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Viral Hepatitis
Hepatitis B & C focus
In the world, sex has infected 34 million people with HIV, how
many people has blood infected with viral hepatitis?
2 million 20 million
200 million 2000 million
Blood & Blood spill has infected 2,000 million people and >360 million have long-
term liver infection. “three” people die every minute due to viral hepatitis.
(http://www.who.int/immunization/topics/hepatitis/en/) & http://www.who.int/hepatitis/en/
What % of people living with hepatitis KNOW they are infected?
Less than 5%
30%
50%
>90%
WHO, 2013
Hepatitis caused by different types of viruses
A & E B ±D& C
Sources
Transmission route
Chronic liver disease No Yes
A, B, C, D & E
Today, a total number of people living with chronic
hepatitis (B & C) is:
350,000
3,500,000
35,000,000
350,000,000
1 in 20 people infected with HBV & HCV
amongst 7.4 billion population
WHO, 2013
1 in 10 Myanmar 15-80 Yrs has hepatitis
HBV 6 in 10
HCV 3 in 10
B & C 1 in 10
Department of Medical Research, the Department of Public Health and the Myanmar Liver Foundation
Survey in 18 townships across nine states and regions between May – Nov, 2015
The Highest %
The Lowest %
HBV HCV
Yangon
12.4%
Magway
3.3%
Mon
10.3%
Bago/Chin
0.3%
Hepatitis B & C prevalence by Region
Department of Medical Research, the Department of Public Health and the Myanmar Liver Foundation
Survey in 18 townships across nine states and regions between May – Nov, 2015
Hepatitis B and C?
Chronic inflammation & Fibrosis
Cirrhosis
Cancer
How Hepatitis B & C spread?
Infection source Definitely Rarely
Exposure to blood
Needle stick injury
IV drug used (shared needle)
Orally
Sexually
Mother to child at birth
tattooing
B C
B C
B C
B C
B C
B
B
C
C
http://www.hivandhepatitis.com/hep_c/vaccines.html
HBV & HCV do not spread through:
Hepatitis B & C virus is not spread by sharing eating utensils, breastfeeding, hugging,
kissing, holding hands, coughing, or sneezing. It is also not spread through food or water.
http://www.cdc.gov/hepatitis/hcv/cfaq.htm
What happen after exposure to Hepatitis B?
ESLD
Cirrhosis
HCC
Chronic
hepatitis B
1. EASL. J Hepatol. 2012;57:167-185 & http://www.meds.com/hepatitis/casebased/dienstag.html
>5% 30%
10%
20%
124 32Weeks 24
HBe
52
Anti-HBe if recover
HBs Ag
Anti-HBsHBV
exposed
Hbe Ag
What happen after exposure to Hepatitis C?
Inflamed liver Cirrhosis of liver Carcinoma of liver
75-85%
Chronic hepatitis
5 - 20%
Cirrhosis
1 - 5%
Carcinoma
20 years 10 years
http://www.cdc.gov/hepatitis/hcv/cfaq.htm
How do we know whether we have HBV or HCV infection?
If my hepatitis B/C is positive, what should I do?
Acute infection
Chronic Cirrhosis Carcinoma
HBV/HCV serology testing
HBV/HCV viral load
Liver function test
USG (liver)
CT scan
Is Hepatitis B infection curable?
Not curable but timely treatment of HBV infected Hepatitis:
Slow down of progress of liver disease
Reversal with HBV suppression
Is Hepatitis C infection curable?
Over 90% of people with Hepatitis C can be completely cured within 3-6 months.
http://www.who.int/campaigns/hepatitis-day/2016/en/
Is there a vaccine that can prevent Hepatitis B or C?
But No Vaccine for Hepatitis C

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Basic info about Hepatitis B & C

  • 2. In the world, sex has infected 34 million people with HIV, how many people has blood infected with viral hepatitis? 2 million 20 million 200 million 2000 million Blood & Blood spill has infected 2,000 million people and >360 million have long- term liver infection. “three” people die every minute due to viral hepatitis. (http://www.who.int/immunization/topics/hepatitis/en/) & http://www.who.int/hepatitis/en/
  • 3. What % of people living with hepatitis KNOW they are infected? Less than 5% 30% 50% >90% WHO, 2013
  • 4. Hepatitis caused by different types of viruses A & E B ±D& C Sources Transmission route Chronic liver disease No Yes A, B, C, D & E
  • 5. Today, a total number of people living with chronic hepatitis (B & C) is: 350,000 3,500,000 35,000,000 350,000,000 1 in 20 people infected with HBV & HCV amongst 7.4 billion population WHO, 2013
  • 6. 1 in 10 Myanmar 15-80 Yrs has hepatitis HBV 6 in 10 HCV 3 in 10 B & C 1 in 10 Department of Medical Research, the Department of Public Health and the Myanmar Liver Foundation Survey in 18 townships across nine states and regions between May – Nov, 2015
  • 7. The Highest % The Lowest % HBV HCV Yangon 12.4% Magway 3.3% Mon 10.3% Bago/Chin 0.3% Hepatitis B & C prevalence by Region Department of Medical Research, the Department of Public Health and the Myanmar Liver Foundation Survey in 18 townships across nine states and regions between May – Nov, 2015
  • 8. Hepatitis B and C? Chronic inflammation & Fibrosis Cirrhosis Cancer
  • 9. How Hepatitis B & C spread? Infection source Definitely Rarely Exposure to blood Needle stick injury IV drug used (shared needle) Orally Sexually Mother to child at birth tattooing B C B C B C B C B C B B C C http://www.hivandhepatitis.com/hep_c/vaccines.html
  • 10. HBV & HCV do not spread through: Hepatitis B & C virus is not spread by sharing eating utensils, breastfeeding, hugging, kissing, holding hands, coughing, or sneezing. It is also not spread through food or water. http://www.cdc.gov/hepatitis/hcv/cfaq.htm
  • 11. What happen after exposure to Hepatitis B? ESLD Cirrhosis HCC Chronic hepatitis B 1. EASL. J Hepatol. 2012;57:167-185 & http://www.meds.com/hepatitis/casebased/dienstag.html >5% 30% 10% 20% 124 32Weeks 24 HBe 52 Anti-HBe if recover HBs Ag Anti-HBsHBV exposed Hbe Ag
  • 12. What happen after exposure to Hepatitis C? Inflamed liver Cirrhosis of liver Carcinoma of liver 75-85% Chronic hepatitis 5 - 20% Cirrhosis 1 - 5% Carcinoma 20 years 10 years http://www.cdc.gov/hepatitis/hcv/cfaq.htm
  • 13. How do we know whether we have HBV or HCV infection?
  • 14. If my hepatitis B/C is positive, what should I do? Acute infection Chronic Cirrhosis Carcinoma HBV/HCV serology testing HBV/HCV viral load Liver function test USG (liver) CT scan
  • 15. Is Hepatitis B infection curable? Not curable but timely treatment of HBV infected Hepatitis: Slow down of progress of liver disease Reversal with HBV suppression
  • 16. Is Hepatitis C infection curable? Over 90% of people with Hepatitis C can be completely cured within 3-6 months. http://www.who.int/campaigns/hepatitis-day/2016/en/
  • 17. Is there a vaccine that can prevent Hepatitis B or C? But No Vaccine for Hepatitis C