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Genetics, Immunology and Therapeutic Targets Breakout Report

Report on key points of discussion from Genetics, Immunology and Therapeutic Targets breakout group.

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Genetics, Immunology and Therapeutic Targets Breakout Report

  1. 1. Genetics, Immunology, and Therapeutic Targets Breakout Group Report
  2. 2. What has already been done and how is it related? • Identification of new targets…but there must be more • Are we looking in the right places? Hair follicle..? ECM..? • Are we looking for the right signals…? Other cytokines…? • Are we looking at the right cells…? NK? Other regulatory cells? • Efforts toward antigen discovery progress being made and needs to keep going • What can we learn from patients who don’t respond to JAK inhibitors? • How can we better define those who will respond to JAK inhibitors?
  3. 3. What questions still need to be answered? • Need to understand how to stratify/select patients • What defines a JAK responder vs a JAK non-responder? • Are all non-responders not responding for same reason(s)? Different reason(s)? • Are there confounding diagnoses in JAK treated patients (AGA, other alopecias?) • Can we define a set of markers to select/stratify JAK responders, and group the non-responders for further studies? • What is the mechanism of longstanding disease? Is there burnout? • Correlation of clinical status with research efforts – new onset patients, longstanding disease, pediatric populations, etc.
  4. 4. What resources are needed? • Additional funding for immunological studies • Exploration to other immune mechanisms – NK cells, gammadelta T cells, Tregs, B cells, DCs, mast cells, monocytes, others • Further genetic studies – only 14 confirmed genes so far…there are likely many more. Defining complete architecture to find more pathways, potentially the ‘minor’ ones • Biology of the end organ – hair follicle, cycle, pigmentation- and its role in disease • Consideration of environmental factors that interact with genetics • Biomarkers and tools to monitor response to treatments
  5. 5. What can NAAF do to help? • Liaise with other autoimmune disease groups to leverage research findings, funding schemes, research priorities, shared disease mechanisms (T1D, RA, thyroiditis, vitiligo, etc) • Continued funding of exploratory ideas, to advance new concepts and young investigators • Continue to drive drug development pathway • Continued emphasis on developing new outcome measures • Continue with Research Summit to help define priorities and set the agenda for the coming years!

Report on key points of discussion from Genetics, Immunology and Therapeutic Targets breakout group.

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