1. Methods of Asymmetric
Synthesis using chiral pool
PERSENTED TO :- PRESENTED BY:-
Dr.Kuldeep Singh Shafiurahman
Faculty of Pharmacy M. Pharm 1st year
Integral University

2. CONTENT
Asymmetric synthesis
Methods of asymmetric synthesis
using chiral pool
Chiral auxiliaries and catalytic
asymmetric synthesis
Enantiopure separation
Stereoselective synthesis
References

3. ASYMMETRIC SYNTHESIS
The direct synthesis of an optically active substance from optically inactive
compound with or without the use of optically active reagents is called
asymmetric synthesis.

4. LEVOCETIRIZINE
DEXTROCETIRIZINE

6. 3.enantioselective catalysts
sharless asymmetric epoxidation

12. ENANTIOPURE SEPERATION
Enantiopure seperation is a process of seprating isomers
in a racemic mixture into their individual enantiomer.
1.Selective crystalisation
2.Supercritical extraction
3.Fractional reaction extraction
4.Diastereomer separation by distillation
5.Membrane assisted seperation
6.Chromatography and simulated moving bed

13. STEREOSELECTIVE SYNTHESIS
Stereoselective reactions- reactions where one stereoisomer of
products is formed predominantly because the reaction has a
choice of pathways,and one pathway is more favourable than
the other.

14. The fact that the addition of halogens to alkenes is both
stereoselective and stereospecific give us additional
information about the stereochemistry of the addition and
the mechanism for the reaction.

15. REFERENCES
Wikipedia
Slide share

16. THANK
YOU