The newsletter provides information on senology apps for mobile devices, collaborations, literature on breast cancer risk factors and treatments, upcoming conferences, and workshop summaries on various cancer types. It also includes an editorial on medications to reduce breast cancer risk, recent advances in hepatitis C treatment, and a call for opinions on sentinel lymph node biopsy guidelines.

1. Senology.org - Newsletter
International Senologic and Oncologic Scientific Community (ISOSC)
"Connecting specialists worldwide"
June 4, 2013
Editor-in-Chief: Gian Paolo Andreoletti, MD
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Literature Selection
Jiang W et al.: "Coffee and caffeine intake and breast cancer risk: An updated dose-response meta-
analysis of 37 published studies", Gynecol Oncol. 2013 Jun;129(3):620-9
Poole EM et al.: "Postdiagnosis supplement use and breast cancer prognosis in the After Breast
Cancer Pooling Project", Breast Cancer Res Treat. 2013 May 10. [Epub ahead of print]
Cooke R et al.: "Breast cancer risk following Hodgkin lymphoma radiotherapy in relation to menstrual
and reproductive factors", Br J Cancer. 2013 May 7[Epub ahead of print]
Schaverien MV et al.: "Effect of neoadjuvant chemotherapy on outcomes of immediate free
autologous breast reconstruction", Eur J Surg Oncol. 2013 May;39(5):430-6
Wong AW et al.: "Prophylactic use of levonorgestrel-releasing intrauterine system in women with
breast cancer treated with tamoxifen: a randomized controlled trial", Obstet Gynecol. 2013 May;121
(5):943-50
Tran BH et al.: "Risk factors associated with venous thromboembolism in 49,028 mastectomy
patients", Breast. 2013 May 18 [Epub ahead of print]
van Hoesel AQ et al.: "Assessment of DNA methylation status in early stages of breast cancer
development", Br J Cancer. 2013 May 7 [Epub ahead of print]
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2. Editorial
"Use of medications to reduce breast cancer risk", Heidi D. Nelson, Oregon Health & Science University,
Veterans Affairs Medical Center, Portland, OR, USA
"Our review on use of medications to reduce risk for primary breast cancer indicated that tamoxifen and
raloxifene reduced the incidence of invasive breast cancer in women without cancer, but also increased risk
for blood clots. Tamoxifen was more effective than raloxifene in reducing breast cancer, but also increased
the incidence of endometrial cancer and cataracts. Both reduced fractures. Adverse effects were more
common in older compared to younger women. Wide-spread use is limited by the adverse effects of
medications and inaccurate methods to identify candidates. Medications reduce invasive breast cancer by 7
to 9 cases per 1000 women, assuming 5-years of use. There are 5 per 1000 fewer cases among women
using tamoxifen than raloxifene. Estrogen receptor positive breast cancers were reduced, but not estrogen
receptor negative"
(Commentary on: Nelson H et al.: "Use of medications to reduce risk for primary breast cancer: a
systematic review for the u.s. Preventive services task force", Ann Intern Med. 2013 Apr 16;158(8):604-
14)
Questions and Answers
Breast Cancer Workshop Summary - with Katherine Crew, New York-Presbyterian/Columbia University
Medical Center, New York, NY, USA
Discussion
"Guidelines for sentinel lymph node biopsy in contralateral prophylactic mastectomy need to be
established to avoid overtreatment" - Share your opinion on LinkedIn
Fragments of History
1981 - Umberto Veronesi, National Cancer Institute, Milan, Italy - "In conclusion, the data from our trial show
that patients with early breast cancer who are treated with quadrantectomy and axillary dissection plus
radiotherapy have the same survival rate and the same incidence of local and distant recurrences as patients
who are treated with the Halsted mastectomy. On the basis of this study, radical mastectomy appears to
involve unnecessary mutilation in patients with carcinoma of the breast measuring less than 2 cm and without
palpable axillary nodes". (Veronesi U et al.: "Comparing radical mastectomy with quadrantectomy,
axillary dissection, and radiotherapy in patients with small cancers of the breast", N Engl J
Med.1981Jul 2;305(1):6-11)
Calendar of Events
15th Milan Breast Cancer Conference, June 20-21, 2013, Milan, Italy
3rd World Congress on Cancer Science & Therapy, October 21-23, 2013, San Francisco, CA, USA - in
partnership with Senology
9th Meet the Professor. Advanced International Breast Cancer Conference (AIBCC), November 11-13,
Padova, Italy - under the Patronage of Senology
Update in Breast Imaging, 22-23 November, Ostend, Belgium
Literature Selection
Mathews JD et al.: "Cancer risk in 680 000 people exposed to computed tomography scans in
childhood or adolescence: data linkage study of 11 million Australians", BMJ. 2013 May 21;346:f2360
Mols F et al.: "Depressive symptoms are a risk factor for all-cause mortality: results from a
prospective population-based study among 3,080 cancer survivors from the PROFILES registry", J
Cancer Surviv. 2013 May 16. [Epub ahead of print]
Duo J et al.: "Comparison of FDG PET/CT and Gadolinium-Enhanced MRI for the Detection of Bone
Metastases in Patients With Cancer: A Meta-analysis", Clin Nucl Med. 2013 May;38(5):343-8
Langevin SM et al.: "Gastric Reflux Is an Independent Risk Factor for Laryngopharyngeal Carcinoma",
Cancer Epidemiol Biomarkers Prev. 2013 May 23. [Epub ahead of print]
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3. Zhang X et al.: "Associations of self-reported sleep duration and snoring with colorectal cancer risk in
men and women", Sleep. 2013 May 1;36(5):681-8
Sigurdardottir LG et al.: "Sleep disruption among older men and risk of prostate cancer", Cancer
Epidemiol Biomarkers Prev. 2013 May;22(5):872-9
Daskivich TJ et al.: "Effect of Age, Tumor Risk, and Comorbidity on Competing Risks for Survival in a
U.S. Population-Based Cohort of Men With Prostate Cancer", Ann Intern Med. 2013 May 21;158
(10):709-717
The National Lung Screening Trial Research Team : "Results of Initial Low-Dose Computed
Tomographic Screening for Lung Cancer", N Engl J Med. 2013 May 23;368(21):1980-1991
Pasquier E et al.: "β-blockers increase response to chemotherapy via direct antitumour and anti-
angiogenic mechanisms in neuroblastoma", Br J Cancer. 2013 May 21 [Epub ahead of print]
Questions and Answers
Liver Cancer Workshop Summary - with Richard Finn, UCLA Jonsson Comprehensive Cancer Center, Los
Angeles, CA, USA
Kidney Cancer Workshop Summary - with William Huang, NYU Langone Medical Center, New York, NY,
USA
Melanoma Workshop Summary - with Patrick Hwu, The University of Texas MD Anderson Cancer Center,
Houston, TX, USA
Cervical Cancer Workshop Summary - with Stewart Massad, Washington University, St. Louis, MO, USA
Lung Cancer Workshop Summary - with Glen J. Weiss, Cancer Treatment Centers of America, Goodyear,
AZ, USA
Literature Selection
Dobson SR et al.: "Immunogenicity of 2 doses of HPV vaccine in younger adolescents vs 3 doses in
young women: a randomized clinical trial", JAMA. 2013 May 1;309(17):1793-802
Yang HP et al.: "Ovarian Cancer Incidence Trends in Relation to Changing Patterns of Menopausal
Hormone Therapy Use in the United States", J Clin Oncol. 2013 May 6. [Epub ahead of print]
Stay informed....
Recent Advances in Clinical Medicine
Janssen HL et al.: "Treatment of HCV infection by targeting microRNA ", N Engl J Med. 2013 May
2;368(18):1685-94
Jacobson IM et al.: "“Sofosbuvir for hepatitis C genotype 2 or 3 in patients without treatment
options”, N Engl J Med. 2013 May 16;368(20):1867-77
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