1. REQUEST # 67644
Anti-Adherence to Skin and Hard Surfaces
RESPONSE DUE DATE: December 9, 2011
MANAGER: Jack Lienesch
SOLUTION PROVIDER HELP DESK
EMAIL: PhD@ninesigma.com PHONE: +1-216-283-3901
Opportunity
Licensing, product acquisition, contract research, proof of
(click buttons above)
concept leading to scale-up to manufacturing, joint development,
supplier agreement, etc.
Timeline
Phase 1 – 12 months for proof of concept in a laboratory
Phase 2 – Commercial development to be determined
Financials
Phase 1 – Laboratory proof of concept funding up to
US$ 100,000
Phase 2 – To be negotiated
REQUEST FOR PROPOSAL DESCRIPTION  Novel surface treatments that repel
proteins, bacteria, and dirt/grime
NineSigma, representing a Fortune 500  Durable anti-adherent treatments that can
consumer products company, seeks proposals resist abrasion
for the development of technologies that prevent
the adhesion of biological materials onto surfaces Technology solutions that are of short-term
(either hard surfaces or skin, ideally both). Of duration (i.e., would last a few hours up to eight
particular interest are partners with technology hours and possibly up to a day) would be ideal.
solutions that are ready to commercialize or
could be readied for commercialization within 1-2 BACKGROUND
years.
Current cleaning approaches are designed to
Examples of novel approaches of interest would remove contamination (dirt, bacteria, stains) once
include: they have attached onto a surface. There are
 Anti-adherence formulations for hands, few examples of any treatments or materials that
skin, and mucus tissues are designed to keep a surface clean after they
 Anti-adherent formulations for hard have been applied, such that the surface
surfaces including metal, plastic and becomes resistant to future adherence and
natural materials contamination. Typical approaches to this are to
 Anti-adherent compositions that can be change the surface hydrophobicity such that the
easily applied to skin or hard surfaces water contact angle is substantially increased
using either wipe or spray techniques (making the surface water-repellent). While this
 Compositions must have acceptable type of surface treatment is readily applied to
aesthetic and safety profiles hard non-porous surfaces, it cannot be extended
to skin.
Offices: Cleveland - USA, Tokyo - Japan, Leuven - Belgium www.ninesigma.com
RFP format and graphics© Copyright 2011 NineSigma, Inc

2. NineSigma Request #67644 Anti-Adherence to Skin and Hard Surfaces Page 2
Similar treatments for skin are virtually non-
existent. Our client sees this as a unique
opportunity to develop a skin-friendly technology APPROACHES NOT OF INTEREST
that would provide a barrier to adherence of
bacteria, proteinacious materials, as well as dirt
and grime. Such skin products would have broad  Technologies that are based on biocidal or
applicability in both the consumer and healthcare biostatic action.
markets.  Incremental variations on fluorocarbon
surface treatments
POSSIBLE APPROACHES  Technology solutions without patent
protection (IP must already be issued or
Examples of applications of interest for
filed)
NineSigma’s client would include the following
(note, your technology does not necessarily need
to address one of these specific examples): ANTICIPATED PROJECT PHASES OR PROJECT PLAN
 It is expected that the compositions or
Phase 1 – Proof of concept in our client’s
formulations will provide for the reduction of
laboratory
attachment of bacteria, fungi, and viruses
Phase 2 – Commercial development to be
by at least 99% for a period of up to 8
determined
hours.
 It is expected that the compositions or CRITERIA FOR MOVING FROM PHASE 1 TO PHASE 2
formulations will provide for the reduction of
attachment of organic soil by at least 99%
for a period of up to 8 hours. Demonstrate in our client’s laboratory that the
 Hydrophilic materials that are dermal anti- proposed approach meets all the requirements
adherents.
 Hydrophobic and hydrophilic combinations APPROPRIATE RESPONSES TO THIS REQUEST
that are hard surface anti-adherents
 Competitive displacement compositions for Responses from companies (small to large),
both microbes and organic soil academic researchers, other research institutes,
 Compositions that are naturally-derived consultants, venture capitalists, entrepreneurs, or
 Compositions that can be used over a wide inventors are welcome.
range of surfaces both animate and
inanimate. I am a company or academic person with
 Compositions that reduce inorganic technology which should provide a solution ready
depositions to hard surfaces for testing and transfer to commercial use.
 Compositions that reduce adherence of
biological fluids, blood, sputum, urine, I am a company or academic person with
feces, complex polysaccharides to skin and technology which should provide a solution but
mucosal tissue. that requires further research and development
to ready it for transfer to commercial use.
 Compositions that reduce attachment of
infectious microbes, filamentous fungi,
yeast, fungal spores, bacterial spores,
Gram negative bacteria, Gram positive
bacteria, enveloped viruses, non-enveloped
viruses to skin and mucosal tissue.
 Compositions that use Quorum sensing
control
Offices: Cleveland - USA, Tokyo - Japan, Leuven - Belgium www.ninesigma.com

3. NineSigma Request #67644 Anti-Adherence to Skin and Hard Surfaces Page 3
RESPONDING TO THIS REQUEST
NON-CONFIDENTIAL DISCLOSURE
By submitting a Response you represent that the
Response does not and will not be deemed to contain
any confidential information of any kind whatsoever.
Your Response should be an executive summary (about
3 pages). The Response should briefly describe the
technical approach and provide information on
technology performance, background, and description of
the responding team and their related experience.
By submitting a Response, you acknowledge that
NineSigma’s client reserves the sole and absolute right
and discretion to select for award all, some, or none of
the Responses received for this announcement.
NineSigma’s client also may choose to select only
specific tasks within a proposal for award. NineSigma's
client has the sole and absolute discretion to determine
all award amounts.
RESPONSE EVALUATION
NineSigma’s client will evaluate the Response using the
following criteria:
 Overall scientific and technical merit of the
proposed approach
 Approach to proof of concept or performance
 Potential for proprietary position (i.e., is the
technology novel or protectable)
 Economic potential of concept
 Respondent’s capabilities and related experience
 Realism of the proposed plan and cost estimates
The client will contact respondents with highly
responsive proposals for next steps.
Offices: Cleveland - USA, Tokyo - Japan, Leuven - Belgium www.ninesigma.com