:
Proportion of Patients Attaining Weight Loss Goal4-10

Know More About Anti-Obesity Medications
Obesity
Patient-centered education and support is key in obesity management.
Please use the printable resource on the following pages to support
conversations about long-term anti-obesity medications with your patients. Your
patients should have access to this resource at home so they can learn more about
the role of anti-obesity medication in treating this chronic disease, how effective
each medication may be, and which adverse reactions are commonly associated
with these medications.

a
Tirzepatide is not currently approved for obesity; it is currently indicated for glucose-lowering in T2DM.
1. Tak YJ, Lee SY. Curr Obes Rep. 2021;10:14-30. 2. Bays HE et al. Obesity Pillars. 2022;4:100039. 3. Matza LS et al. Patient. 2022;15:367-377. 4. Maski K et al. J Clin Sleep Med. 2021;17:1895-1945. 5. Christensen SM et al. Obesity Pillars. 2022;4:100041.
6. Redmond IP et al. Curr Obes Rep. 2021;10:81-99. 7. Jastreboff AM et al. N Engl J Med. 2022;387:205-216.
Effectively Managing Your Obesity: Aligning Treatment With the Right Medication1-7
Ways in Which Treatment Can Help Recommended Medications to Consider
Nutrition
• Prevents fat absorption from food1
• Orlistat
• Slows down digestion1
• Liraglutide and semaglutide
Physical activity • Increases one’s desire to be active with weight loss2,3
• Tirzepatidea
Behavior
• Reduces appetite1,3 • Phentermine/topiramate, naltrexone/bupropion, liraglutide,
semaglutide, and tirzepatidea
• Reduces cravings and/or binge eating1,3 • Naltrexone/bupropion, phentermine/topiramate, liraglutide,
semaglutide, and tirzepatidea
• Increases sense of fullness1
• Liraglutide, semaglutide, and hydrogel
• Improves sleep3,4
• Liraglutide and tirzepatidea
Medication
• May prevent weight gain caused by other medications, including
but not limited to medications for depression, schizophrenia,
bipolar disorder, and insulin5
• See the next page for more information
Bariatric
procedures
• Prevent weight regain after bariatric surgery6
• Partly reverse weight gain after surgery6
• Liraglutide, semaglutide, tirzepatide,a
orlistat,
and phentermine/topiramate
Pairing weight loss medication with behavioral changes like learning to eat more slowly, noticing when you feel full,
and becoming more active has a greater effect on improving your health, as research has shown (see next page).

a
Greater weight loss is likely if combined with intensive behavioral therapy. b
Tirzepatide is not currently approved for obesity; it is currently indicated for glucose-lowering in T2DM.
1. Wilding JPH et al. N Engl J Med. 2021;384:989-1002. 2. Jebb SA et al. Lancet. 2011;378:1485-1492. 3. Maciejewski ML et al. JAMA Surg. 2016;151:1046-1055. 4. Wadden TA et al. Obesity (Silver Spring). 2011;19:110-120. 5. Wadden TA et al. Obesity (Silver Spring). 2019;27:75-86.
6. Athinarayanan SJ et al. Front Endocrinol. 2019;10:348. 7. Jastreboff AM et al. N Engl J Med. 2022;387:205-216. 8. https://www.accessdata.fda.gov/scripts/cder/daf/. 9. https://www.myplenity.com/siteassets/components/pdfs/acq_hcp_plenity-physician-ifu_march_2021.pdf.
10. Greenway FL et al. Obesity (Sliver Spring). 2019;27:205-216.
What to Expect When Taking an Anti-Obesity Medication1-10
With Each Medication, How Likely Am I to Lose
the Following Percentage of Weight?a
What Effects Might I Experience
When I Start Taking This Medication?
5% 10% 15% 20%
Orlistat
Taken orally,
3x/day
+++ + – –
• Oily spotting on underwear/clothing
• Fatty/oily stool
• Intestinal gas with discharge
• Sudden urge to have a bowel movement
• Increased number of bowel movements
• Difficulty controlling bowel movements
• Rectal leakage
Phentermine/
topiramate ER
Taken orally, 1x/day
++++ +++ ++ +
• Tingling or prickling sensations
• Dizziness
• Change in sense of taste
• Insomnia
• Constipation
• Dry mouth
Naltrexone ER/
bupropion ER
Taken orally,
2x/day
+++ ++ + –
• Nausea
• Constipation
• Headache
• Vomiting
• Dizziness
• Insomnia
• Dry mouth
• Diarrhea
Liraglutide
3.0 mg
Once daily
injection
+++ ++ – –
• Nausea
• Diarrhea
• Constipation
• Vomiting
• Soreness at injection site
• Fever
• Headache
• Low blood sugar
• High levels of lipase
• Upper abdominal pain
• Stomach flu
Semaglutide
2.4 mg
Once weekly
injection
+++++ ++++ +++ ++
• Nausea
• Diarrhea
• Constipation
• Pain in stomach/abdomen
• Low blood sugar
• Stomach flu
• Headache
• Fatigue
• Dizziness
• Bloating/swelling in belly
• Belching
• Flatulence
• Gastroesophageal reflux disease
Tirzepatideb
Once weekly
injection
+++++ +++++ ++++ ++++
• Nausea
• Diarrhea
• Decreased appetite
• Vomiting
• Constipation
• Pain/discomfort in the stomach/abdomen
Hydrogel
Taken orally,
2x/day
++++ ++ – –
• Diarrhea
• Pain/swelling in belly
• Infrequent bowel movements
• Flatulence
• Constipation
• Nausea
+ = 0%-19% ++ = 20%-39% +++ = 40%-59% ++++ = 60%-79% +++++ = 80%-100%

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