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2010 Conference - Toward a Treatment Standard for Pathological Gambling (Grant)
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Placebo 20mg 40mg PG-YBOCS Urges 10 8 p=.027 6 4 2 4 6 8 10 Visit
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1.0
.9 .8 Naltrexone / Proportion Nonrelapsed Asp40 Allele (A/G, G/G) .7 Naltrexone .6 Asn40 Allele (A/A) .5 Placebo / Asp40 Allele (A/G, G/G) .4 Placebo / Asn40 Allele (A/Al) .3 .2 .1 0.0 0 14 28 42 56 70 84 Days
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Analysis of Maximum
Likelihood Estimates (N=282) Variable Parameter Standard Chi- Pr>ChiSq Hazard Estimate Error Square Ratio FH-AUD 0.55 0.24 7.53 0.006 1.74 Baseline urges were significantly associated with response to higher doses of opiate antagonists (i.e. nalmefene 50mg or 100mg or naltrexone 100mg or 150mg) (parameter estimate = 1.77; SE= 0.84; Wald 2 =4.41; p= .036; HR= 5.86; HR 95% CI=1.12-30.6
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N-Acetyl Cysteine: 12-Week
Open-Label 56% reduction in urges; 57% reduction in total gambling symptoms
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Visit 1 Visit
6 p-value PG-YBOCS total score 21.8 8.9 <.001 Responder, n (%) n/a 18 <.001 (62.1) Dollars lost per week 743 309 <.001 Hours gambled per week 10.4 4.0 <.001
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PG B v
E PG B v C PG E v C T P t p t p IDED total 2.20 0.037 2.09 0.041 1.06 0.294 errors
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Lexapro Treatment of
Anxious Gamblers
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*
* * * p<.05 Hollander et al, 2002
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